| Record |
Author  |
Cajochen, C.; Jud, C.; Munch, M.; Kobialka, S.; Wirz-Justice, A.; Albrecht, U. |
| Title |
Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans |
Type |
Journal Article |
| Year |
2006 |
Publication |
The European Journal of Neuroscience |
Abbreviated Journal |
Eur J Neurosci |
| Volume |
23 |
Issue |
4 |
Pages |
1082-1086 |
| Keywords |
Human Health; Adult; Color; Darkness; Dose-Response Relationship, Radiation; Female; Gene Expression/*radiation effects; Humans; *Light; Male; Melatonin/metabolism; Mucous Membrane/metabolism/radiation effects; Nuclear Proteins/genetics/*metabolism; Period Circadian Proteins; Transcription Factors/genetics/*metabolism |
| Abstract |
We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant in comparison to a non-light control condition only after light at 460 nm (blue) but not after light exposure at 550 nm (green). Our results indicate that the non-image-forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders. |
| Address |
Centre for Chronobiology, Psychiatric University Clinics, University of Basel, CH-4025 Basel, Switzerland. christian.cajochen@unibas.ch |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0953-816X |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16519674 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
727 |
| Permanent link to this record |
