|   | 
Details
   web
Records
Author Hsu, C.-N.; Tain, Y.-L.
Title Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease Type Journal Article
Year 2020 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci
Volume 21 Issue 6 Pages
Keywords Review; Human Health; circadian rhythm; developmental origins of health and disease (DOHaD); developmental programming; glucocorticoid; hypertension; light; melatonin; pregnancy
Abstract Light is a crucial environmental signal that affects elements of human health, including the entrainment of circadian rhythms. A suboptimal environment during pregnancy can increase the risk of offspring developing a wide range of chronic diseases in later life. Circadian rhythm disruption in pregnant women may have deleterious consequences for their progeny. In the modern world, maternal chronodisruption can be caused by shift work, jet travel across time zones, mistimed eating, and excessive artificial light exposure at night. However, the impact of maternal chronodisruption on the developmental programming of various chronic diseases remains largely unknown. In this review, we outline the impact of light, the circadian clock, and circadian signaling pathways in pregnancy and fetal development. Additionally, we show how to induce maternal chronodisruption in animal models, examine emerging research demonstrating long-term negative implications for offspring health following maternal chronodisruption, and summarize current evidence related to light and circadian signaling pathway targeted therapies in pregnancy to prevent the development of chronic diseases in offspring.
Address Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1422-0067 ISBN Medium (up)
Area Expedition Conference
Notes PMID:32210175 Approved no
Call Number GFZ @ kyba @ Serial 2874
Permanent link to this record
 

 
Author Gatford, K.L.; Kennaway, D.J.; Liu, H.; Schultz, C.G.; Wooldridge, A.L.; Kuchel, T.R.; Varcoe, T.J.
Title Simulated shift work during pregnancy does not impair progeny metabolic outcomes in sheep Type Journal Article
Year 2020 Publication The Journal of Physiology Abbreviated Journal J Physiol
Volume in press Issue Pages in press
Keywords Animals; developmental programming; maternal; metabolism; progeny; sheep; shift work
Abstract KEY POINTS: Maternal shift work increases the risk of pregnancy complications, although its effects on progeny health after birth were not clear. We evaluated the impact of a simulated shift work protocol for one third, two thirds, or all of pregnancy on metabolic health of sheep progeny. Simulated shift work had no effect on growth, body size, body composition or glucose tolerance in pre-pubertal or young adult progeny. Glucose stimulated insulin secretion was reduced in adult female progeny and insulin sensitivity was increased in adult female singleton progeny. The results of this study does not support the hypothesis that maternal shift work exposure impairs metabolic health of progeny in altricial species ABSTRACT: Disrupted maternal circadian rhythms, such as those experienced during shift work, are associated with impaired progeny metabolism in rodents. The effects of disrupted maternal circadian rhythms on progeny metabolism have not been assessed in altricial, non-litter bearing species. We therefore assessed postnatal growth from birth to adulthood, and body composition, glucose tolerance, insulin secretion and insulin sensitivity in pre-pubertal and young adult progeny of sheep exposed to control conditions (CON: 10 males, 10 females) or to a simulated shift work (SSW) protocol for the first 1/3 (SSW0-7: 11 males, 9 females), the first 2/3 (SSW0-14: 8 males, 11 females), or all (SSW0-21: 8 males, 13 females) of pregnancy. Progeny growth did not differ between maternal treatments. In pre-pubertal progeny (12-14 weeks of age), adiposity, glucose tolerance and insulin secretion during an intravenous glucose tolerance test and insulin sensitivity did not differ between maternal treatments. Similarly, in young adult progeny (12-14 months of age), food intake, adiposity and glucose tolerance did not differ between maternal treatments. At this age, however, insulin secretion in response to a glucose bolus was 30% lower in female progeny in the combined SSW groups compared to control females (P = 0.031), and insulin sensitivity of SSW0-21 singleton females was 236% that of CON singleton female progeny (P = 0.025). At least in this model, maternal SSW does not impair progeny metabolic health, with some evidence of greater insulin action in female young adult progeny. This article is protected by copyright. All rights reserved.
Address Basil Hetzel Research Institute for Translational Health Research, Adelaide, South Australia, 5011, Australia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-3751 ISBN Medium (up)
Area Expedition Conference
Notes PMID:32918750 Approved no
Call Number GFZ @ kyba @ Serial 3135
Permanent link to this record