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Author Walmsley, L.; Hanna, L.; Mouland, J.; Martial, F.; West, A.; Smedley, A.R.; Bechtold, D.A.; Webb, A.R.; Lucas, R.J.; Brown, T.M.
Title Colour As a Signal for Entraining the Mammalian Circadian Clock Type Journal Article
Year 2015 Publication PLoS Biology Abbreviated Journal PLoS Biol
Volume 13 Issue 4 Pages e1002127
Keywords Animals; biology; color; circadian disruption; animal models; mouse models; Suprachiasmatic Nucleus; Photoperiod; twilight
Abstract Twilight is characterised by changes in both quantity (“irradiance”) and quality (“colour”) of light. Animals use the variation in irradiance to adjust their internal circadian clocks, aligning their behaviour and physiology with the solar cycle. However, it is currently unknown whether changes in colour also contribute to this entrainment process. Using environmental measurements, we show here that mammalian blue-yellow colour discrimination provides a more reliable method of tracking twilight progression than simply measuring irradiance. We next use electrophysiological recordings to demonstrate that neurons in the mouse suprachiasmatic circadian clock display the cone-dependent spectral opponency required to make use of this information. Thus, our data show that some clock neurons are highly sensitive to changes in spectral composition occurring over twilight and that this input dictates their response to changes in irradiance. Finally, using mice housed under photoperiods with simulated dawn/dusk transitions, we confirm that spectral changes occurring during twilight are required for appropriate circadian alignment under natural conditions. Together, these data reveal a new sensory mechanism for telling time of day that would be available to any mammalian species capable of chromatic vision.
Address Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Corporate Author Thesis
Publisher PLOS Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1544-9173 ISBN Medium
Area Expedition Conference
Notes PMID:25884537 Approved no
Call Number IDA @ john @ Serial 1152
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Author Xiao, Q.; Gee, G.; Jones, R.R.; Jia, P.; James, P.; Hale, L.
Title Cross-sectional association between outdoor artificial light at night and sleep duration in middle-to-older aged adults: The NIH-AARP Diet and Health Study Type Journal Article
Year 2019 Publication Environmental Research Abbreviated Journal Environ Res
Volume 180 Issue Pages 108823
Keywords Remote Sensing; Human Health; Artificial light at night; Circadian disruption; Neighborhood; Sleep; Socioeconomic disadvantage
Abstract INTRODUCTION: Artificial light at night (ALAN) can disrupt circadian rhythms and cause sleep disturbances. Several previous epidemiological studies have reported an association between higher levels of outdoor ALAN and shorter sleep duration. However, it remains unclear how this association may differ by individual- and neighborhood-level socioeconomic status, and whether ALAN may also be associated with longer sleep duration. METHODS: We assessed the cross-sectional relationship between outdoor ALAN and self-reported sleep duration in 333,365 middle- to older-aged men and women in the NIH-AARP Diet and Health Study. Study participants reported baseline addresses, which were geocoded and linked with outdoor ALAN exposure measured by satellite imagery data obtained from the U.S. Defense Meteorological Satellite Program's Operational Linescan System. We used multinomial logistic regression to estimate the multinomial odds ratio (MOR) and 95% confidence intervals (CI) for the likelihood of reporting very short (<5h), short (<7h) and long (>/=9h) sleep relative to reporting 7-8h of sleep across quintiles of LAN. We also conducted subgroup analyses by individual-level education and census tract-level poverty levels. RESULTS: We found that higher levels of ALAN were associated with both very short and short sleep. When compared to the lowest quintile, the highest quintile of ALAN was associated with 16% and 25% increases in the likelihood of reporting short sleep in women (MORQ1 vs Q5, (95% CI), 1.16 (1.10, 1.22)) and men (1.25 (1.19, 1.31)), respectively. Moreover, we found that higher ALAN was associated with a decrease in the likelihood of reporting long sleep in men (0.79 (0.71, 0.89)). We also found that the associations between ALAN and short sleep were larger in neighborhoods with higher levels of poverty. CONCLUSIONS: The burden of short sleep may be higher among residents in areas with higher levels of outdoor LAN, and this association is likely stronger in poorer neighborhoods. Future studies should investigate the potential benefits of reducing light intensity in high ALAN areas in improve sleep health.
Address Program in Public Health, Department of Family, Population, and Preventive Medicine, Stony Brook Medicine, Stony Brook, NY, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0013-9351 ISBN Medium
Area Expedition Conference
Notes PMID:31627155 Approved no
Call Number GFZ @ kyba @ Serial 2702
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Author Xiao, Q.; James, P.; Breheny, P.; Jia, P.; Park, Y.; Zhang, D.; Fisher, J.A.; Ward, M.H.; Jones, R.R.
Title Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study Type Journal Article
Year 2020 Publication International Journal of Cancer Abbreviated Journal Int J Cancer
Volume in press Issue Pages
Keywords Human Health; circadian disruption; outdoor light at night; postmenopausal breast cancer; prospective cohort
Abstract Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in relation to postmenopausal breast cancer incidence over ~16 years of follow-up in 186 981 postmenopausal women including 12 318 incident postmenopausal breast cancer cases in the NIH-AARP Diet and Health Study. We used Cox proportional hazards models to estimate hazard ratios (HR) and two-sided 95% confidence intervals (CI) of the relationship between quintiles of LAN and postmenopausal breast cancer risk, overall and by hormone receptor status and cancer stage. We found that when compared to women in the lowest quintile of baseline LAN, those in the highest quintile had a 10% increase in postmenopausal breast cancer risk (HR (95% CI), 1.10 (1.02, 1.18), P-trend, .002). The association appeared to be stronger for estrogen receptor (ER) positive breast cancer (1.12 [1.02, 1.24], .007) than for ER-negative cancer (1.07 [0.85, 1.34], .66). Our findings also suggested that the relationship between LAN and breast cancer risk may differ by individual characteristics, such as smoking, alcohol drinking, sleep duration and BMI, and neighborhood environment. In conclusion, our study suggests that higher outdoor LAN exposure may be a risk factor for postmenopausal breast cancer.
Address Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0020-7136 ISBN Medium
Area Expedition Conference
Notes PMID:32488897 Approved no
Call Number GFZ @ kyba @ Serial 2976
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Author Zabiliute, A.; Vaicekauskas, R.; Vitta, P.; Zukauskas, A.
Title Phosphor-converted LEDs with low circadian action for outdoor lighting Type Journal Article
Year 2014 Publication Optics Letters Abbreviated Journal Opt Lett
Volume 39 Issue 3 Pages 563-566
Keywords LED; light emitting diode; phosphor conversion; firelight; circadian disruption
Abstract Dichromatic phosphor-converted (pc) light-emitting diodes (LEDs) with low circadian action are proposed for low-luminance photobiologically safe outdoor illumination. The LEDs feature the partial conversion of blue radiation in an orange phosphor with the resulting correlated color temperature in the “firelight” range of 1700-2500 K. The circadian action factor, which is the ratio of the biological efficacy of radiation due to the excitation of intrinsically photosensitive retinal ganglion cells to the mesopic luminous efficacy of radiation, is considerably lower than that of commercial white pc LEDs. The equivalent general color-rendering index estimated with regard to the reduced color-discrimination ability of human vision at low luminances has appropriate values in between those of common white pc LEDs and high-pressure sodium lamp.
Address Institute of Applied Research, Vilnius University, Saul&#279;tekio al. 9, bldg. III, LT-10222 Vilnius, Lithuania
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0146-9592 ISBN Medium
Area Expedition Conference
Notes PMID:24487866 Approved no
Call Number IDA @ john @ Serial 283
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