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Author Martinsons, C.; Attia, D.; Behar-Cohen, F.; Carré, S.; Enouf, O.; Falcón, J.; Gronfier, C.; Hicks, D.; Metlaine, A.; Tahkamo, L.; Torriglia, A.; Viénot, F. url  doi
openurl 
  Title Correspondence: An appraisal of the effects on human health and the environment of using light-emitting diodes Type Journal Article
  Year 2019 Publication Lighting Research & Technology Abbreviated Journal Lighting Research & Technology  
  Volume 51 Issue 8 Pages (down) 1275-1276  
  Keywords Commentary; Human Health; Ecology  
  Abstract In May 2019, a collective appraisal report of the effects on human health and the environment of systems using light emitting diodes(LEDs) was published by ANSES, the French Agency for Food, Environmental and Occupational Health and Safety. Here, the experts involved in this work provide anover view of their conclusions and recommendations.  
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  ISSN 1477-1535 ISBN Medium  
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  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2789  
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Author Lewy, A.; Wehr, T.; Goodwin, F.; Newsome, D.; Markey, S. url  doi
openurl 
  Title Light suppresses melatonin secretion in humans Type Journal Article
  Year 1980 Publication Science Abbreviated Journal Science  
  Volume 210 Issue 4475 Pages (down) 1267-1269  
  Keywords Human Health  
  Abstract Bright artificial light suppressed nocturnal secretion of melatonin in six normal human subjects. Room light of less intensity, which is sufficient to suppress melatonin secretion in other mammals, failed to do so in humans. In contrast to the results of previous experiments in which ordinary room light was used, these findings establish that the human response to light is qualitatively similar to that of other mammals.  
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  ISSN 0036-8075 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 534  
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Author Czeisler, C.; Weitzman, E.; Moore-Ede, M.; Zimmerman, J.; Knauer, R. url  doi
openurl 
  Title Human sleep: its duration and organization depend on its circadian phase Type Journal Article
  Year 1980 Publication Science Abbreviated Journal Science  
  Volume 210 Issue 4475 Pages (down) 1264-1267  
  Keywords Human Health  
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  ISSN 0036-8075 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 731  
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Author Ashkenazi, I. E.; Reinberg, A,; Bicakova-Rocher, A.; Ticher, A. url  openurl
  Title The genetic background of individual variations of circadian-rhythm periods in healthy human adults. Type Journal Article
  Year 1993 Publication American Journal of Human Genetics Abbreviated Journal  
  Volume 52 Issue 6 Pages (down) 1250–1259  
  Keywords Human Health; Adult; Body Temperature; Bronchi; Bronchi: physiology; Circadian Rhythm; Circadian Rhythm: genetics; Female; Genetic Variation; Hand; Hand: physiology; Heart Rate; Humans; Male; Middle Aged; Sex Factors; Sleep  
  Abstract As a group phenomenon, human variables exhibit a rhythm with a period (tau) equal to 24 h. However, healthy human adults may differ from one another with regard to the persistence of the 24-h periods of a set of variables' rhythms within a given individual. Such an internal desynchronization (or individual circadian dyschronism) was documented during isolation experiments without time cues, both in the present study involving 78 male shift workers and in 20 males and 19 females living in a natural setting. Circadian rhythms of sleep-wake cycles, oral temperature, grip strength of both hands, and heart rate were recorded, and power-spectra analyses of individual time series of about 15 days were used to quantify the rhythm period of each variable. The period of the sleep-wake cycle seldom differed from 24 h, while rhythm periods of the other variables exhibited a trimodal distribution (tau = 24 h, tau > 24 h, tau < 24 h). Among the temperature rhythm periods which were either < 24 h or > 24 h, none was detected between 23.2 and 24 h or between 24 and 24.8 h. Furthermore, the deviations from the 24-h period were predominantly grouped in multiples of +/- 0.8 h. Similar results were obtained when the rhythm periods of hand grip strength were analyzed (for each hand separately). In addition, the distribution of grip strength rhythm periods of the left hand exhibited a gender-related difference. These results suggested the presence of genetically controlled variability. Consequently, the distribution pattern of the periods was analyzed to elucidate its compatibility with a genetic control consisting of either a two-allele system, a multiple-allele system, or a polygenic system. The analysis resulted in structuring a model which integrates the function of a constitutive (essential) gene which produces the exact 24-h period (the Dian domain) with a set of (inducible) polygenes, the alleles of which, contribute identical time entities to the period. The time entities which affected the rhythm periods of the variables examined were in the magnitude of +/- 0.8 h. Such an assembly of genes may create periods ranging from 20 to 28 h (the Circadian domain). The model was termed by us “The Dian-Circadian Model.” This model can also be used to explain the beat phenomena in biological rhythms, the presence of 7-d and 30-d periods, and interindividual differences in sensitivity of rhythm characteristics (phase shifts, synchronization, etc.) to external (and environmental) factors.  
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  Call Number LoNNe @ schroer @ Serial 582  
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Author Savvidis, C.; Koutsilieris, M. url  doi
openurl 
  Title Circadian rhythm disruption in cancer biology Type Journal Article
  Year 2012 Publication Molecular Medicine (Cambridge, Mass.) Abbreviated Journal Mol Med  
  Volume 18 Issue Pages (down) 1249-1260  
  Keywords Human Health; Animals; CLOCK Proteins/genetics/metabolism; Circadian Clocks/genetics; *Circadian Rhythm/genetics; Environment; Humans; Melatonin/metabolism; Neoplasms/genetics/pathology/*physiopathology/therapy  
  Abstract Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological and behavioral functions of almost all species. This pattern is due to a fundamental adaptation to the rotation of Earth around its own axis. Molecular mechanisms of generation of circadian rhythms organize a biochemical network in suprachiasmatic nucleus and peripheral tissues, building cell autonomous clock pacemakers. Rhythmicity is observed in transcriptional expression of a wide range of clock-controlled genes that regulate a variety of normal cell functions, such as cell division and proliferation. Desynchrony of this rhythmicity seems to be implicated in several pathologic conditions, including tumorigenesis and progression of cancer. In 2007, the International Agency for Research on Cancer (IARC) categorized “shiftwork that involves circadian disruption [as] probably carcinogenic to humans” (Group 2A in the IARC classification system of carcinogenic potency of an agentagent) (Painting, Firefighting, and Shiftwork; IARC; 2007). This review discusses the potential relation between disruptions of normal circadian rhythms with genetic driving machinery of cancer. Elucidation of the role of clockwork disruption, such as exposure to light at night and sleep disruption, in cancer biology could be important in developing new targeted anticancer therapies, optimizing individualized chronotherapy and modifying lighting environment in workplaces or homes.  
  Address Department of Endocrinology and Metabolism, Hippocration General Hospital, Athens, Greece. csavvidis@med.uoa.gr  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1076-1551 ISBN Medium  
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  Notes PMID:22811066; PMCID:PMC3521792 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 514  
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