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Author Esaki, Y.; Obayashi, K.; Saeki, K.; Fujita, K.; Iwata, N.; Kitajima, T. url  doi
openurl 
  Title Association between light exposure at night and manic symptoms in bipolar disorder: cross-sectional analysis of the APPLE cohort Type Journal Article
  Year 2020 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume in press Issue Pages (up) in press  
  Keywords Human Health; Bipolar disorder; circadian rhythm; dark; light at night; manic symptom  
  Abstract Previous studies have found that keeping the room dark at night was associated with a decrease in manic symptoms for patients with bipolar disorder (BD). However, the association between light at night of real-life conditions and manic symptoms is unclear. We investigated the association between bedroom light exposure at night and manic symptoms in BD patients. One-hundred and eighty-four outpatients with BD participated in this cross-sectional study. The average light intensity at night during sleep was evaluated using a portable photometer for seven consecutive nights. Manic symptoms were assessed using the Young Mania Rating Scale (YMRS), and scores >/=5 were treated as a “hypomanic state.” The median (interquartile range) YMRS score was 2.0 (0-5.0), and 52 (28.2%) participants were in a hypomanic state. The prevalence of a hypomanic state was significantly higher in the participants with an average light intensity at night exposure of >/=3 lux than in those with <3 lux (36.7% versus 21.9%; P = .02). In multivariable logistic regression analysis adjusted for BD type, depressive symptoms, sleep duration, and daytime physical activity, the odds ratio (OR) for a hypomanic state was significantly higher for the participants with an average light intensity at night exposure of >/=3 lux than for those with <3 lux (OR: 2.15, 95% confidence interval: 1.09-4.22, P = .02). This association remained significant at the cutoff value of YMRS score >/=6 (OR: 2.51, 95% confidence interval: 1.15-5.46; P = .02). The findings of this study indicate bedroom light exposure at night is significantly associated with manic symptoms in BD patients. Although the results of this cross-sectional investigation do not necessarily imply causality, they may serve to inform beneficial nonpharmacological intervention and personalized treatment of BD patients.  
  Address Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan  
  Corporate Author Thesis  
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  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32238002 Approved no  
  Call Number GFZ @ kyba @ Serial 2924  
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Author Factors Influencing Quality of Sleep among Critically Ill Patients in Selected Hospitals in Western Kenya url  openurl
  Title Factors Influencing Quality of Sleep among Critically Ill Patients in Selected Hospitals in Western Kenya Type Journal Article
  Year 2018 Publication Journal of Health, Medicine and Nursing Abbreviated Journal  
  Volume 56 Issue Pages (up)  
  Keywords Human Health  
  Abstract Sleep is essential for rest, repair, well-being, and survival of the patient. Sleep quality varies in critically ill patients and is measured by patient's satisfaction of the sleep experience, integrating aspects of sleep initiation, sleep maintenance, quantity of sleep and the refreshment upon awakening. Altered sleep is a common problem experienced by patients in critical care units. This alterations may lead to physiological and psychological dysfunctions that may affect recovery. Critically ill patients frequently experience poor sleep, characterized by frequent disruptions and loss of circadian rhythms. This study investigated factors influencing the quality of sleep among critically ill patients in hospitals in Western Kenya. A cross-sectional descriptive research design was used to examine these factors. A total of 142 patients above 18 years who were admitted to the Intensive Care Unit (ICU) and those transferred from the ICU to the general ward during the study period were conveniently selected for participation in the study. For triangulation, 10 nurses who worked in the ICU also participated in the study. A structured questionnaire was used to collect data from patients while a checklist was used to observe nursing interventions. Descriptive statistical techniques used were frequencies and percentages, while chi-square was used with the p-value set at 0.05 to test the association between factors and quality of sleep. The study results showed that frequent, nursing care activities 96.5% (n=137) noise from ventilator alarms 83.1% (n=118), feeling thirsty 57.7% (n= 82) and pain 52.8% (n=75) were among the major factors influencing the quality of sleep in ICU. A one-way analysis of variance (ANOVA) revealed patient factors significantly associated with quality sleep were age p=.006 and marital status p=.02, environmental factors significantly affecting sleep were presence of light at night with a p <0.0001 and noise from alarms p=.01. Physiological factors included feeling of thirst and hunger (p=0.03). This study recommends optimal use of analgesics and sedatives for pain management, adequate fluid replacement and hydration, noise reduction strategies, including minimizing monitor and ventilator alarms, reducing staff and telephone conversations and use of ear plugs for patients in ICU. Further, nurses should implement clustered procedures to reduce disruption of sleep among critically ill patients.  
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  Notes Approved no  
  Call Number IDA @ intern @ Serial 2974  
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Author Xiao, Q.; James, P.; Breheny, P.; Jia, P.; Park, Y.; Zhang, D.; Fisher, J.A.; Ward, M.H.; Jones, R.R. url  doi
openurl 
  Title Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study Type Journal Article
  Year 2020 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume in press Issue Pages (up)  
  Keywords Human Health; circadian disruption; outdoor light at night; postmenopausal breast cancer; prospective cohort  
  Abstract Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in relation to postmenopausal breast cancer incidence over ~16 years of follow-up in 186 981 postmenopausal women including 12 318 incident postmenopausal breast cancer cases in the NIH-AARP Diet and Health Study. We used Cox proportional hazards models to estimate hazard ratios (HR) and two-sided 95% confidence intervals (CI) of the relationship between quintiles of LAN and postmenopausal breast cancer risk, overall and by hormone receptor status and cancer stage. We found that when compared to women in the lowest quintile of baseline LAN, those in the highest quintile had a 10% increase in postmenopausal breast cancer risk (HR (95% CI), 1.10 (1.02, 1.18), P-trend, .002). The association appeared to be stronger for estrogen receptor (ER) positive breast cancer (1.12 [1.02, 1.24], .007) than for ER-negative cancer (1.07 [0.85, 1.34], .66). Our findings also suggested that the relationship between LAN and breast cancer risk may differ by individual characteristics, such as smoking, alcohol drinking, sleep duration and BMI, and neighborhood environment. In conclusion, our study suggests that higher outdoor LAN exposure may be a risk factor for postmenopausal breast cancer.  
  Address Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA  
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  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32488897 Approved no  
  Call Number GFZ @ kyba @ Serial 2976  
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Author An, K.; Zhao, H.; Miao, Y.; Xu, Q.; Li, Y.-F.; Ma, Y.-Q.; Shi, Y.-M.; Shen, J.-W.; Meng, J.-J.; Yao, Y.-G.; Zhang, Z.; Chen, J.-T.; Bao, J.; Zhang, M.; Xue, T. url  doi
openurl 
  Title A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice Type Journal Article
  Year 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci  
  Volume in press Issue Pages (up)  
  Keywords Human Health  
  Abstract Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC-->dpHb-->NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.  
  Address Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. xuetian@ustc.edu.cn  
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  Series Volume Series Issue Edition  
  ISSN 1097-6256 ISBN Medium  
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  Notes PMID:32483349 Approved no  
  Call Number GFZ @ kyba @ Serial 2978  
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Author Bagci, S.; Sabir, H.; Muller, A.; Reiter, R.J. url  doi
openurl 
  Title Effects of altered photoperiod due to COVID-19 lockdown on pregnant women and their fetuses Type Journal Article
  Year 2020 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume in press Issue Pages (up) in press  
  Keywords Human Health; Covid-19; circadian disruption; fetus; lockdown; melatonin; pregnant Women  
  Abstract Maternal circadian rhythms provide highly important input into the entrainment and programming of fetal and newborn circadian rhythms. The light-dark cycle is an important regulator of the internal biological clock. Even though pregnant women spend a greater part of the day at home during the latter stages of pregnancy, natural light exposure is crucial for the fetus. The current recommended COVID-19 lockdown might dramatically alter normal environmental lighting conditions of pregnant women, resulting in exposure to extremely low levels of natural daylight and high-intensity artificial light sources during both day and night. This article summarizes the potential effects on pregnant woman and their fetuses due to prolonged exposure to altered photoperiod and as consequence altered circadian system, known as chronodisruption, that may result from the COVID-19 lockdown.  
  Address Department of Cell Systems and Anatomy, UT Health San Antonio , San Antonio, Texas, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32519912 Approved no  
  Call Number GFZ @ kyba @ Serial 3007  
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