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Author Salgado-Delgado, R.; Tapia Osorio, A.; Saderi, N.; Escobar, C. url  doi
openurl 
  Title Disruption of circadian rhythms: a crucial factor in the etiology of depression Type Journal Article
  Year 2011 Publication Depression Research and Treatment Abbreviated Journal Depress Res Treat  
  Volume 2011 Issue (up) Pages 839743  
  Keywords Human Health  
  Abstract Circadian factors might play a crucial role in the etiology of depression. It has been demonstrated that the disruption of circadian rhythms by lighting conditions and lifestyle predisposes individuals to a wide range of mood disorders, including impulsivity, mania and depression. Also, associated with depression, there is the impairment of circadian rhythmicity of behavioral, endocrine, and metabolic functions. Inspite of this close relationship between both processes, the complex relationship between the biological clock and the incidence of depressive symptoms is far from being understood. The efficiency and the timing of treatments based on chronotherapy (e.g., light treatment, sleep deprivation, and scheduled medication) indicate that the circadian system is an essential target in the therapy of depression. The aim of the present review is to analyze the biological and clinical data that link depression with the disruption of circadian rhythms, emphasizing the contribution of circadian desynchrony. Therefore, we examine the conditions that may lead to circadian disruption of physiology and behavior as described in depressive states, and, according to this approach, we discuss therapeutic strategies aimed at treating the circadian system and depression.  
  Address Departamento de Biologia Celular y Fisiologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, 04306 Mexico, DF, Mexico  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2090-1321 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21845223; PMCID:PMC3154570 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 524  
Permanent link to this record
 

 
Author Brainard, G.C.; Hanifin, J.P.; Greeson, J.M.; Byrne, B.; Glickman, G.; Gerner, E.; Rollag, M.D. url  openurl
  Title Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. Type Journal Article
  Year 2001 Publication Journal of Neuroscience Abbreviated Journal  
  Volume 21 Issue (up) Pages 6405-6412  
  Keywords Human Health  
  Abstract The photopigment in the human eye that transduces light for circadian and neuroendocrine regulation, is unknown. The aim of this study was to establish an action spectrum for light-induced melatonin suppression that could help elucidate the ocular photoreceptor system for regulating the human pineal gland. Subjects (37 females, 35 males, mean age of 24.5 ± 0.3 years) were healthy and had normal color vision. Full-field, monochromatic light exposures took place between 2:00 and 3:30 A.M. while subjects' pupils were dilated. Blood samples collected before and after light exposures were quantified for melatonin. Each subject was tested with at least seven different irradiances of one wavelength with a minimum of 1 week between each nighttime exposure. Nighttime melatonin suppression tests (n = 627) were completed with wavelengths from 420 to 600 nm. The data were fit to eight univariant, sigmoidal fluence–response curves (R 2 = 0.81–0.95). The action spectrum constructed from these data fit an opsin template (R 2 = 0.91), which identifies 446–477 nm as the most potent wavelength region providing circadian input for regulating melatonin secretion. The results suggest that, in humans, a single photopigment may be primarily responsible for melatonin suppression, and its peak absorbance appears to be distinct from that of rod and cone cell photopigments for vision. The data also suggest that this new photopigment is retinaldehyde based. These findings suggest that there is a novel opsin photopigment in the human eye that mediates circadian photoreception.  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 529  
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Author Stevens, R.G. url  openurl
  Title Electric power use and breast cancer: a hypothesis. Type Journal Article
  Year 1987 Publication Am J Epidemiol Abbreviated Journal  
  Volume 125 Issue (up) Pages 556-561  
  Keywords Human Health  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 533  
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Author Aschoff, J. url  doi
openurl 
  Title Comparative physiology: diurnal rhythms Type Journal Article
  Year 1963 Publication Annual Review of Physiology Abbreviated Journal Annu Rev Physiol  
  Volume 25 Issue (up) Pages 581-600  
  Keywords Human Health; Adaptation, Physiological; *Periodicity; *Adaptation, Physiological; *Periodicity  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0066-4278 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:13965146 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 710  
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Author Aschoff, J. url  doi
openurl 
  Title Temporal orientation: circadian clocks in animals and humans Type Journal Article
  Year 1989 Publication Animal Behaviour Abbreviated Journal Animal Behaviour  
  Volume 37 Issue (up) Pages 881-896  
  Keywords Human Health; Animals  
  Abstract  
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  Series Volume Series Issue Edition  
  ISSN 0003-3472 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 713  
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