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Author Bagci, S.; Sabir, H.; Muller, A.; Reiter, R.J. url  doi
openurl 
  Title Effects of altered photoperiod due to COVID-19 lockdown on pregnant women and their fetuses Type Journal Article
  Year 2020 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume in press Issue Pages in press  
  Keywords Human Health; Covid-19; circadian disruption; fetus; lockdown; melatonin; pregnant Women  
  Abstract Maternal circadian rhythms provide highly important input into the entrainment and programming of fetal and newborn circadian rhythms. The light-dark cycle is an important regulator of the internal biological clock. Even though pregnant women spend a greater part of the day at home during the latter stages of pregnancy, natural light exposure is crucial for the fetus. The current recommended COVID-19 lockdown might dramatically alter normal environmental lighting conditions of pregnant women, resulting in exposure to extremely low levels of natural daylight and high-intensity artificial light sources during both day and night. This article summarizes the potential effects on pregnant woman and their fetuses due to prolonged exposure to altered photoperiod and as consequence altered circadian system, known as chronodisruption, that may result from the COVID-19 lockdown.  
  Address Department of Cell Systems and Anatomy, UT Health San Antonio , San Antonio, Texas, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32519912 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 3007  
Permanent link to this record
 

 
Author Zhu, X.; Guo, X.; Zhang, J.; Liu, J.; Jiang, F. url  doi
openurl 
  Title Phosphor-free, color-mixed, and efficient illuminant: Multi-chip packaged LEDs for optimizing blue light hazard and non-visual biological effects Type Journal Article
  Year 2020 Publication Optics and Lasers in Engineering Abbreviated Journal Optics and Lasers in Engineering  
  Volume 134 Issue Pages 106174  
  Keywords Lighting; Human Health  
  Abstract Currently many evaluation models on the photobiological effects (PBE) of light sources do not consider the influence of age and luminance on the pupil diameter, which affects the light radiation intensity on the human retina. In this study, the pupil diameter is taken into consideration when evaluating the PBE of several light sources. Moreover, the correction factor M is proposed. The blue light hazard (BLH) efficacy and the circadian rhythm (CR) effects of the daylight at dusk, together with three indoor light sources with a correlated color temperature (CCT) of about 3000 K were evaluated by using a corrected evaluation model. The results show that an incandescent lamp is more photobiologically friendly for humans, despite being inefficient. Based on high wall-plug efficiency (WPE) GaN-based yellow (565 nm, 24.3%@20 A/cm2) and green (522 nm, 41.3%@20 A/cm2) LEDs on silicon substrate, incandescent-like spectrum and phosphor-free color-mixed white LEDs (CM-LEDs) with a general color rendering index (CRI) of 94, a CCT of 2866 K, and an efficiency of 131 lm/W were manufactured by mixing blue, cyan, green, yellow and red LEDs. The PBE evaluation results of such CM-LEDs are superior to those of an incandescent lamp. Moreover, blue light free and candlelight-toned LEDs with an efficiency of 120.3 lm/W, a general CRI of 84, a special CRI R9 of 93.3, and a CCT of 1810 K were fabricated by mixing yellow and red LEDs (R&Y-mixed LEDs). The R&Y-mixed LEDs show no blue light weighted quantities and have a weaker influence on the CR shift. They are photobiologically friendly for humans and suitable for nocturnal indoor and outdoor lighting environments.  
  Address  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0143-8166 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2983  
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Author An, K.; Zhao, H.; Miao, Y.; Xu, Q.; Li, Y.-F.; Ma, Y.-Q.; Shi, Y.-M.; Shen, J.-W.; Meng, J.-J.; Yao, Y.-G.; Zhang, Z.; Chen, J.-T.; Bao, J.; Zhang, M.; Xue, T. url  doi
openurl 
  Title A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice Type Journal Article
  Year 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci  
  Volume in press Issue Pages  
  Keywords Human Health  
  Abstract Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC-->dpHb-->NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.  
  Address Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. xuetian@ustc.edu.cn  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1097-6256 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32483349 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2978  
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Author Aarts, M.P.J.; Hartmeyer, S.L.; Morsink, K.; Kort, H.S.M.; de Kort, Y.A.W. url  doi
openurl 
  Title Can Special Light Glasses Reduce Sleepiness and Improve Sleep of Nightshift Workers? A Placebo-Controlled Explorative Field Study Type Journal Article
  Year 2020 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 2 Issue 2 Pages 225-245  
  Keywords Human Health  
  Abstract Nightshift workers go against the natural sleep–wake rhythm. Light can shift the circadian clock but can also induce acute alertness. This placebo-controlled exploratory field study examined the effectiveness of light glasses to improve alertness while reducing the sleep complaints of hospital nurses working nightshifts. In a crossover within-subjects design, 23 nurses participated, using treatment glasses and placebo glasses. Sleepiness and sleep parameters were measured. A linear mixed model analysis on sleepiness revealed no significant main effect of the light intervention. An interaction effect was found indicating that under the placebo condition, sleepiness was significantly higher on the first nightshift than on the last night, while under the treatment condition, sleepiness remained stable across nightshift sessions. Sleepiness during the commute home also showed a significant interaction effect, demonstrating that after the first nightshift, driver sleepiness was higher for placebo than for treatment. Subjective sleep quality showed a negative main effect of treatment vs. placebo, particularly after the first nightshift. In retrospect, both types of light glasses were self-rated as effective. The use of light glasses during the nightshift may help to reduce driver sleepiness during the commute home, which is relevant, as all participants drove home by car or (motor) bike.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2977  
Permanent link to this record
 

 
Author Xiao, Q.; James, P.; Breheny, P.; Jia, P.; Park, Y.; Zhang, D.; Fisher, J.A.; Ward, M.H.; Jones, R.R. url  doi
openurl 
  Title Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study Type Journal Article
  Year 2020 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume in press Issue Pages  
  Keywords Human Health; circadian disruption; outdoor light at night; postmenopausal breast cancer; prospective cohort  
  Abstract Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in relation to postmenopausal breast cancer incidence over ~16 years of follow-up in 186 981 postmenopausal women including 12 318 incident postmenopausal breast cancer cases in the NIH-AARP Diet and Health Study. We used Cox proportional hazards models to estimate hazard ratios (HR) and two-sided 95% confidence intervals (CI) of the relationship between quintiles of LAN and postmenopausal breast cancer risk, overall and by hormone receptor status and cancer stage. We found that when compared to women in the lowest quintile of baseline LAN, those in the highest quintile had a 10% increase in postmenopausal breast cancer risk (HR (95% CI), 1.10 (1.02, 1.18), P-trend, .002). The association appeared to be stronger for estrogen receptor (ER) positive breast cancer (1.12 [1.02, 1.24], .007) than for ER-negative cancer (1.07 [0.85, 1.34], .66). Our findings also suggested that the relationship between LAN and breast cancer risk may differ by individual characteristics, such as smoking, alcohol drinking, sleep duration and BMI, and neighborhood environment. In conclusion, our study suggests that higher outdoor LAN exposure may be a risk factor for postmenopausal breast cancer.  
  Address Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32488897 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2976  
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