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Author Bonmati-Carrion, M.; Arguelles-Prieto, R.; Martinez-Madrid, M.; Reiter, R.; Hardeland, R.; Rol, M.; Madrid, J.
Title Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure Type Journal Article
Year 2014 Publication International Journal of Molecular Sciences Abbreviated Journal IJMS
Volume 15 Issue 12 Pages 23448-23500
Keywords human health; chronodisruption; circadian; light at night (LAN); melanopsin; melatonin
Abstract Currently, in developed countries, nights are excessively illuminated (light at night), whereas daytime is mainly spent indoors, and thus people are exposed to much lower light intensities than under natural conditions. In spite of the positive impact of artificial light, we pay a price for the easy access to light during the night: disorganization of our circadian system or chronodisruption (CD), including perturbations in melatonin rhythm. Epidemiological studies show that CD is associated with an increased incidence of diabetes, obesity, heart disease, cognitive and affective impairment, premature aging and some types of cancer. Knowledge of retinal photoreceptors and the discovery of melanopsin in some ganglion cells demonstrate that light intensity, timing and spectrum must be considered to keep the biological clock properly entrained. Importantly, not all wavelengths of light are equally chronodisrupting. Blue light, which is particularly beneficial during the daytime, seems to be more disruptive at night, and induces the strongest melatonin inhibition. Nocturnal blue light exposure is currently increasing, due to the proliferation of energy-efficient lighting (LEDs) and electronic devices. Thus, the development of lighting systems that preserve the melatonin rhythm could reduce the health risks induced by chronodisruption. This review addresses the state of the art regarding the crosstalk between light and the circadian system.
Address Department of Physiology, Faculty of Biology, University of Murcia, Murcia 30100, Spain
Corporate Author Thesis
Publisher MDPI Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1422-0067 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 1078
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