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Author (down) Srinivasan, V.; Spence, D.W.; Pandi-Perumal, S.R.; Trakht, I.; Esquifino, A.I.; Cardinali, D.P.; Maestroni, G.J.
Title Melatonin, environmental light, and breast cancer Type Journal Article
Year 2008 Publication Breast Cancer Research and Treatment Abbreviated Journal Breast Cancer Res Treat
Volume 108 Issue 3 Pages 339-350
Keywords Human Health; Breast Neoplasms/*etiology/*physiopathology; Circadian Rhythm/physiology; Female; Humans; Light; Lighting/*adverse effects; Melatonin/*physiology; Occupational Exposure/adverse effects
Abstract Although many factors have been suggested as causes for breast cancer, the increased incidence of the disease seen in women working in night shifts led to the hypothesis that the suppression of melatonin by light or melatonin deficiency plays a major role in cancer development. Studies on the 7,12-dimethylbenz[a]anthracene and N-methyl-N-nitrosourea experimental models of human breast cancer indicate that melatonin is effective in reducing cancer development. In vitro studies in MCF-7 human breast cancer cell line have shown that melatonin exerts its anticarcinogenic actions through a variety of mechanisms, and that it is most effective in estrogen receptor (ER) alpha-positive breast cancer cells. Melatonin suppresses ER gene, modulates several estrogen dependent regulatory proteins and pro-oncogenes, inhibits cell proliferation, and impairs the metastatic capacity of MCF-7 human breast cancer cells. The anticarcinogenic action on MCF-7 cells has been demonstrated at the physiological concentrations of melatonin attained at night, suggesting thereby that melatonin acts like an endogenous antiestrogen. Melatonin also decreases the formation of estrogens from androgens via aromatase inhibition. Circulating melatonin levels are abnormally low in ER-positive breast cancer patients thereby supporting the melatonin hypothesis for breast cancer in shift working women. It has been postulated that enhanced endogenous melatonin secretion is responsible for the beneficial effects of meditation as a form of psychosocial intervention that helps breast cancer patients.
Address Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0167-6806 ISBN Medium
Area Expedition Conference
Notes PMID:17541739 Approved no
Call Number LoNNe @ kagoburian @ Serial 815
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Author (down) Spur, M.; Houel, N.; Tourre, V.
Title Visualizing Multilayered Geospatial Data In Virtual Reality To Assess Public Lighting Type Journal Article
Year 2020 Publication ISPRS – International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences Abbreviated Journal Int. Arch. Photogramm. Remote Sens. Spatial Inf. Sci.
Volume Xliii-B4-2020 Issue Pages 623-630
Keywords Lighting; Instrumentation; Vision
Abstract With the improvement and proliferation of virtual reality devices, their use for research and professional activity is broadening,fostering the advent of the field of immersive analytics, as is their acceptance among consumers. Other than the heightened sense of immersion into visualized data they provide, they also make displays of much larger apparent size and different positioning practical than what would be possible otherwise. Drawing on these benefits, we implemented a development of Multiple and Coordinated Displays (MCVs) for geovisualization that stacks different layers of data above each other, tilted for legibility. In a formal experiment, we evaluated it and two other, comparable MCV methods implemented in VR for their usefulness in analyzing public perception and soliciting public feedback regarding urban street lighting. In that field, the direction has recently been shifting from purely systemic development to a participatory approach, thus our investigation was into how a system like this could facilitate participation that can yield actionable results. Previous analysis of interaction data and usability questionnaires reveals preferences for certain systems depending on user characteristics, with the stack system showing a slight advantage over a grid of layers and especially over temporal multiplexing. We show that regardless of MCV variation, participants were able to analyze and provide feedback on public lighting situations that can directly contribute to urbanist work. The MCV approach further aided in understanding their choices, as eye-tracking allowed us to analyze attention to individual data layers.
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Language Summary Language Original Title
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Series Volume Series Issue Edition
ISSN 2194-9034 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 3105
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Author (down) Spoelstra, K.; van Grunsven, R.H.A.; Donners, M.; Gienapp, P.; Huigens, M.E.; Slaterus, R.; Berendse, F.; Visser, M.E.; Veenendaal, E.
Title Experimental illumination of natural habitat—an experimental set-up to assess the direct and indirect ecological consequences of artificial light of different spectral composition Type Journal Article
Year 2015 Publication Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Abbreviated Journal Philos Trans R Soc Lond B Biol Sci
Volume 370 Issue Pages 20140129
Keywords Lighting; experimental lighting; population dynamics; daily timing; seasonal timing; cascading effects; citizen science; Pipistrellus pipistrellus; bats; pipistrelle bat; wood mouse; birds
Abstract Artificial night-time illumination of natural habitats has increased dramatically over the past few decades. Generally, studies that assess the impact of artificial light on various species in the wild make use of existing illumination and are therefore correlative. Moreover, studies mostly focus on short-term consequences at the individual level, rather than long-term consequences at the population and community level—thereby ignoring possible unknown cascading effects in ecosystems. The recent change to LED lighting has opened up the exciting possibility to use light with a custom spectral composition, thereby potentially reducing the negative impact of artificial light. We describe here a large-scale, ecosystem-wide study where we experimentally illuminate forest-edge habitat with different spectral composition, replicated eight times. Monitoring of species is being performed according to rigid protocols, in part using a citizen-science-based approach, and automated where possible. Simultaneously, we specifically look at alterations in behaviour, such as changes in activity, and daily and seasonal timing. In our set-up, we have so far observed that experimental lights facilitate foraging activity of pipistrelle bats, suppress activity of wood mice and have effects on birds at the community level, which vary with spectral composition. Thus far, we have not observed effects on moth populations, but these and many other effects may surface only after a longer period of time.
Address 1 Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), PO Box 50, 6700 AB Wageningen, The Netherlands; k.spoelstra@nioo.knaw.nl
Corporate Author Thesis
Publisher Royal Society Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title The biological impacts of artificial light at night: from molecules to communities Abbreviated Series Title
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ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 1126
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Author (down) Spivey, A.
Title Light at night and breast cancer risk worldwide Type
Year 2010 Publication Environmental Health Perspectives Abbreviated Journal Environ Health Perspect
Volume 118 Issue 12 Pages a525
Keywords Human Health; Breast Neoplasms/epidemiology/*etiology/prevention & control; Female; Humans; Lighting/*adverse effects; Male; Prostatic Neoplasms/epidemiology/*etiology/prevention & control; Risk Factors
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Language English Summary Language Original Title
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Series Volume Series Issue Edition
ISSN 0091-6765 ISBN Medium
Area Expedition Conference
Notes PMID:21123149; PMCID:PMC3002207 Approved no
Call Number LoNNe @ kagoburian @ Serial 813
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Author (down) Sperber, A.N.; Elmore, A.C.; Crow, M.L.; Cawlfield, J.D.
Title Performance evaluation of energy efficient lighting associated with renewable energy applications Type Journal Article
Year 2012 Publication Renewable Energy Abbreviated Journal Renewable Energy
Volume 44 Issue Pages 423-430
Keywords Renewable energy; Energy efficiency; Ultra capacitor; Light emitting diodes; Metal halide; LED; LED lighting
Abstract Energy efficiency is a primary consideration when designing off-grid renewable energy systems including portable micro-grids. This study focuses on characterizing the potential benefits associated with using energy efficient exterior area lighting commonly associated with remote installations. Light emitting diode (LED) luminaires are becoming more commercially available, and this study compares two LED products designed for exterior lighting to traditional metal halide lamps. The characterization focuses on the use of a diesel generator, battery bank, and a bank of ultra capacitors (UCAPs) to power the lights because these systems are also used to generate or store energy at renewable energy-powered micro-grids. This field-based study quantifies the illuminance provided by each lighting system, diesel consumption rates associated with powering the lights and/or charging the batteries and UCAPs, and the time of operation for each lighting system when powered by a single discharge cycle of the batteries and UCAPs. The energy efficiency benefit of the LED luminaires is offset by their lower illuminance. However, a comparison of lighting standards for specific purposes such as security lighting indicates that LEDs may be appropriate for applications where a metal halide system would provide significantly more illumination than required at a much higher energy cost. For those purposes where higher levels of illuminance are required, the data presented in the paper may be useful in designing a renewable energy-powered micro-grid that uses multiple LED fixtures to illuminate an exterior area that is currently illuminated by a single metal halide light stand.
Address Geological Engineering, Missouri University of Science and Technology, 129 McNutt Hall, 1400 N. Bishop Avenue Rolla, MO 65409, USA
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Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0960-1481 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 335
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