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Author Fonken, L.K.; Lieberman, R.A.; Weil, Z.M.; Nelson, R.J.
Title (up) Dim light at night exaggerates weight gain and inflammation associated with a high-fat diet in male mice Type Journal Article
Year 2013 Publication Endocrinology Abbreviated Journal Endocrinology
Volume 154 Issue 10 Pages 3817-3825
Keywords Adipose Tissue, White/*immunology/metabolism/pathology; Animals; Antigens, CD11b/biosynthesis/genetics/metabolism; Appetite Regulation/*radiation effects; Arcuate Nucleus/*immunology/metabolism/pathology; Behavior, Animal/radiation effects; Circadian Rhythm; Cytokines/biosynthesis/genetics/metabolism; Diet, High-Fat/*adverse effects; Feeding Behavior/radiation effects; Gene Expression Regulation; Glucose Intolerance/etiology/immunology/metabolism/pathology; I-kappa B Kinase/biosynthesis/genetics/metabolism; Insulin Resistance; Lighting/*adverse effects; Male; Mice; Microglia/immunology/metabolism/pathology; Nerve Tissue Proteins/biosynthesis/genetics/metabolism; Obesity/*etiology/immunology/metabolism/pathology; Random Allocation; *Weight Gain
Abstract Elevated nighttime light exposure is associated with symptoms of metabolic syndrome. In industrialized societies, high-fat diet (HFD) and exposure to light at night (LAN) often cooccur and may contribute to the increasing obesity epidemic. Thus, we hypothesized that dim LAN (dLAN) would provoke additional and sustained body mass gain in mice on a HFD. Male mice were housed in either a standard light/dark cycle or dLAN and fed either chow or HFD. Exposure to dLAN and HFD increase weight gain, reduce glucose tolerance, and alter insulin secretion as compared with light/dark cycle and chow, respectively. The effects of dLAN and HFD appear additive, because mice exposed to dLAN that were fed HFD display the greatest increases in body mass. Exposure to both dLAN and HFD also change the timing of food intake and increase TNFalpha and MAC1 gene expression in white adipose tissue after 4 experimental weeks. Changes in MAC1 gene expression occur more rapidly due to HFD as compared with dLAN; after 5 days of experimental conditions, mice fed HFD already increase MAC1 gene expression in white adipose tissue. HFD also elevates microglia activation in the arcuate nucleus of the hypothalamus and hypothalamic TNFalpha, IL-6, and Ikbkb gene expression. Microglia activation is increased by dLAN, but only among chow-fed mice and dLAN does not affect inflammatory gene expression. These results suggest that dLAN exaggerates weight gain and peripheral inflammation associated with HFD.
Address Department of Neuroscience, Wexner Medical Center, The Ohio State University, 636 Biomedical Research Tower, 460 West 12th Avenue, Columbus, Ohio 43210. fonken.1@osu.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0013-7227 ISBN Medium
Area Expedition Conference
Notes PMID:23861373 Approved no
Call Number IDA @ john @ Serial 93
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Author Evans, J.A.; Elliott, J.A.; Gorman, M.R.
Title (up) Dim nighttime illumination accelerates adjustment to timezone travel in an animal model Type Journal Article
Year 2009 Publication Current Biology : CB Abbreviated Journal Curr Biol
Volume 19 Issue 4 Pages R156-7
Keywords *Adaptation, Physiological; Animals; Behavior, Animal/physiology; Biological Clocks/*physiology; Circadian Rhythm/*physiology; Cricetinae; Humans; *Lighting; Mesocricetus; Mice; Motor Activity/physiology; Phodopus; *Photoperiod; Time Factors
Abstract Jetlag reflects a mismatch between local and circadian time following rapid timezone travel [1]. Appropriately timed bright light can shift human circadian rhythms but recovery is slow (e.g., 1-2 days per timezone). Most symptoms subside after resynchronization, but chronic jetlag may have enduring negative effects [2], including even accelerated mortality in mice [3]. Melatonin, prescription drugs, and/or exercise may help shift the clock but, like bright light, require complex schedules of application [1]. Thus, there is a need for more efficient and practical treatments for addressing jetlag. In contrast to bright daytime lighting, nighttime conditions have received scant attention. By incorporating more naturalistic nighttime lighting comparable in intensity to dim moonlight, we demonstrate that recovery after simulated jetlag is accelerated when nights are dimly lit rather than completely dark.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0960-9822 ISBN Medium
Area Expedition Conference
Notes PMID:19243688 Approved no
Call Number IDA @ john @ Serial 152
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Author Evans, J.A.; Carter, S.N.; Freeman, D.A.; Gorman, M.R.
Title (up) Dim nighttime illumination alters photoperiodic responses of hamsters through the intergeniculate leaflet and other photic pathways Type Journal Article
Year 2012 Publication Neuroscience Abbreviated Journal Neuroscience
Volume 202 Issue Pages 300-308
Keywords Animals; Biological Clocks/physiology; Circadian Rhythm/physiology; Cricetinae; Darkness; Data Interpretation, Statistical; Geniculate Bodies/*physiology; *Lighting; Male; Motor Activity/physiology; Phodopus; *Photoperiod; Visual Pathways/*physiology
Abstract In mammals, light entrains the central pacemaker within the suprachiasmatic nucleus (SCN) through both a direct neuronal projection from the retina and an indirect projection from the intergeniculate leaflet (IGL) of the thalamus. Although light comparable in intensity to moonlight is minimally effective at resetting the phase of the circadian clock, dimly lit and completely dark nights are nevertheless perceived differentially by the circadian system, even when nighttime illumination is below putative thresholds for phase resetting. Under a variety of experimental paradigms, dim nighttime illumination exerts effects that may be characterized as enhancing the plasticity of circadian entrainment. For example, relative to completely dark nights, dimly lit nights accelerate development of photoperiodic responses of Siberian hamsters transferred from summer to winter day lengths. Here we assess the neural pathways underlying this response by testing whether IGL lesions eliminate the effects of dim nighttime illumination under short day lengths. Consistent with previous work, dimly lit nights facilitated the expansion of activity duration under short day lengths. Ablation of the IGL, moreover, did not influence photoperiodic responses in animals held under completely dark nights. However, among animals that were provided dimly lit nights, IGL lesions prevented the short-day typical expansion of activity duration as well as the seasonally appropriate gonadal regression and reduction in body weight. Thus, the present data indicate that the IGL plays a central role in mediating the facilitative effects of dim nighttime illumination under short day lengths, but in the absence of the IGL, dim light at night influences photoperiodic responses through residual photic pathways.
Address Department of Psychology, University of California, San Diego, La Jolla, CA, USA. jevans@msm.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0306-4522 ISBN Medium
Area Expedition Conference
Notes PMID:22155265; PMCID:PMC3578228 Approved no
Call Number IDA @ john @ Serial 87
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Author Bailey, F.; Sparks, C.P.; Seabrook, A.H.; Vignoles, W.A.; Trotter, A.P.; Gaster, L.; Cooper, W.R.; Shaw, C.M.; Morris, J.T.; Russell, C.N.; Edgcumbe, K.; Boot, H.L.P.; Dow, J.S.; Fedden, S.E.; Mackenzie, J.D.; Sexton, F.P.; Wilkinson, H.D.; Scott, E.K.; Hollis, E.P.; Pearce, S.L.; Frith, J.; Angus, H.W.; Cooper, A.G.; Moon, O.; Sells, F.; Crews, H.C.; Solomon, M.; Chattock, R.A.; Sumpner, W.E.; Augold, A.E.; Morcom, R.K.; Harrison, H.T.
Title (up) Discussion on: “Street lighting by modern electric lamps” Type Journal Article
Year 1911 Publication Journal of the Institution of Electrical Engineers Abbreviated Journal
Volume 46 Issue 205 Pages 46-91
Keywords Lighting; Commentary
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2054-0612 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2740
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Author Marchant, P.
Title (up) Do brighter, whiter street lights improve road safety? Type Journal Article
Year 2019 Publication Significance Abbreviated Journal Significance
Volume 16 Issue 5 Pages 8-9
Keywords Public Safety; Lighting; Statistics
Abstract Would a billion‐dollar investment in improved street lighting make Australian roads safer at night? Paul Marchant finds the evidence wanting
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1740-9705 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2686
Permanent link to this record