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Author Garaulet, M.; Ordovas, J.M.; Madrid, J.A. url  doi
openurl 
  Title The chronobiology, etiology and pathophysiology of obesity Type Journal Article
  Year 2010 Publication International Journal of Obesity (2005) Abbreviated Journal Int J Obes (Lond)  
  Volume 34 Issue 12 Pages 1667-1683  
  Keywords Human Health; Animals; CLOCK Proteins/genetics/*physiology; Circadian Rhythm/genetics/*physiology; Energy Intake/*physiology; Feeding Behavior/physiology; Humans; Mice; Motor Activity/physiology; *Obesity/etiology/physiopathology; Sleep/physiology; Sleep Deprivation/complications/genetics/*physiopathology  
  Abstract The effect of CD on human health is an emerging issue. Many records link CD with diseases such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to premature aging. The amount of sleep has declined by 1.5 h over the past century, accompanied by an important increase in obesity. Shift work, sleep deprivation and exposure to bright light at night increase the prevalence of adiposity. Animal models have shown that mice with Clock gene disruption are prone to developing obesity and MetS. This review summarizes the latest developments with regard to chronobiology and obesity, considering (1) how molecular clocks coordinate metabolism and the specific role of the adipocyte; (2) CD and its causes and pathological consequences; (3) the epidemiological evidence of obesity as a chronobiological illness; and (4) theories of circadian disruption and obesity. Energy intake and expenditure, relevance of sleep, fat intake from a circadian perspective and psychological and genetic aspects of obesity are examined. Finally, ideas about the use of chronobiology in the treatment of obesity are discussed. Such knowledge has the potential to become a valuable tool in the understanding of the relationship between the chronobiology, etiology and pathophysiology of obesity.  
  Address Faculty of Biology, Department of Physiology, Campus of Espinardo, University of Murcia, Murcia, Spain. garaulet@um.es  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0307-0565 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20567242 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 755  
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Author Cornean, R.E.; Margescu, M.; Simionescu, B. url  openurl
  Title Disruption of the Cyrcadian System and Obesity Type Journal Article
  Year 2015 Publication Jurnalul Pediatrului Abbreviated Journal Jurnalul Pediatrului  
  Volume XVIII Issue Supplement 3 Pages 38-42  
  Keywords Human Health; sleep deprivation; circadian rhythms; *Chronobiology Disorders; chronodisruption; obesity  
  Abstract Disruption of the cyrcadian system is a relatively new concept incriminated as being responsible for obesity, cardiovascular involvement, cognitive impairment, premature aging and last but not least, cancer. Because obesity is undoubtedly assimilated today to the medical conditions related to the disruption of the normal chronobiology, this paper presents the pivotal role of chronodisruption in the neuroendocrine control of appetite among these patients.  
  Address University of Medicine and Pharmacy "Iuliu Hatieganu” Cluj – Napoca, Romania; recornean(as)yahoo.com  
  Corporate Author Thesis  
  Publisher Romanian Society of Pediatric Surgery Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2065-4855 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 1349  
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