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Author Alves-Simoes, M.; Coleman, G.; Canal, M.
Title Effects of type of light on mouse circadian behaviour and stress levels Type Journal Article
Year (down) 2015 Publication Laboratory Animals Abbreviated Journal Lab. Anim.
Volume 50 Issue 1 Pages 21-29
Keywords Animals; mouse; albino; pigmented; fluorescent light; LED light; Circadian Rhythm
Abstract Light is the principal synchronizing environmental factor for the biological clock. Light quantity (intensity), and light quality (type of light source) can have different effects. The aim of this study was to determine the effects of the type of light experienced from the time of birth on mouse growth, circadian behaviour and stress levels. We raised pigmented and albino mice under 24 h light–dark cycles of either fluorescent or white light-emitting diode (LED) light source during the suckling stage, and the animals were then exposed to various light environments after weaning and their growth rate, locomotor activity and plasma corticosterone concentration were measured. We found that the type of light the animals were exposed to did not affect the animals’ growth rates or stress levels. However, we observed significant effects on the expression of the locomotor activity rhythm under low contrast light–dark cycles in pigmented mice, and under constant light in both albino and pigmented mice. These results highlight the importance of environmental light quality (light source) on circadian behavioural rhythms, and the need for close monitoring of light environments in animal facilities.
Address University of Manchester, Faculty of Life Sciences, AV Hill Building, Oxford Road, Manchester M13 9PT, UK. Email: maria.canal{at}manchester.ac.uk
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Language English Summary Language English Original Title
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Call Number IDA @ john @ Serial 1177
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