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Author Russart, K.L.G.; Chbeir, S.A.; Nelson, R.J.; Magalang, U.J.
Title Light at night exacerbates metabolic dysfunction in a polygenic mouse model of type 2 diabetes mellitus Type Journal Article
Year 2019 Publication Life Sciences Abbreviated Journal Life Sci
Volume 231 Issue Pages 116574
Keywords Animals; diabetes; human health; mouse models; Type 2 diabetes; Insulin Resistance
Abstract (up) AIMS: Electric lighting is beneficial to modern society; however, it is becoming apparent that light at night (LAN) is not without biological consequences. Several studies have reported negative effects of LAN on health and behavior in humans and nonhuman animals. Exposure of non-diabetic mice to dim LAN impairs glucose tolerance, whereas a return to dark nights (LD) reverses this impairment. We predicted that exposure to LAN would exacerbate the metabolic abnormalities in TALLYHO/JngJ (TH) mice, a polygenic model of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We exposed 7-week old male TH mice to either LD or LAN for 8-10weeks in two separate experiments. After 8weeks of light treatment, we conducted intraperitoneal glucose tolerance testing (ipGTT) followed by intraperitoneal insulin tolerance testing (ipITT). In Experiment 1, all mice were returned to LD for 4weeks, and ipITT was repeated. KEY FINDINGS: The major results of this study are i) LAN exposure for 8weeks exacerbates glucose intolerance and insulin resistance ii) the effects of LAN on insulin resistance are reversed upon return to LD, iii) LAN exposure results in a greater increase in body weight compared to LD exposure, iv) LAN increases the incidence of mice developing overt T2DM, and v) LAN exposure decreases survival of mice with T2DM. SIGNIFICANCE: In conclusion, LAN exacerbated metabolic abnormalities in a polygenic mouse model of T2DM, and these effects were reversed upon return to dark nights. The applicability of these findings to humans with T2DM needs to be determined.
Address Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0024-3205 ISBN Medium
Area Expedition Conference
Notes PMID:31207311 Approved no
Call Number GFZ @ kyba @ Serial 2549
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Author Padilla-Martinez, J.M.; Abad-Corpa, E.; Gea-Sanchez, M.; Casado-Ramirez, E.; Rol-de Lama, M.A.; Madrid-Perez, J.A.; Moreno-Casbas, M.T.
Title “Detection of factors influencing circadian rhythms on Intensive Care inpatients and hospitalization: Protocol for an observational study” Type Journal Article
Year 2020 Publication Journal of Advanced Nursing Abbreviated Journal J Adv Nurs
Volume in press Issue Pages in press
Keywords Human Health; care; circadian rhythm; hospitalization; light; noise; nursing; nursing activities; protocol; sleep quality
Abstract (up) AIMS: Identify the prevalence of circadian health disorders in ICU and hospitalized patients. Stablish the relationship of the circadian system with light, temperature, noise and nursing activities. BACKGROUND: Commonly, self-assessment through subjective questionnaires is used for research about sleep quality. However, more reliable and valid measures should be applied objectively to find out the real prevalence of the problem. There is a negative relationship between circadian rhythms and hospitalization. In this study, we will analyse sleep patterns and hospital environments to implement measures to improve the quality of care related to sleep. DESIGN: Descriptive observational study. It is estimated that 975 patients from 13 hospitals need to be recruited from ICU and hospitalization units. The sample should meet the following criteria: Patients over 18 admitted to ICU and medical units, length of stay between 96-148 hr, with no visual, hearing or moderate-severe cognitive impairment. Variables: Sleep variables are collected with an electronic device (named Kronowise(R) and Kronobed(R)), circadian and infrared light exposure, environmental noise, temperature, unit structural characteristics, nursing care (from 0 to 6 a.m.) and, characteristics of hospitalization period. The study, registered on Clinical Trials, initiated in December 2019 and it will continue up to December 2022. DISCUSSION: Using objective and subjective measures of sleep and circadian rhythms, this study will shed light on the factors that negatively affect the hospitalized patients' sleep quality and circadian health. The ultimate goal is to design hospital guidelines to minimize the adverse effects on the dependent variables studied. Arguably, these guidelines will contribute to reducing the risk of these alterations and it will also serve to improve the nursing activities. CONCLUSION: We expect to obtain adequate results for the creation of a protocol to improve the circadian health, quality of care and health outcomes related to sleep in patients.
Address Biomedical Research Center for Fragility and Healthy Aging (CIBERFES), Madrid, Spain
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0309-2402 ISBN Medium
Area Expedition Conference
Notes PMID:32996642 Approved no
Call Number GFZ @ kyba @ Serial 3165
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Author Stern, M.; Broja, M.; Sansone, R.; Grone, M.; Skene, S.S.; Liebmann, J.; Suschek, C.V.; Born, M.; Kelm, M.; Heiss, C.
Title Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans Type Journal Article
Year 2018 Publication European Journal of Preventive Cardiology Abbreviated Journal Eur J Prev Cardiol
Volume 25 Issue 17 Pages 1875-1883
Keywords Human Health; Blue light; blood pressure; endothelial function; forearm blood flow; pulse wave velocity
Abstract (up) AIMS: Previous studies have shown that ultraviolet light can lead to the release of nitric oxide from the skin and decrease blood pressure. In contrast to visible light the local application of ultraviolet light bears a cancerogenic risk. Here, we investigated whether whole body exposure to visible blue light can also decrease blood pressure and increase endothelial function in healthy subjects. METHODS: In a randomised crossover study, 14 healthy male subjects were exposed on 2 days to monochromatic blue light or blue light with a filter foil (control light) over 30 minutes. We measured blood pressure (primary endpoint), heart rate, forearm vascular resistance, forearm blood flow, endothelial function (flow-mediated dilation), pulse wave velocity and plasma nitric oxide species, nitrite and nitroso compounds (secondary endpoints) during and up to 2 hours after exposure. RESULTS: Blue light exposure significantly decreased systolic blood pressure and increased heart rate as compared to control. In parallel, blue light significantly increased forearm blood flow, flow-mediated dilation, circulating nitric oxide species and nitroso compounds while it decreased forearm vascular resistance and pulse wave velocity. CONCLUSION: Whole body irradiation with visible blue light at real world doses improves blood pressure, endothelial function and arterial stiffness by nitric oxide released from photolabile intracutanous nitric oxide metabolites into circulating blood.
Address Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford GU2 7XH, UK. Email: c.heiss(at)
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2047-4873 ISBN Medium
Area Expedition Conference
Notes PMID:30196723 Approved no
Call Number IDA @ john @ Serial 2157
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Author Alamús, R.; Bará, S.; Corbera, J.; Escofet, J.; Palà , V.; Pipia, L.; Tardà, A.
Title Ground-based hyperspectral analysis of the urban nightscape Type Journal Article
Year 2017 Publication ISPRS Journal of Photogrammetry and Remote Sensing Abbreviated Journal ISPRS Journal of Photogrammetry and Remote Sensing
Volume 124 Issue Pages 16-26
Keywords Instrumentation; Remote Sensing
Abstract (up) Airborne hyperspectral cameras provide the basic information to estimate the energy wasted skywards by outdoor lighting systems, as well as to locate and identify their sources. However, a complete characterization of the urban light pollution levels also requires evaluating these effects from the city dwellers standpoint, e.g. the energy waste associated to the excessive illuminance on walls and pavements, light trespass, or the luminance distributions causing potential glare, to mention but a few. On the other hand, the spectral irradiance at the entrance of the human eye is the primary input to evaluate the possible health effects associated with the exposure to artificial light at night, according to the more recent models available in the literature. In this work we demonstrate the possibility of using a hyperspectral imager (routinely used in airborne campaigns) to measure the ground-level spectral radiance of the urban nightscape and to retrieve several magnitudes of interest for light pollution studies. We also present the preliminary results from a field campaign carried out in the downtown of Barcelona.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0924-2716 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1613
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Author Peregrym, M.; Penzesne Konya, E.; Falchi, F.
Title Very important dark sky areas in Europe and the Caucasus region Type Journal Article
Year 2020 Publication Journal of Environmental Management Abbreviated Journal J Environ Manage
Volume 274 Issue Pages 111167
Keywords Conservation; Skyglow; Alan; Caucasus; Europe; Light pollution; Protected areas; Very important dark area
Abstract (up) ALAN (artificial light at night) can give, if done adequately, a lot of benefits for human society, but it affects reproduction, navigation, foraging, habitat selection, communication, trophic and social interactions of the biota in the same time. Taking into account dramatic increase in light pollution of the night sky and night environment during the past decades, the creation of refugia where natural habitats are not influenced by ALAN is very important. We selected promising territories without, or with a low impact of, ALAN for the development of a VIDA (Very Important Dark Area) Network in Europe and the Caucasus region. 54 VIDAs within the borders of 30 countries were chosen, located in different biogeographic regions, at different altitudes, and in juxtaposition with protected areas. Special attention has been paid to sea and ocean islands, non-polluted by ALAN, as well as to large parts of European Russia and Kazakhstan where there is still a low level of light pollution. These places might be a basis for the protection of biodiversity from the consequences of ALAN, and they can also serve as key education centers for increasing the awareness of the problem of light pollution of the sky at night. Due to the fact that light propagates far away in the atmosphere, the protection of VIDAs can be obtained only if a strong anti-light pollution action is enforced also in the surrounding areas, at least 100 km from the borders of the VIDAs.
Address Istituto di Scienza e Tecnologia dell'Inquinamento Luminoso (Light Pollution Science and Technology Institute), 36016, Thiene, Italy; Departamento de Fisica Aplicada, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Galicia, Spain
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0301-4797 ISBN Medium
Area Expedition Conference
Notes PMID:32791325 Approved no
Call Number GFZ @ kyba @ Serial 3074
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