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Author (down) Xiang, S.; Dauchy, R.T.; Hoffman, A.E.; Pointer, D.; Frasch, T.; Blask, D.E.; Hill, S.M. url  doi
openurl 
  Title Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer Type Journal Article
  Year 2019 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res  
  Volume 67 Issue 2 Pages e12586  
  Keywords Animals; Human Health; Circadian Rhythm; Cancer; tumor suppression  
  Abstract Disruption of circadian time structure and suppression of circadian nocturnal melatonin (MLT) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep-wake cycles, is associated with a significantly increased risk of breast cancer and resistance to tamoxifen and doxorubicin. Melatonin inhibition of human breast cancer chemo-resistance involves mechanisms including suppression of tumor metabolism and inhibition of kinases and transcription factors which are often activated in drug-resistant breast cancer. Signal Transducer and Activator of Transcription 3 (STAT3), frequently overexpressed and activated in Paclitaxel (PTX)-resistant breast cancer, promotes the expression of DNA methyltransferase one (DNMT1) to epigenetically suppresses the transcription of tumor suppressor Aplasia Ras homolog one (ARHI) which can sequester STAT3 in the cytoplasm to block PTX-resistance. We demonstrate that breast tumor xenografts in rats exposed to dLAN and circadian MLT disrupted express elevated levels of phosphorylated and acetylated STAT3, increased DNMT1, but reduced Sirtuin 1 (SIRT1) and ARHI. Furthermore, MLT and/or SIRT1 administration blocked/reversed Interleukin 6 (IL-6)-induced acetylation of STAT3 and its methylation of ARH1 to increase ARH1 mRNA expression in MCF-7 breast cancer cells. Finally, analyses of the I-SPY 1 trial demonstrates that elevated MT1 receptor expression is significantly correlated with pathologic complete response following neo-adjuvant therapy in breast cancer patients. This is the first study to demonstrate circadian disruption of MLT by dLAN driving intrinsic resistance to PTX via epigenetic mechanisms increasing STAT3 expression and that MLT administration can reestablish sensitivity of breast tumors to PTX and drive tumor regression.  
  Address Tulane Circadian Cancer Biology Group, New Orleans, Louisiana  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-3098 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31077613 Approved no  
  Call Number GFZ @ kyba @ Serial 2383  
Permanent link to this record
 

 
Author (down) Xia, C.; Yeh, A.G.-O.; Zhang, A. url  doi
openurl 
  Title Analyzing spatial relationships between urban land use intensity and urban vitality at street block level: A case study of five Chinese megacities Type Journal Article
  Year 2020 Publication Landscape and Urban Planning Abbreviated Journal Landscape and Urban Planning  
  Volume 193 Issue Pages 103669  
  Keywords Remote Sensing  
  Abstract Urban sprawl in urbanizing China has resulted in a series of ecological and environmental problems. Urban planners have been committed to promoting compact development through high-density and mixed land use. However, a problem brought by such compact urban form is the mismatch between physical spaces and socio-economic activities. To date, minimal research has been conducted using spatial statistics to study this issue at the local scales. Moreover, urban night-time vitality has been consistently ignored in existing studies. In the current work, urban land use intensity was analyzed on the basis of street block density and typology, and urban daytime and night-time vitality were measured using small catering business and night-time light data, respectively. The spatial relationships between urban land use intensity and urban vitality were investigated using a local indicator of spatial association (LISA), and five megacities in China were taken as a case study to examine whether variations exist between different cities. Results showed a significant positive spatial autocorrelation between urban land use intensity and urban vitality according to global statistics. Therefore, socio-economic activities are more likely to be abundant in densely developed urban areas. However, local spatial mismatches were found in the five megacities, indicating overcrowded or underutilized urban spaces in all the cities. These relationships were associated with different urban areas (urbanized before 1995 and during 1995–2015), land use conditions (function and mixture) and time periods (day and night). The results of this work will provide a comprehensive understanding of compact city and sustainability.  
  Address  
  Corporate Author Thesis  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0169-2046 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2697  
Permanent link to this record
 

 
Author (down) Xavier Kerola, D. url  doi
openurl 
  Title Modelling artificial night-sky brightness with a polarized multiple scattering radiative transfer computer code: Modelling artificial night-sky brightness Type Journal Article
  Year 2006 Publication Monthly Notices of the Royal Astronomical Society Abbreviated Journal  
  Volume 365 Issue 4 Pages 1295-1299  
  Keywords Skyglow; modeling; radiative transfer; Gauss-Seidel; light pollution; Garstang model  
  Abstract As part of an ongoing investigation of radiative effects produced by hazy atmospheres, computational procedures have been developed for use in determining the brightening of the night sky as a result of urban illumination. The downwardly and upwardly directed radiances of multiply scattered light from an offending metropolitan source are computed by a straightforward Gauss-Seidel (G-S) iterative technique applied directly to the integrated form of Chandrasekhar's vectorized radiative transfer equation. Initial benchmark night-sky brightness tests of the present G-S model using fully consistent optical emission and extinction input parameters yield very encouraging results when compared with the double scattering treatment of Garstang, the only full-fledged previously available model.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0035-8711 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 278  
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Author (down) Wurtman, R.J. url  doi
openurl 
  Title The Pineal and Endocrine Function Type Journal Article
  Year 1969 Publication Hospital Practice Abbreviated Journal Hospital Practice  
  Volume 4 Issue 1 Pages 32-37  
  Keywords Human Health  
  Abstract Recognition that levels of hormonal secretion vary markedly from day to night has triggered intensive investigation into the influence of environmental light upon endocrine function. These studies have pointed to the pineal gland as a major mediator of a wide variety of hormonal responses involving the gonads, thyroid, and pituitary, and the hypothalamus and other regions of the brain.  
  Address Human Health  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2154-8331 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2037  
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Author (down) Wuchterl, G.; Reithofer, M. url  openurl
  Title Licht über Wien V Type Journal Article
  Year 2017 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords Skyglow  
  Abstract Die hier präsentierte Studie gibt einen detaillierten Überblick zur Entwicklung derLichtverschmutzung über dem Stadtgebiet von Wien in den Jahren 2011 bis 2017 und bietet einePrognose bis 2020. Damit ist international erstmals eine Langzeitstudie über die Entwicklung derLichtverschmutzung einer Großstadt verfügbar. Im Rahmen der begleitenden Untersuchungen sindAussagen über die Verursacher und ihre spezifischen Anteile an der Lichtverschmutzung Wiensmöglich. Die aktuelle Umrüstung auf LED-Technik wird diskutiert und findet Eingang in diePrognose. Neue Messungen und Analysen von internationalen Teams werden kurz vorgestellt undbezüglich ihrer Relevanz vergleichend mit unserer Studie diskutiert.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language German Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2717  
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