toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author (up) Anbalagan, M.; Dauchy, R.; Xiang, S.; Robling, A.; Blask, D.; Rowan, B.; Hill, S. url  doi
openurl 
  Title SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases Type Journal Article
  Year 2019 Publication Journal of the Endocrine Society Abbreviated Journal  
  Volume 3 Issue Supplement_1 Pages  
  Keywords Human Health; Cancer; Breast cancer; melatonin; shift work; mouse models  
  Abstract Breast cancer metastasis to bone is a major source of morbidity and mortality in women with advanced metastatic breast cancer. Morbidity from metastasis to bone is compounded by the fact that they cannot be surgically removed and can only be treated with chemotherapy and/or radiation therapy. Thus, there is critical need to develop new treatment strategies that kill bone metastatic tumors and reduce osteolytic lesions to improve patient quality of life and extend patient survival. Circadian rhythms are daily cycles of ~24 h that control many if not most physiologic processes and their disruption by exposure to light at night (LAN) or jet lag has been shown to be strongly associated with the development of cancer, particularly breast cancer. We have found that disruption of the anti-cancer circadian hormone melatonin (MLT) by light at night can significantly enhance the metastatic potential in breast cancer cells. Our work supports the report of the International Agency for Research on Cancer that shift work is a “probable human carcinogen” and highlights the association between exposure to light at night and invasive breast cancer. We recently reported that human breast tumor xenografts grown in athymic nude female rats housed in a photoperiod of 12h light at day: 12h dim light at night (dLAN, 0.2 lux – blocks the nighttime circadian MLT signal), display resistance to doxorubicin (Dox). More importantly, tumor growth and drug resistance could be blocked by the administration of Dox in circadian alignment with nocturnal MLT during dLAN. Our recent preliminary studies show that poorly invasive ERα positive MCF-7 breast cancer cells, when injected into the tibia (to mimic bone metastatic disease) of Foxn1nu athymic nude mice (which produce a strong circadian nighttime melatonin signal) housed in a dLAN photoperiod (suppressed nocturnal MLT production) developed full blown breast cancer tumors in bone (P<0.05) that are highly osteolytic (P<0.05). Moreover, patients with metastatic breast cancer are routinely treated with doxorubicin, which itself can promote bone damage. Our studies demonstrate that MLT slows the growth of metastatic breast cancer in bone but that the chrono-therapeutic use of doxorubicin in circadian alignment with melatonin in Foxn1nu mice with tibial breast tumors, reduced tumor growth in bone, reduced bone erosion, and promoted the formation of new bone. Successful use of this chronotherapeutic use of Dox and MLT in clinical trials increasing efficacy in preventing or suppressing breast cancer metastasis to bone while decreasing toxic side effects of doxorubicin would provide a revolutionary advancement in the treatment of bone metastatic breast cancer and decrease the morbidity and mortality associated with breast cancer metastasis to bone.  
  Address Tulane University School of Medicine, New Orleans, LA, United States  
  Corporate Author Thesis  
  Publisher Oxford Academic Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2472-1972 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2433  
Permanent link to this record
 

 
Author (up) Andrade-Núñez, M.J.; Aide, T.M. url  doi
openurl 
  Title The Socio-Economic and Environmental Variables Associated with Hotspots of Infrastructure Expansion in South America Type Journal Article
  Year 2020 Publication Remote Sensing Abbreviated Journal Remote Sensing  
  Volume 12 Issue 1 Pages 116  
  Keywords Remote Sensing  
  Abstract The built environment, defined as all human-made infrastructure, is increasing to fulfill the demand for human settlements, productive systems, mining, and industries. Due to the profound direct and indirect impacts that the built environment produces on natural ecosystems, it is considered a major driver of land change and biodiversity loss, and a major component of global environmental change. In South America, a global producer of minerals and agricultural commodities, and a region with many biodiversity hotspots, infrastructure expanded considerably between 2001 and 2011. This expansion occurred mainly in rural areas, towns, and sprawling suburban areas that were not previously developed. Herein, we characterized the areas of major infrastructure expansion between 2001 and 2011 in South America. We used nighttime light data, land use maps, and socio-economic and environmental variables to answer the following questions: (1) Where are the hotspots of infrastructure expansion located? and (2) What combination of socio-economic and environmental variables are associated with infrastructure expansion? Hotspots of infrastructure expansion encompass 70% (337,310 km2) of the total infrastructure expansion occurring between 2001 and 2011 across South America. Urban population and economic growth, mean elevation, and mean road density were the main variables associated with the hotspots, grouping them into eight clusters. Furthermore, within the hotspots, woody vegetation increased around various urban centers, and several areas showed a large increase in agriculture. Investments in large scale infrastructure projects, and the expansion and intensification of productive systems (e.g., agriculture and meat production) play a dominant role in the increase of infrastructure across South America. We expect that under the current trends of globalization and land changes, infrastructure will continue increasing and expanding into no-development areas and remote places. Therefore, to fully understand the direct and indirect impacts of land use change in natural ecosystems studies of infrastructure need to expand to areas beyond cities. This will provide better land management alternatives for the conservation of biodiversity as well as peri-urban areas across South America.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2072-4292 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2798  
Permanent link to this record
 

 
Author (up) Andrade-Pacheco, R.; Savory, D.J.; Midekisa, A.; Gething, P.W.; Sturrock, H.J.W.; Bennett, A. url  doi
openurl 
  Title Household electricity access in Africa (2000-2013): Closing information gaps with model-based geostatistics Type Journal Article
  Year 2019 Publication PloS one Abbreviated Journal PLoS One  
  Volume 14 Issue 5 Pages e0214635  
  Keywords Remote Sensing  
  Abstract Household electricity access data in Africa are scarce, particularly at the subnational level. We followed a model-based Geostatistics approach to produce maps of electricity access between 2000 and 2013 at a 5 km resolution. We collated data from 69 nationally representative household surveys conducted in Africa and incorporated nighttime lights imagery as well as land use and land cover data to produce maps of electricity access between 2000 and 2013. The information produced here can be an aid for understanding of how electricity access has changed in the region during this 14 year period. The resolution and the continental scale makes it possible to combine these data with other sources in applications in the socio-economic field, both at a local or regional level.  
  Address Malaria Elimination Initiative, Institute for Global Health Sciences, UCSF, San Francisco, CA, United States of America  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31042727; PMCID:PMC6493706 Approved no  
  Call Number GFZ @ kyba @ Serial 2531  
Permanent link to this record
 

 
Author (up) Andreatta, G.; Tessmar-Raible, K. url  doi
openurl 
  Title The still dark side of the moon: molecular mechanisms of lunar-controlled rhythms and clocks Type Journal Article
  Year 2020 Publication Journal of Molecular Biology Abbreviated Journal J Mol Biol  
  Volume in press Issue Pages  
  Keywords Review; Animals; Hormones; Lunar rhythms; Physiology; Proteome; Transcriptome  
  Abstract Starting with the beginning of the last century, a multitude of scientific studies has documented that the lunar cycle times behaviors and physiology in many organisms. It is plausible that even the first life forms adapted to the different rhythms controlled by the moon. Consistently, many marine species exhibit lunar rhythms, and also the number of documented “lunar-rhythmic” terrestrial species is increasing. Organisms follow diverse lunar geophysical/astronomical rhythms, which differ significantly in terms of period length: from hours (circalunidian and circatidal rhythms) to days (circasemilunar and circalunar cycles). Evidence for internal circatital and circalunar oscillators exists for a range of species based on past behavioral studies, but those species with well-documented behaviorally free-running lunar rhythms are not typically used for molecular studies. Thus, the underlying molecular mechanisms are largely obscure: the dark side of the moon. Here we review findings which start to connect molecular pathways with moon-controlled physiology and behaviors. The present data indicate connections between metabolic/endocrine pathways and moon-controlled rhythms, as well as interactions between circadian and circatidal/circalunar rhythms. Moreover, recent high-throughput analyses provide useful leads towards pathways, as well as molecular markers. However, for each interpretation it is important to carefully consider the – partly substantially differing – conditions used in each experimental paradigm. In the future, it will be important to use lab experiments to delineate the specific mechanisms of the different solar- and lunar-controlled rhythms, but to also start integrating them together, as life has evolved equally long under rhythms of both sun and moon.  
  Address Max Perutz Labs, University of Vienna, Vienna BioCenter, Dr. Bohr-Gasse 9/4, A-1030 Vienna; Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter, Dr. Bohr-Gasse 9/4, A-1030 Vienna. Electronic address: kristin.tessmar@mfpl.ac.at  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-2836 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32198116 Approved no  
  Call Number GFZ @ kyba @ Serial 2865  
Permanent link to this record
 

 
Author (up) Anisimov, V. N. url  openurl
  Title Light desynchronosis and health Type Journal Article
  Year 2019 Publication Light & Engineering Abbreviated Journal  
  Volume 27 Issue 3 Pages 14-25  
  Keywords Human Health; Review  
  Abstract The review summarizes the modern knowledge of the impact of day-night, light-darkness rhythm disorders on the aging process and on the risk of development of the age-related conditions. Significant evidence has been obtained of that the constant artificial illumination and the daylight of the North has a stimulating effect on the occurrence and development of tumours in laboratory animals. It has been shown that long-term shift work, trans-meridian flights (jet-lag) and insomnia increase the risk of cardiovascular diseases, diabetes mellitus, and malignancies in humans. Particular attention is given to the studies where the relationship between light intensity, light wavelength and its ability to suppress the synthesis of melatonin produced at night in the pineal gland, are investigated. It has been established that melatonin synthesis is most effectively suppressed with blue light sources of a wavelength from 446 to 477 nm. The use of exogenous melatonin prevents premature aging of the reproductive system and the body as a whole prevents the development of immune-suppression, metabolic syndrome and tumours caused by light pollution. An urgent task is to develop recommendations for optimizing the illumination of workplaces and residential premises, of cities and towns as a prevention measure for premature aging and age-related pathology, which, ultimately, will contribute to the long-term maintaining of performance and improving the quality of life.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ intern @ Serial 2642  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: