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Author Sletten, T.L.; Cappuccio, F.P.; Davidson, A.J.; Van Cauter, E.; Rajaratnam, S.M.W.; Scheer, F.A.J.L.
Title Health consequences of circadian disruption Type Journal Article
Year 2020 Publication Sleep Abbreviated Journal Sleep
Volume 43 Issue 1 Pages (up)
Keywords Human Health; Circadian Rhythm; Chronobiology; Sleep; Review
Abstract The circadian system is key for optimal functioning by maintaining synchrony between internal circadian rhythms, behaviors, and external cues. Many clinicians are not fully aware, however, of the far-reaching implications of the circadian system for human health. Clinical attention to circadian rhythms has largely focused on sleep disturbances. The impact of the circadian system on health is, however, much broader. Clinical diagnoses are often based on single time point assessments during the day, ignoring circadian influences on physiology. Even when time is considered, using (external) clock time ignores the large interindividual differences in internal timing.
Address Division of Sleep Medicine, Harvard Medical School, Boston, MA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0161-8105 ISBN Medium
Area Expedition Conference
Notes PMID:31930347 Approved no
Call Number IDA @ john @ Serial 2822
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Author Ritonja, J.; McIsaac, M.A.; Sanders, E.; Kyba, C.C.M.; Grundy, A.; Cordina-Duverger, E.; Spinelli, J.J.; Aronson, K.J.
Title Outdoor light at night at residences and breast cancer risk in Canada Type Journal Article
Year 2020 Publication European Journal of Epidemiology Abbreviated Journal Eur J Epidemiol
Volume in press Issue Pages (up)
Keywords Human Health; Breast cancer; Case-control study; Circadian disruption; Light at night; Night work; Women's health
Abstract Experimental and epidemiologic studies suggest that light at night (LAN) exposure disrupts circadian rhythm, and this disruption may increase breast cancer risk. We investigated the potential association between residential outdoor LAN and breast cancer risk. A population-based case-control study was conducted in Vancouver, British Columbia and Kingston, Ontario, Canada with incident breast cancer cases, and controls frequency matched by age in the same region. This analysis was restricted to 844 cases and 905 controls who provided lifetime residential histories. Using time-weighted average duration at each home 5-20 years prior to study entry, two measures of cumulative average outdoor LAN were calculated using two satellite data sources. Logistic regression was used to estimate the relationship between outdoor LAN and breast cancer risk, considering interactions for menopausal status and night shift work. We found no association between residential outdoor LAN and breast cancer for either measure of LAN [OR comparing highest vs. lowest tertile (DNB) = 0.95, 95% CI 0.70-1.27]. We also found no association when considering interactions for menopausal status and past/current night work status. These findings were robust to changes to years of residential data considered, residential mobility, and longer exposure windows. Our findings are consistent with studies reporting that outdoor LAN has a small effect or no effect on breast cancer risk.
Address Division of Cancer Care and Epidemiology, Cancer Research Institute, Queen's University, Kingston, ON, Canada. aronson@queensu.ca
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0393-2990 ISBN Medium
Area Expedition Conference
Notes PMID:32026169 Approved no
Call Number GFZ @ kyba @ Serial 2826
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Author Yue, F.; Xia, K.; Wei, L.; Xing, L.; Wu, S.; Shi, Y.; Man, L.S.; Shui, G.; Xiang, X.; Russell, R.; Zhang, D.
Title Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats Type Journal Article
Year 2020 Publication Journal of Gastroenterology and Hepatology Abbreviated Journal J Gastroenterol Hepatol
Volume in press Issue Pages (up)
Keywords Animals; apoptosis; ceramide; light pollution; non-alcoholic fatty liver disease; sphingolipids
Abstract BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern worldwide. With the progression of urbanization, light pollution is becoming an inevitable risk factor for NAFLD. However, the role of light pollution on NAFLD is insufficiently understood, and the underlying mechanism remains unclear. The present study explored effects of constant light exposure on NAFLD and elucidated its related mechanisms. METHODS: Thirty-two male SD rats were divided into 4 groups (n=8 each): 1) rats on a normal diet exposed to standard light-dark cycle (ND-LD); 2) rats on a normal diet exposed to constant light (ND-LL); 3) rats on a high fat diet exposed to standard light-dark cycle (HFD-LD); 4) and rats on a high fat diet exposed to constant light (HFD-LL). After 12 weeks treatment, rats were sacrificed and pathophysiological assessments were performed. Targeted lipidomics was used to measure sphingolipids, including ceramides, glucosylceramides and lactosylceramides, sphingomyelins and sphingosine-1-phosphates in plasma and liver tissues. RESULTS: In normal chow rats, constant light exposure led to glucose abnormalities and dyslipidemia. In high-fat fed rats, constant light exposure exacerbated glucose abnormalities, dyslipidemia, insulin resistance, inflammation and aggravated steatohepatitis. Compared to HFD-LD rats, HFD-LL had decreased plasma sphingosine-1-phosphate and elevated liver concentrations of total ceramides and specific ceramide species (ceramide d18:0/24:0, ceramide d18:1/22:0, ceramide d18:1/24:0 and ceramide d18:1/24:1), and which were associated with increased hepatocyte apoptosis. CONCLUSIONS: Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats.
Address Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0815-9319 ISBN Medium
Area Expedition Conference
Notes PMID:32027419 Approved no
Call Number GFZ @ kyba @ Serial 2829
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Author Wu, Y.; Jiang, M.; Chang, Z.; Li, Y.; Shi, K.
Title Does China's Urban Development Satisfy Zipf's Law? A Multiscale Perspective from the NPP-VIIRS Nighttime Light Data Type Journal Article
Year 2020 Publication International Journal of Environmental Research and Public Health Abbreviated Journal Int J Environ Res Public Health
Volume 17 Issue 4 Pages (up)
Keywords Remote Sensing; China; Zipf's law; multiscale analysis; nighttime lights; urban development
Abstract Currently, whether the urban development in China satisfies Zipf's law across different scales is still unclear. Thus, this study attempted to explore whether China's urban development satisfies Zipf's law across different scales from the National Polar-Orbiting Partnership's Visible Infrared Imaging Radiometer Suite (NPP-VIIRS) nighttime light data. First, the NPP-VIIRS data were corrected. Then, based on the Zipf law model, the corrected NPP-VIIRS data were used to evaluate China's urban development at multiple scales. The results showed that the corrected NPP-VIIRS data could effectively reflect the state of urban development in China. Additionally, the Zipf index (q) values, which could express the degree of urban development, decreased from 2012 to 2018 overall in all provinces, prefectures, and counties. Since the value of q was relatively close to 1 with an R(2) value > 0.70, the development of the provinces and prefectures was close to the ideal Zipf's law state. In all counties, q > 1 with an R(2) value > 0.70, which showed that the primate county had a relatively stronger monopoly capacity. When the value of q < 1 with a continuous declination in the top 2000 counties, the top 250 prefectures, and the top 20 provinces in equilibrium, there was little difference in the scale of development at the multiscale level with an R(2) > 0.90. The results enriched our understanding of urban development in terms of Zipf's law and had valuable implications for relevant decision-makers and stakeholders.
Address Chongqing Engineering Research Centre for Remote Sensing Big Data Application, School of Geographical Sciences, Southwest University, Chongqing 400715, China
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1660-4601 ISBN Medium
Area Expedition Conference
Notes PMID:32102480 Approved no
Call Number GFZ @ kyba @ Serial 2832
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Author Qiang, Y.; Huang, Q.; Xu, J.
Title Observing Community Resilience from Space: Using Nighttime Lights to Model Economic Disturbance and Recovery Pattern in Natural Disaster Type Journal Article
Year 2020 Publication Sustainable Cities and Society Abbreviated Journal Sustainable Cities and Society
Volume in press Issue Pages (up)
Keywords Remote Sensing
Abstract A major challenge for measuring community resilience is the lack of empirical observation in disasters. As an effective tool for observing human activities on the earth surface, night-time light (NTL) remote sensing images can fill the gap of empirical data for measuring community resilience in natural disasters. This study introduces a quantitative framework to model the recovery pattern of economic activity in a natural disaster using the Defense Meteorological Satellite Program-Operational Linescan System (DMSP-OLS) images. The utility of the framework is demonstrated in a case study of Hurricane Katrina, which uncovered the great economic impact of Katrina and spatial variation of the disturbance and recovery pattern of economic activity. Environmental and socio-economic factors that potentially influence the economic recovery were explored in statistical analyses. Instead of a static and holistic index, the framework measures resilience as a dynamic process. The analysis results provide actionable information for prompting resilience in diverse communities and in different phases of a disaster. In addition to Hurricane Katrina, the resilience modeling framework is applicable for other disaster types. The introduced approaches and findings increase our understanding about the complexity of community resilience and provide support for developing resilient and sustainable communities.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2210-6707 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2833
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