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Author Alamús, R.; Bará, S.; Corbera, J.; Escofet, J.; Palà , V.; Pipia, L.; Tardà, A. url  doi
openurl 
  Title Ground-based hyperspectral analysis of the urban nightscape Type Journal Article
  Year 2017 Publication ISPRS Journal of Photogrammetry and Remote Sensing Abbreviated Journal ISPRS Journal of Photogrammetry and Remote Sensing  
  Volume 124 Issue (up) Pages 16-26  
  Keywords Instrumentation; Remote Sensing  
  Abstract Airborne hyperspectral cameras provide the basic information to estimate the energy wasted skywards by outdoor lighting systems, as well as to locate and identify their sources. However, a complete characterization of the urban light pollution levels also requires evaluating these effects from the city dwellers standpoint, e.g. the energy waste associated to the excessive illuminance on walls and pavements, light trespass, or the luminance distributions causing potential glare, to mention but a few. On the other hand, the spectral irradiance at the entrance of the human eye is the primary input to evaluate the possible health effects associated with the exposure to artificial light at night, according to the more recent models available in the literature. In this work we demonstrate the possibility of using a hyperspectral imager (routinely used in airborne campaigns) to measure the ground-level spectral radiance of the urban nightscape and to retrieve several magnitudes of interest for light pollution studies. We also present the preliminary results from a field campaign carried out in the downtown of Barcelona.  
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  Series Volume Series Issue Edition  
  ISSN 0924-2716 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1613  
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Author Wang, H.-B.; Whittaker, D.S.; Truong, D.; Mulji, A.K.; Ghiani, C.A.; Loh, D.H.; Colwell, C.S. url  doi
openurl 
  Title Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease Type Journal Article
  Year 2017 Publication Neurobiology of Sleep and Circadian Rhythms Abbreviated Journal Neurobiology of Sleep and Circadian Rhythms  
  Volume 2 Issue (up) Pages 39-52  
  Keywords animals; Human Health  
  Abstract Patients with Huntington's disease (HD) exhibit movement disorders, psychiatric disturbance and cognitive impairments as the disease progresses. Abnormal sleep/wake cycles are common among HD patients with reports of delayed sleep onset, fatigue during the day, and a delayed pattern of melatonin secretion all of which suggest circadian dysfunction. Mouse models of HD confirm disrupted circadian rhythms with pathophysiology found in the central circadian clock (suprachiasmatic nucleus). Importantly, circadian dysfunction manifests early in disease, even before the classic motor symptoms, in both patients and mouse models. Therefore, we hypothesize that the circadian dysfunction may interact with the disease pathology and exacerbate the HD symptoms. If correct, early intervention may benefit patients and delay disease progression. One test of this hypothesis is to determine whether light therapy designed to strengthen this intrinsic timing system can delay the disease progression in mouse models. Therefore, we determined the impact of blue wavelength-enriched light on two HD models: the BACHD and Q175 mice. Both models received 6 hours of blue-light at the beginning of their daily light cycle for 3 months. After treatment, both genotypes showed improvements in their locomotor activity rhythm without significant change to their sleep behavior. Critically, treated mice of both lines exhibited improved motor performance compared to untreated controls. Focusing on the Q175 genotype, we sought to determine whether the treatment altered signaling pathways in brain regions known to be impacted by HD using NanoString gene expression assays. We found that the expression of several HD relevant markers was altered in the striatum and cortex of the treated mice. Our study demonstrates that strengthening the circadian system can delay the progression of HD in pre-clinical models. This work suggests that lighting conditions should be considered when managing treatment of HD and other neurodegenerative disorders.  
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  Series Volume Series Issue Edition  
  ISSN 2451-9944 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1626  
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Author Alzahrani, H.S.; Khuu, S.K.; Roy, M. url  doi
openurl 
  Title Modelling the effect of commercially available blue-blocking lenses on visual and non-visual functions Type Journal Article
  Year 2019 Publication Clinical & Experimental Optometry Abbreviated Journal Clin Exp Optom  
  Volume in press Issue (up) Pages  
  Keywords Human Health; blue-blocking lenses; non-visual functions; transmittance; visual functions  
  Abstract BACKGROUND: Blue-blocking lenses (BBLs) are marketed as providing retinal protection from acute and cumulative exposure to blue light over time. The selective reduction in visible wavelengths transmitted through BBLs is known to influence the photosensitivity of retinal photoreceptors, which affects both visual and non-visual functions. This study measured the spectral transmittance of BBLs and evaluated their effect on blue perception, scotopic vision, circadian rhythm, and protection from photochemical retinal damage. METHODS: Seven different types of BBLs from six manufacturers and untinted control lenses with three different powers (+2.00 D, -2.00 D and Plano) were evaluated. The whiteness index of BBLs used in this study was calculated using Commission International de l'Eclairage (CIE) Standard Illuminates D65, and CIE 1964 Standard with a 2 degrees Observer. The protective qualities of BBLs and their effect on blue perception, scotopic vision, and circadian rhythm were evaluated based on their spectral transmittance, which was measured with a Cary 5,000 UV-Vis-NIR spectrophotometer. RESULTS: BBLs were found to reduce blue light (400-500 nm) by 6-43 per cent, providing significant protection from photochemical retinal damage compared to control lenses (p </= 0.05). All BBLs were capable of reducing the perception of blue colours, scotopic sensitivities and circadian sensitivities by 5-36 per cent, 5-24 per cent, and 4-27 per cent, respectively depending on the brand and power of the lens. CONCLUSION: BBLs can provide some protection to the human eye from photochemical retinal damage by reducing a portion of blue light that may affect visual and non-visual performances, such as those critical to scotopic vision, blue perception, and circadian rhythm.  
  Address School of Optometry and Vision Science, The University of New South Wales, Sydney, Australia  
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  Series Volume Series Issue Edition  
  ISSN 0816-4622 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31441122 Approved no  
  Call Number GFZ @ kyba @ Serial 2654  
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Author Rahman, S.A.; St Hilaire, M.A.; Lockley, S.W. url  doi
openurl 
  Title The effects of spectral tuning of evening ambient light on melatonin suppression, alertness and sleep Type Journal Article
  Year 2017 Publication Physiology & Behavior Abbreviated Journal Physiol Behav  
  Volume 177 Issue (up) Pages 221-229  
  Keywords Human Health  
  Abstract We compared the effects of bedroom-intensity light from a standard fluorescent and a blue- (i.e., short-wavelength) depleted LED source on melatonin suppression, alertness, and sleep. Sixteen healthy participants (8 females) completed a 4-day inpatient study. Participants were exposed to blue-depleted circadian-sensitive (C-LED) light and a standard fluorescent light (FL, 4100K) of equal illuminance (50lx) for 8h prior to a fixed bedtime on two separate days in a within-subject, randomized, cross-over design. Each light exposure day was preceded by a dim light (<3lx) control at the same time 24h earlier. Compared to the FL condition, control-adjusted melatonin suppression was significantly reduced. Although subjective sleepiness was not different between the two light conditions, auditory reaction times were significantly slower under C-LED conditions compared to FL 30min prior to bedtime. EEG-based correlates of alertness corroborated the reduced alertness under C-LED conditions as shown by significantly increased EEG spectral power in the delta-theta (0.5-8.0Hz) bands under C-LED as compared to FL exposure. There was no significant difference in total sleep time (TST), sleep efficiency (SE%), and slow-wave activity (SWA) between the two conditions. Unlike melatonin suppression and alertness, a significant order effect was observed on all three sleep variables, however. Individuals who received C-LED first and then FL had increased TST, SE% and SWA averaged across both nights compared to individuals who received FL first and then C-LED. These data show that the spectral characteristics of light can be fine-tuned to attenuate non-visual responses to light in humans.  
  Address Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, United States; Division of Sleep and Circadian Disorders, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, United States  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0031-9384 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28472667 Approved no  
  Call Number LoNNe @ kyba @ Serial 1659  
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Author Russart, K.L.G.; Nelson, R.J. url  doi
openurl 
  Title Light at night as an environmental endocrine disruptor Type Journal Article
  Year 2018 Publication Physiology & Behavior Abbreviated Journal Physiol Behav  
  Volume 190 Issue (up) Pages 82-89  
  Keywords Human Health; Animals  
  Abstract Environmental endocrine disruptors (EEDs) are often consequences of human activity; however, the effects of EEDs are not limited to humans. A primary focus over the past approximately 30years has been on chemical EEDs, but the repercussions of non-chemical EEDs, such as artificial light at night (LAN), are of increasing interest. The sensitivity of the circadian system to light and the influence of circadian organization on overall physiology and behavior make the system a target for disruption with widespread effects. Indeed, there is increasing evidence for a role of LAN in human health, including disruption of circadian regulation and melatonin signaling, metabolic dysregulation, cancer risk, and disruption of other hormonally-driven systems. These effects are not limited to humans; domesticated animals as well as wildlife are also exposed to LAN, and at risk for disrupted circadian rhythms. Here, we review data that support the role of LAN as an endocrine disruptor in humans to be considered in treatments and lifestyle suggestions. We also present the effects of LAN in other animals, and discuss the potential for ecosystem-wide effects of artificial LAN. This can inform decisions in agricultural practices and urban lighting decisions to avoid unintended outcomes.  
  Address Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0031-9384 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28870443 Approved no  
  Call Number LoNNe @ kyba @ Serial 1719  
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