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Author Madahi, P.-G.; Ivan, O.; Adriana, B.; Diana, O.; Carolina, E. url  doi
openurl 
  Title Constant light during lactation programs circadian and metabolic systems Type Journal Article
  Year 2018 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume 35 Issue 8 Pages 1153-1167  
  Keywords (up) Animals  
  Abstract Exposure to light at night is a disruptive condition for the adult circadian system, leading to arrhythmicity in nocturnal rodents. Circadian disruption is a risk factor for developing physiological and behavioral alterations, including weight gain and metabolic disease. During early stages of development, the circadian system undergoes a critical period of adjustment, and it is especially vulnerable to altered lighting conditions that may program its function, leading to long-term effects. We hypothesized that during lactation a disrupted light-dark cycle due to light at night may disrupt the circadian system and in the long term induce metabolic disorders. Here we explored in pups, short- and long-term effects of constant light (LL) during lactation. In the short term, LL caused a loss of rhythmicity and a reduction in the immunopositive cells of VIP, AVP, and PER1 in the suprachiasmatic nucleus (SCN). In the short term, the affection on the circadian clock in the pups resulted in body weight gain, loss of daily rhythms in general activity, plasma glucose and triglycerides (TG). Importantly, the DD conditions during development also induced altered daily rhythms in general activity and in the SCN. Exposure to LD conditions after lactation did not restore rhythmicity in the SCN, and the number of immunopositve cells to VIP, AVP, and PER1 remained reduced. In the long term, daily rhythmicity in general activity was restored; however, daily rhythms in glucose and TG remained disrupted, and daily mean levels of TG were significantly increased. Present results point out the programming role played by the LD cycle during early development in the function of the circadian system and on metabolism. This study points out the risk represented by exposure to an altered light-dark cycle during early stages of development. ABBREVIATIONS: AVP: arginine vasopressin peptide; CRY: cryptochrome; DD: constant darkness; DM: dorsomedial; LD: light-dark cycle; LL: constant light; NICUs: neonatal intensive care units; P: postnatal days; PER: period; S.E.M.: standard error of the mean; SCN: suprachiasmatic nucleus; TG: triglycerides; VIP: vasointestinal peptide; VL: ventrolateral; ZT: zeitgeber time.  
  Address a Facultad de Medicina , Universidad Nacional Autonoma de Mexico, UNAM , Mexico City , Mexico  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29688088 Approved no  
  Call Number GFZ @ kyba @ Serial 1884  
Permanent link to this record
 

 
Author McLay, L.K.; Nagarajan-Radha, V.; Green, M.P.; Jones, T.M. url  doi
openurl 
  Title Dim artificial light at night affects mating, reproductive output, and reactive oxygen species in Drosophila melanogaster Type Journal Article
  Year 2018 Publication Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology Abbreviated Journal J Exp Zool A Ecol Integr Physiol  
  Volume 329 Issue 8-9 Pages 419-428  
  Keywords (up) Animals  
  Abstract Humans are lighting the night-time environment with ever increasing extent and intensity, resulting in a variety of negative ecological effects in individuals and populations. Effects of light at night on reproductive fitness traits are demonstrated across taxa however, the mechanisms underlying these effects are largely untested. One possible mechanism is that light at night may result in perturbed reactive oxygen species (ROS) and oxidative stress levels. Here, we reared Drosophila melanogaster under either dim (10 lx) light or no light (0 lx) at night for three generations and then compared mating and lifetime oviposition patterns. In a second experiment, we explored whether exposure to light at night treatments resulted in variation in ROS levels in the heads and ovaries of six, 23- and 36-day-old females. We demonstrate that dim light at night affects mating and reproductive output: 10 lx flies courted for longer prior to mating, and female oviposition patterns differed to 0 lx females. ROS levels were lower in the ovaries but not heads, of 10 lx compared with 0 lx females. We suggest that reduced ROS levels may reflect changes in ovarian physiology and cell signaling, which may be related to the differences observed in oviposition patterns. Taken together, our results indicate negative consequences for invertebrates under more stressful, urban, lit conditions and further investigation into the mechanisms driving these changes is warranted to manage invertebrate communities in a brighter future.  
  Address School of BioSciences, Faculty of Science, The University of Melbourne, Melbourne, Victoria, Australia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2471-5638 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29733537 Approved no  
  Call Number GFZ @ kyba @ Serial 1889  
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Author Borck, P.C.; Batista, T.M.; Vettorazzi, J.F.; Soares, G.M.; Lubaczeuski, C.; Guan, D.; Boschero, A.C.; Vieira, E.; Lazar, M.A.; Carneiro, E.M. url  doi
openurl 
  Title Nighttime light exposure enhances Rev-erbalpha-targeting microRNAs and contributes to hepatic steatosis Type Journal Article
  Year 2018 Publication Metabolism: Clinical and Experimental Abbreviated Journal Metabolism  
  Volume 85 Issue Pages 250-258  
  Keywords (up) Animals  
  Abstract OBJECTIVE: The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms. RESULTS: We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbalpha and up-regulation of its lipogenic targets ACL and FAS in liver. Furthermore, the expression of Rev-erbalpha-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group. Consistently, overexpression of these miRNAs in primary hepatocytes reduced Rev-erbalpha expression at the mRNA and protein levels. Importantly, overexpression of Rev-erbalpha-targeting miRNAs increased mRNA levels of Acly and Fasn. CONCLUSION: Thus, altered miRNA profile is an important mechanism underlying the disruption of the peripheral clock caused by exposure to ALAN, which could lead to hepatic steatosis.  
  Address Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil; Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, SP, Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0026-0495 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29751019 Approved no  
  Call Number GFZ @ kyba @ Serial 1891  
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Author Jong, M. de; Eertwegh, L. van den; Beskers, R.E.; Vries, P.P. de; Spoelstra, K.; Visser, M.E. url  doi
openurl 
  Title Timing of Avian Breeding in an Urbanised World Type Journal Article
  Year 2018 Publication Ardea Abbreviated Journal Ardea  
  Volume 106 Issue 1 Pages 31-38  
  Keywords (up) Animals  
  Abstract A large part of the world is urbanised, and the process of urbanisation is ongoing. This causes dramatic alterations of species' habitat such as increased night light, sound levels and temperature, along with direct disturbance by human activity. We used eight years of citizen science data from ten common bird species breeding in nest boxes throughout The Netherlands to study the relationship between urbanisation and a key life history trait, timing of breeding. We used nightly light levels in the form of sky brightness and light emission as a proxy for urbanisation as the dramatic change of the night-time environment is a prominent effect of urbanisation. We expected birds to lay earlier in areas with more light at night, i.e. in more urbanised areas. We found, however, no relationship between light levels and seasonal timing in the ten species studied. A limitation of our study is that there was only limited data for the areas that were urbanised most (e.g. inside cities). Most nest box study areas are located in areas with a limited level of urbanisation, and hence with relatively low light levels of light at night. The lack of data on breeding birds in more urbanised environments, which is a rapidly expanding habitat for an increasing number of species worldwide, should be the focus of attention and citizen science would be highly suitable to also provide data for such areas.  
  Address  
  Corporate Author Thesis  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0373-2266 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 1893  
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Author Shen, J.; Zhu, X.; Gu, Y.; Zhang, C.; Huang, J.; Qing, X. url  doi
openurl 
  Title Toxic effect of visible light on Drosophila lifespan depending upon diet protein content Type Journal Article
  Year 2018 Publication The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences Abbreviated Journal J Gerontol A Biol Sci Med Sci  
  Volume 74 Issue 2 Pages 163-167  
  Keywords (up) Animals  
  Abstract We investigated the toxic effect of visible light on Drosophila lifespan in both sexes. The toxic effect of ultraviolet (UV) light on organisms is well known. However, the effects of illumination with visible light remain unclear. Here, we found that visible light could be toxic to Drosophila survival, depending on the protein content in diet. In addition, further analysis revealed significant interaction between light and sex, and showed that strong light shortened life span by causing opposite direction changes in mortality rate parameters in females versus males. Our findings suggest that photoageing may be a general phenomenon, and support the theory of sexual antagonistic pleiotropy in aging intervention. The results caution that exposure to visible light could be hazardous to life span and suggest that identification of the underlying mechanism would allow better understanding of aging intervention.  
  Address College of Life Information Science & Instrument Engineering, Hangzhou Dianzi University, Hangzhou, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1079-5006 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29506144 Approved no  
  Call Number GFZ @ kyba @ Serial 1903  
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