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Author Abbott, S.M.; Malkani, R.G.; Zee, P.C.
Title Circadian disruption and human health: A bidirectional relationship Type Journal Article
Year 2018 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci
Volume in press Issue Pages
Keywords Human Health; Review
Abstract Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep-wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine.
Address Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
Corporate Author Thesis
Publisher Place of Publication Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0953-816X ISBN Medium
Area Expedition Conference
Notes PMID:30549337 Approved no
Call Number GFZ @ kyba @ Serial 2154
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Author Shor, E.; Potavskaya, R.; Kurtz, A.; Paik, I.; Huq, E.; Green, R.
Title PIF-mediated sucrose regulation of the circadian oscillator is light quality and temperature dependent Type Journal Article
Year 2018 Publication Genes Abbreviated Journal Genes (Basel)
Volume 9 Issue 12 Pages
Keywords Plants
Abstract Studies are increasingly showing that metabolic and circadian (~24 h) pathways are strongly interconnected, with the circadian system regulating the metabolic state of the cell, and metabolic products feeding back to entrain the oscillator. In plants, probably the most significant impact of the circadian system on metabolism is in its reciprocal regulation of photosynthesis; however, the pathways by which this occurs are still poorly understood. We have previously shown that members of the basic helix-loop-helix (bHLH) transcription factor PHYTOCHROME INTERACTING FACTOR (PIF) family are involved in the photosynthate entrainment of the circadian oscillator. In this paper, using Arabidopsis mutants and overexpression lines, we examine how temperature and light quality affect PIF-mediated sucrose signaling to the oscillator and examine the contributions of individual PIF members. Our results also show that the quality of light is important for PIF signaling, with red and blue lights having the opposite effects, and that temperature affects PIF-mediated sucrose signaling. We propose the light sensitivity of PIF-mediated sucrose entrainment of the oscillator may be important in enabling plants to distinguish between sucrose produced de novo from photosynthesis during the day and the sucrose products of starch degradation at the end of the night.
Address Department of Plant and Environmental Sciences, Institute for Life Sciences, Edmond J. Safra Campus, Givat Ram, Hebrew University, Jerusalem 91904, Israel. rgreen@mail.huji.ac.il
Corporate Author Thesis
Publisher Place of Publication Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2073-4425 ISBN Medium
Area Expedition Conference
Notes PMID:30551669; PMCID:PMC6316277 Approved no
Call Number GFZ @ kyba @ Serial 2155
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Author Erren, T.C.; Lewis, P.
Title Hypothesis: ubiquitous circadian disruption can cause cancer Type Journal Article
Year 2019 Publication European Journal of Epidemiology Abbreviated Journal Eur J Epidemiol
Volume 34 Issue 1 Pages 1-4
Keywords Human Health
Abstract Circadian disruption (CD) was implicated in chains of cancer causation when the International Agency for Research on Cancer classified shift-work involving circadian disruption as probably carcinogenic in 2007. In the following decade, epidemiological studies into causal concepts associated with circadian disruption were inconclusive. Unappreciated complexity with an exclusive focus on shift-work, light-at-night, sleep, and melatonin in regard to circadian disruption may be accountable. With compelling non-epidemiological evidence, we posit that ubiquitous circadian disruption causes cancer and, moreover, that this is unexplored epidemiologically. This hypothesis offers a novel explanation why numerous studies in shift-workers evince inconsistent results: If circadian disruption is a ubiquitous causal phenomenon, confining assessments to the workplace, ignoring circadian disruption at play, and potential misclassification of 'who' is 'when' and 'how much' exposed to circadian disruption may disallow detecting the existence and magnitude of cancer risks. The rationale herein provides plausible explanations for previous observations and makes falsifiable predictions.
Address Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of Cologne, Cologne, Germany. philip.lewis@uk-koeln.de
Corporate Author Thesis
Publisher Place of Publication Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0393-2990 ISBN Medium
Area Expedition Conference
Notes PMID:30547255 Approved no
Call Number GFZ @ kyba @ Serial 2156
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Author Stern, M.; Broja, M.; Sansone, R.; Grone, M.; Skene, S.S.; Liebmann, J.; Suschek, C.V.; Born, M.; Kelm, M.; Heiss, C.
Title Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans Type Journal Article
Year 2018 Publication European Journal of Preventive Cardiology Abbreviated Journal Eur J Prev Cardiol
Volume 25 Issue 17 Pages 1875-1883
Keywords Human Health; Blue light; blood pressure; endothelial function; forearm blood flow; pulse wave velocity
Abstract AIMS: Previous studies have shown that ultraviolet light can lead to the release of nitric oxide from the skin and decrease blood pressure. In contrast to visible light the local application of ultraviolet light bears a cancerogenic risk. Here, we investigated whether whole body exposure to visible blue light can also decrease blood pressure and increase endothelial function in healthy subjects. METHODS: In a randomised crossover study, 14 healthy male subjects were exposed on 2 days to monochromatic blue light or blue light with a filter foil (control light) over 30 minutes. We measured blood pressure (primary endpoint), heart rate, forearm vascular resistance, forearm blood flow, endothelial function (flow-mediated dilation), pulse wave velocity and plasma nitric oxide species, nitrite and nitroso compounds (secondary endpoints) during and up to 2 hours after exposure. RESULTS: Blue light exposure significantly decreased systolic blood pressure and increased heart rate as compared to control. In parallel, blue light significantly increased forearm blood flow, flow-mediated dilation, circulating nitric oxide species and nitroso compounds while it decreased forearm vascular resistance and pulse wave velocity. CONCLUSION: Whole body irradiation with visible blue light at real world doses improves blood pressure, endothelial function and arterial stiffness by nitric oxide released from photolabile intracutanous nitric oxide metabolites into circulating blood.
Address Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford GU2 7XH, UK. Email: c.heiss(at)
Corporate Author Thesis
Publisher SAGE Place of Publication Editor
Language (down) English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2047-4873 ISBN Medium
Area Expedition Conference
Notes PMID:30196723 Approved no
Call Number IDA @ john @ Serial 2157
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Author Farghly, M.F.; Mahrose, K.M.; Ahmad, E.A.M.; Rehman, Z.U.; Yu, S.
Title Implementation of different feeding regimes and flashing light in broiler chicks Type Journal Article
Year 2019 Publication Poultry Science Abbreviated Journal Poult Sci
Volume 98 Issue 5 Pages 2034-2042
Keywords Animals
Abstract A 3 x 2 factorial arrangement was implemented to determine the performance of 450 Cobb broilers subjected to different feeding regimes with and without lighting programs. The chicks were divided into 3 groups according to the feeding regime (ad libitum, restricted, or intermittent), and each group was reared under one of two lighting programs (100% continuous light or 50% continuous light and 50% flashing light). The results showed that the broilers under the ad libitum and intermittent feeding regimes had superior body weight (BW) and average daily gain (ADG) values and the lowest feed conversion ratio (FCR) at 3 and 6 wk of age. Broilers exposed to flashing light and an intermittent feeding regime had the highest BW and ADG values and the lowest FCR. Birds exposed to intermittent feeding had the highest dressed carcass weight and the lowest heart weight. Broilers reared with flashing light had higher tenderness and juiciness values than the other groups. Broilers subjected to a restricted feeding regime and flashing light had the lowest abdominal fat values of all the groups. Tenderness and juiciness were significantly higher in broilers subjected to the ad libitum feeding regime x flashing light and the intermittent feeding regime x flashing light. Broilers fed an intermittent regime had the lowest spleen %, heterophil, heterophil to lymphocyte (H/L) ratio and body temperature values of all the groups, and broilers reared under the intermittent regime x flashing light had the lowest spleen %, H/L ratio and body temperature values. Non-significant differences in all health aspects (shank length, keel bone length, foot pad burns, breast blisters score, hock discoloration, and mortality) were observed among the experimental groups. In conclusion, intermittent and restricted feeding regimes and a flashing lighting program improved the FCR and did not produce any adverse effects on performance or physiological parameters. The results of this work show that intermittent feeding and flashing lighting programs are more beneficial to broiler management.
Address Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai 200241, China
Corporate Author Thesis
Publisher Place of Publication Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0032-5791 ISBN Medium
Area Expedition Conference
Notes PMID:30615175 Approved no
Call Number GFZ @ kyba @ Serial 2158
Permanent link to this record