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Author Shinobu Yasuo, Ayaka Iwamoto, Sang-il Lee, Shotaro Ochiai, Rina Hitachi, Satomi Shibata, Nobuo Uotsu, Chie Tarumizu, Sayuri Matsuoka, Mitsuhiro Furuse, Shigekazu Higuchi url  doi
openurl 
  Title L-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans Type Journal Article
  Year 2017 Publication Journal of Nutrition Abbreviated Journal  
  Volume 147 Issue 12 Pages 2347-2355  
  Keywords Animals; Human Health  
  Abstract Background: The circadian clock is modulated by the timing of ingestion or food composition, but the effects of specific nutrients are poorly understood.

Objective: We aimed to identify the amino acids that modulate the circadian clock and reset the light-induced circadian phase in mice and humans.

Methods: Male CBA/N mice were orally administered 1 of 20 L-amino acids, and the circadian and light-induced phase shifts of wheel-running activity were analyzed. Antagonists of several neurotransmitter pathways were injected before L-serine administration, and light-induced phase shifts were analyzed. In addition, the effect of L-serine on the light-induced phase advance was investigated in healthy male students (mean ± SD age 22.2 ± 1.8 y) by using dim-light melatonin onset (DLMO) determined by saliva samples as an index of the circadian phase.

Results: L-Serine administration enhanced light-induced phase shifts in mice (1.86-fold; P < 0.05). Both L-serine and its metabolite D-serine, a coagonist of N-methyl-D-aspartic acid (NMDA) receptors, exerted this effect, but D-serine concentrations in the hypothalamus did not increase after L-serine administration. The effect of L-serine was blocked by picrotoxin, an antagonist of &#947;-aminobutyric acid A receptors, but not by MK801, an antagonist of NMDA receptors. L-Serine administration altered the long-term expression patterns of clock genes in the suprachiasmatic nuclei. After advancing the light-dark cycle by 6 h, L-serine administration slightly accelerated re-entrainment to the shifted cycle. In humans, L-serine ingestion before bedtime induced significantly larger phase advances of DLMO after bright-light exposure during the morning (means ± SEMs—L-serine: 25.9 ± 6.6 min; placebo: 12.1 ± 7.0 min; P < 0.05).

Conclusion: These results suggest that L-serine enhances light-induced phase resetting in mice and humans, and it may be useful for treating circadian disturbances.
 
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  Call Number LoNNe @ kyba @ Serial 1784  
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Author Kozaki, Tomoaki; Taketomi, Ryunosuke; Hidaka ,Yuki; Ida, Nagisa; Yasuda, Takeo url  doi
openurl 
  Title Preventive Effect of Morning Bluish LED Light on Light-induced Melatonin Suppression at Night Type Journal Article
  Year 2018 Publication Journal of Science and Technology in Lighting Abbreviated Journal  
  Volume 41 Issue Pages 206-210  
  Keywords Human Health  
  Abstract Bright nocturnal light has been known to suppress melatonin secretion. However, bright light exposure during daytime might reduce light-induced melatonin suppression (LIMS) at night. This study aims to evaluate the effect of high correlated color temperature LED light during daytime on LIMS. Male participants were exposed to different light conditions for 3 h in the morning (09:00â??12:00). The light conditions were dim light (<10 lx), 125 lx high correlated color temperature (CCT) LED light, and 250 lx high CCT LED light. The subjects were then exposed to bright light (white light, 300 lx) for 1.5 h at night (01:00â??02:30). Saliva samples were taken before (01:00) and after (02:30) exposure for evaluation of melatonin secretion. There were no significant differences in melatonin secretion before and after night-time light exposure on the 125 lx and 250 lx morning light conditions. Since these light intensities were almost equal to those in our previous study, the high CCT LED light might be appropriate for certain work places (e.g., hospitals and underground spaces), contributing to the reduction of our health risk and also saving energy.  
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  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1785  
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Author Fotios, S.; Gibbons, R. url  doi
openurl 
  Title Road lighting research for drivers and pedestrians: The basis of luminance and illuminance recommendations Type Journal Article
  Year 2018 Publication Lighting Research & Technology Abbreviated Journal Lighting Research & Technology  
  Volume 50 Issue 1 Pages 154-186  
  Keywords Security; Public Safety; Lighting; Review  
  Abstract This article discusses quantitative recommendations for road lighting as given in guidelines and standards, primarily, the amount of light. The discussion is framed according to the type of road user, the driver and the pedestrian, these being the user groups associated with major and minor roads, respectively. Presented first is a brief history of road lighting standards, from early to current versions, and, where known, the basis of these standards. Recommendations for the amount of light do not appear to be well-founded in robust empirical evidence, or at least do not tend to reveal the nature of any evidence. This suggests a need to reconsider recommended light levels, a need reinforced by recent developments in the science and technology of lighting and of lighting research. To enable improved recommendations, there is a need for further evidence of the effects of changes in lighting: This article therefore discusses the findings of investigations, which might be considered when developing new standards.  
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  ISSN 1477-1535 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1790  
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Author Nelson, R.J.; DeVries, A.C. url  doi
openurl 
  Title Medical Hypothesis: Light at Night Is a Factor Worth Considering in Critical Care Units Type Journal Article
  Year 2017 Publication Advances in Integrative Medicine Abbreviated Journal Advances in Integrative Medicine  
  Volume 4 Issue 3 Pages 115-120  
  Keywords Human Health  
  Abstract Exposure to light at night is not an innocuous consequence of modernization. There are compelling data linking long-term exposure to occupational and environmental light at night with serious health conditions, including heart disease, obesity, diabetes, and cancer. However, far less is known about the physiological and behavioral effects of acute exposure to light at night. Among healthy volunteers, acute night-time light exposure increases systolic blood pressure and inflammatory markers in the blood, and impairs glucose regulation. Whether critically ill patients in a hospital setting experience the same physiological shifts in response to evening light exposure is not known. This paper reviews the available data on light at night effects on health and wellbeing, and argues that the data are sufficiently compelling to warrant studies of how lighting in intensive care units may be influencing patient recovery.  
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  Series Volume Series Issue Edition  
  ISSN 2212-9588 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1794  
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Author Bagan, H.; Borjigin, H.; Yamagata, Y. url  doi
openurl 
  Title Assessing nighttime lights for mapping the urban areas of 50 cities across the globe Type Journal Article
  Year 2018 Publication Environment and Planning B: Urban Analytics and City Science Abbreviated Journal Environment and Planning B: Urban Analytics and City Science  
  Volume Issue Pages 2399808317752926  
  Keywords Remote Sensing  
  Abstract Nighttime data from the Defense Meteorological Satellite Program Operational Linescan System have been widely used to map urban/built-up areas (hereafter referred to as “built-up area”), but to date there has not been a geographically comprehensive evaluation of the effectiveness of using nighttime lights data to map urban areas. We created accurate, convenient, and scalable grid cells based on Defense Meteorological Satellite Program/Operational Linescan System nighttime light pixels. We then calculated the density of Landsat-derived built-up areas within each grid cell. We explored the relationship between Defense Meteorological Satellite Program/Operational Linescan System nighttime lights data and the density of built-up areas to assess the utility of nighttime lights for mapping urban areas in 50 cities across the globe. We found that the brightness of nighttime lights was only in moderate agreement with the density of built-up areas; moreover, correlations between nighttime lights and Landsat-derived built-up areas were weak. Even in relatively sparsely populated urban regions (where the density of the built-up area is less than 20%), the highest correlation coefficient (R2) was only 0.4. Furthermore, nighttime lights showed lighted areas that extended beyond the area of large cities, and nighttime lights reduced the area of small cities. The results suggest that it is difficult to use the regression model to calibrate the Defense Meteorological Satellite Program/Operational Linescan System nighttime lights to fit urban built up areas.  
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  ISSN 2399-8083 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ kyba @; GFZ @ kyba @ Serial 1795  
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