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Author Willis, G.L.; Freelance, C.B.
Title The effect of directed photic stimulation of the pineal on experimental Parkinson's disease Type Journal Article
Year 2017 Publication Physiology & Behavior Abbreviated Journal Physiol Behav
Volume 182 Issue Pages 1-9
Keywords Animals
Abstract The role of the circadian system in Parkinson's disease (PD) is a topic of increasing scientific interest. This has emerged from recent studies demonstrating an altered response of PD patients to treatment in relation to the phase of the light/dark cycle and from other work defining the functional significance of melanocytes in PD: a cell type that the nigro-striatal dopamine (NSD) system and circadian system both contain. The present study was undertaken to determine the sensitivity of the pineal, as the final common pathway of the circadian system, to light delivered directly to the pineal via surgical implantation of LEDs. Direct photic stimulation of the pineal altered the course of experimental PD while anatomical controls receiving stimulation of the frontal cortex exhibited a negative impact on the course of recovery of these animals. These effects were closely linked to the phase of the light/dark cycle. The present results suggest that while pineal photoreceptors are regarded as vestigial, functional photo-reactivity of the pineal remains. It is inferred that melanocytes are the active cells responsible for the observed effect since they remain functionally intact in mammalian pineal even though pineal photoreceptors are functionally inert. Although the stimuli applied in the present study may be regarded as artificial this study demonstrates that brain parenchyma remains differentially reactive to direct light exposure and presents a novel mechanism in circadian structures that needs to be explored.
Address The Bronowski Institute of Behavioural Neuroscience, Coliban Medical Centre, 19 Jennings Street, Kyneton, Victoria 3444, Australia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9384 ISBN Medium
Area Expedition Conference
Notes PMID:28919247 Approved no
Call Number LoNNe @ kyba @ Serial 1732
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Author Henneken, J.; Jones, T.M.
Title Pheromones-based sexual selection in a rapidly changing world Type Journal Article
Year 2017 Publication Current Opinion in Insect Science Abbreviated Journal Current Opinion in Insect Science
Volume 24 Issue Pages 84-88
Keywords Animals
Abstract Insects utilise chemical cues for a range of different purposes and the complexity and degree of specificity of these signals is arguably unparalleled in the animal kingdom. Chemical signals are particularly important for insect reproduction and the selective pressures driving their evolution and maintenance have been the subject of previous reviews. However, the world in which chemical cues evolved and are maintained is changing at an unprecedented rate. How (or indeed whether) chemical signals used in sexual selection will respond is largely unknown. Here, we explore how recent increases in urbanisation and associated anthropogenic impacts may affect how chemical signals are produced and perceived. We focus on four anthropomorphic influences which have the potential to interact with pheromone-mediated sexual selection processes; climatic temperature shifts, exposure to chemical pollutants, the presence of artificial light at night and nutrient availability. Our aim is to provide a broad overview of key areas where the rapidly changing environment of the future might specifically affect pheromones utilised in sexual selection.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2214-5745 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1736
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Author Boswell, W.T.; Boswell, M.; Walter, D.J.; Navarro, K.L.; Chang, J.; Lu, Y.; Savage, M.G.; Shen, J.; Walter, R.B.
Title Exposure to 4100K fluorescent light elicits sex specific transcriptional responses in Xiphophorus maculatus skin Type Journal Article
Year 2018 Publication Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP Abbreviated Journal Comp Biochem Physiol C Toxicol Pharmacol
Volume 208 Issue Pages 96-104
Keywords Animals
Abstract It has been reported that exposure to artificial light may affect oxygen intake, heart rate, absorption of vitamins and minerals, and behavioral responses in humans. We have reported specific gene expression responses in the skin of Xiphophorus fish after exposure to ultraviolet light (UV), as well as, both broad spectrum and narrow waveband visible light. In regard to fluorescent light (FL), we have shown that male X. maculatus exposed to 4100K FL (i.e. “cool white”) rapidly suppress transcription of many genes involved with DNA replication and repair, chromosomal segregation, and cell cycle progression in skin. We have also detailed sex specific transcriptional responses of Xiphophorus skin after exposure to UVB. However, investigation of gender differences in global gene expression response after exposure to 4100K FL has not been reported, despite common use of this FL source for residential, commercial, and animal facility illumination. Here, we compare RNASeq results analyzed to assess changes in the global transcription profiles of female and male X. maculatus skin in response to 4100K FL exposure. Our results suggest 4100K FL exposure incites a sex-biased genetic response including up-modulation of inflammation in females and down modulation of DNA repair/replication in males. In addition, we identify clusters of genes that become oppositely modulated in males and females after FL exposure that are principally involved in cell death and cell proliferation.
Address Department of Chemistry and Biochemistry, Xiphophorus Genetic Stock Center, Texas State University, 601 University Drive, San Marcos, TX 78666, USA. Electronic address: RW12@txstate.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1532-0456 ISBN Medium
Area Expedition Conference
Notes PMID:28965926 Approved no
Call Number LoNNe @ kyba @ Serial 1739
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Author Gonzalez, T.J.; Lu, Y.; Boswell, M.; Boswell, W.; Medrano, G.; Walter, S.; Ellis, S.; Savage, M.; Varga, Z.M.; Lawrence, C.; Sanders, G.; Walter, R.B.
Title Fluorescent light exposure incites acute and prolonged immune responses in Zebrafish (Danio rerio) skin Type Journal Article
Year 2018 Publication Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP Abbreviated Journal Comp Biochem Physiol C Toxicol Pharmacol
Volume 208 Issue Pages 87-95
Keywords Animals
Abstract Artificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there exists a paucity of data regarding the molecular genetic effects of artificial light exposure. Previous studies showed that one of the commonly used fluorescent light source (FL; 4100K or “cool white”) can affect signaling pathways related to maintenance of circadian rhythm, cell cycle progression, chromosome segregation, and DNA repair/recombination in the skin of male Xiphophorus maculatus. These observations raise questions concerning the kinetics of the FL induced gene expression response, and which biological functions become modulated at various times after light exposure. To address these questions, we exposed zebrafish to 4100K FL and utilized RNASeq to assess gene expression changes in skin at various times (1 to 12h) after FL exposure. We found 4100K FL incites a robust early (1-2h) transcriptional response, followed by a more protracted late response (i.e., 4-12h). The early transcriptional response involves genes associated with cell migration/infiltration and cell proliferation as part of an overall increase in immune function and inflammation. The protracted late transcriptional response occurs within gene sets predicted to maintain and perpetuate the inflammatory response, as well as suppression of lipid, xenobiotic, and melatonin metabolism.
Address Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, 419 Centennial Hall, Texas State University, 601 University Drive, San Marcos, TX 78666, USA. Electronic address: RWalter@txstate.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1532-0456 ISBN Medium
Area Expedition Conference
Notes PMID:28965927 Approved no
Call Number LoNNe @ kyba @ Serial 1740
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Author Van Doren, B.; Horton, K.G.; Dokter, A.M.; Klinck, H.; Elbin, S.B., Farnsworth, A.; Dokter, A.M; Klinck, H.; Elbin, S.B.; Farnsworth, A.
Title High-intensity urban light installation dramatically alters nocturnal bird migration Type Journal Article
Year 2017 Publication Publications of the National Academy of Sciences Abbreviated Journal PNAS
Volume 114 Issue 42 Pages 11175-11180
Keywords Animals; artificial light; nocturnal migration; remote sensing; radar; ornithology; flight calls
Abstract Billions of nocturnally migrating birds move through increasingly photopolluted skies, relying on cues for navigation and orientation that artificial light at night (ALAN) can impair. However, no studies have quantified avian responses to powerful ground-based light sources in urban areas. We studied effects of ALAN on migrating birds by monitoring the beams of the National September 11 Memorial & Museum's “Tribute in Light” in New York, quantifying behavioral responses with radar and acoustic sensors and modeling disorientation and attraction with simulations. This single light source induced significant behavioral alterations in birds, even in good visibility conditions, in this heavily photopolluted environment, and to altitudes up to 4 km. We estimate that the installation influenced ≈1.1 million birds during our study period of 7 d over 7 y. When the installation was illuminated, birds aggregated in high densities, decreased flight speeds, followed circular flight paths, and vocalized frequently. Simulations revealed a high probability of disorientation and subsequent attraction for nearby birds, and bird densities near the installation exceeded magnitudes 20 times greater than surrounding baseline densities during each year’s observations. However, behavioral disruptions disappeared when lights were extinguished, suggesting that selective removal of light during nights with substantial bird migration is a viable strategy for minimizing potentially fatal interactions among ALAN, structures, and birds. Our results also highlight the value of additional studies describing behavioral patterns of nocturnally migrating birds in powerful lights in urban areas as well as conservation implications for such lighting installations.
Address Information Science Program, Cornell Lab of Ornithology, Ithaca, NY 14850 USA; af27{at}cornell.edu
Corporate Author Thesis
Publisher PNAS Place of Publication Editor
Language English Summary Language English Original Title (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1091-6490 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 1741
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