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Author Verma, A.K.; Singh, S.; Rizvi, S.I.
Title Age-dependent altered redox homeostasis in the chronodisrupted rat model and moderation by melatonin administration Type Journal Article
Year 2020 Publication (up) Chronobiology International Abbreviated Journal Chronobiol Int
Volume in press Issue Pages
Keywords Animals; Aging; artificial light-at-night; circadian disruption; melatonin; oxidative stress
Abstract Circadian disruption or chronodisruption (CD) occurs when day-night cycles and other internal rhythms are not adjusted to environmental light-dark regimens and are unable to synchronize among each other. Artificial light-induced oxidative stress is a major concern as the circadian physiology of the cell is chronically altered due to suppression of the time-keeping hormone, melatonin. The relationship between age-related impaired redox status and disrupted circadian rhythms is still not fully understood. The present study evaluated the effect of artificial light at night (ALAN) with respect to aging and role of melatonin supplementation. This study was conducted on young (3 months) and old (24 months) male Wistar rats subdivided into four groups control (C), melatonin treated (MLT), artificial light at night (ALAN), and ALAN+MLT group. Pronounced changes were observed in the old compared to the young rats. Reactive oxygen species (ROS), malondialdehyde (MDA), plasma membrane redox system (PMRS), protein carbonyl (PCO), and sialic acid (SA) were significantly (p </= 0.05) increased, while ferric reducing ability of plasma (FRAP) and reduced glutathione (GSH) were significantly (p </= 0.05) suppressed in light-exposed young and old animals compared to their age-matched controls. Advanced oxidation protein products (AOPP) increased non-significantly in young rats of the ALAN group; however, significant (p </= 0.05) changes were observed in the old rats of the ALAN group compared to their respective controls. Advanced glycation end products (AGEs) increased and acetylcholinesterase (AChE) activity decreased, significantly (p </= 0.05) in young animals of the ALAN group, while nonsignificant changes of both parameters were recorded in the old animals of the ALAN groups compared with their age-matched controls. Melatonin supplementation resulted in maintenance of the normal redox homeostasis in both young and old animal groups. Our study suggests that aged rats are more susceptible to altered photoperiod as their circadian redox homeostasis is under stress subsequent to ALAN. Melatonin supplementation could be a promising means of alleviating age-related circadian disturbances, especially in light-polluted areas.
Address Department of Biochemistry, University of Allahabad , Allahabad, India
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-0528 ISBN Medium
Area Expedition Conference
Notes PMID:32731777 Approved no
Call Number GFZ @ kyba @ Serial 3067
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Author Liu, Y.; Zhang, X.; Pan, X.; Ma, X.; Tang, M.
Title The spatial integration and coordinated industrial development of urban agglomerations in the Yangtze River Economic Belt, China Type Journal Article
Year 2020 Publication (up) Cities Abbreviated Journal Cities
Volume 104 Issue Pages 102801
Keywords Remote Sensing
Abstract Urban agglomeration is the engine of national development and regional prosperity. Although extensive work has investigated issues related to this new form of spatial governance, few studies have directly illustrated the spatial integration of urban agglomeration and its relationship with industrial development. This paper employs nighttime light data and industrial enterprise datasets to investigate the spatial integration and industrial development in the Yangtze River Economic Belt (YREB) of China for 1995–2015. We here illustrate the significant relationship between the spatial integration of urban agglomerations and the characteristics of industrial development. In the process of spatial integration, urban form, intercity relation and their evolution show clear regional differences. Because of the differences in socio-economic and geographical characteristics, urban systems are more advanced and closely related in developed areas. A significant negative (positive) spatial correlation between industrial specialization (diversification) and urban form is supported by using bivariate Moran's I, and spatial clustering patterns are clearly different across the three urban agglomerations. A panel regression reveals that intercity relations are significantly associated with the characteristics of industrial development. Higher levels of industrial diversification and competition are associated with weaker intercity relations, while industrial structures similarities are reversed. These findings could be used to formulate reasonable policies and plans and to support future regional spatial integration and coordinated development.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0264-2751 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2986
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Author Alzahrani, H.S.; Khuu, S.K.; Roy, M.
Title Modelling the effect of commercially available blue-blocking lenses on visual and non-visual functions Type Journal Article
Year 2019 Publication (up) Clinical & Experimental Optometry Abbreviated Journal Clin Exp Optom
Volume in press Issue Pages cxo.12959
Keywords Human Health; blue-blocking lenses; non-visual functions; transmittance; visual functions
Abstract BACKGROUND: Blue-blocking lenses (BBLs) are marketed as providing retinal protection from acute and cumulative exposure to blue light over time. The selective reduction in visible wavelengths transmitted through BBLs is known to influence the photosensitivity of retinal photoreceptors, which affects both visual and non-visual functions. This study measured the spectral transmittance of BBLs and evaluated their effect on blue perception, scotopic vision, circadian rhythm, and protection from photochemical retinal damage. METHODS: Seven different types of BBLs from six manufacturers and untinted control lenses with three different powers (+2.00 D, -2.00 D and Plano) were evaluated. The whiteness index of BBLs used in this study was calculated using Commission International de l'Eclairage (CIE) Standard Illuminates D65, and CIE 1964 Standard with a 2 degrees Observer. The protective qualities of BBLs and their effect on blue perception, scotopic vision, and circadian rhythm were evaluated based on their spectral transmittance, which was measured with a Cary 5,000 UV-Vis-NIR spectrophotometer. RESULTS: BBLs were found to reduce blue light (400-500 nm) by 6-43 per cent, providing significant protection from photochemical retinal damage compared to control lenses (p </= 0.05). All BBLs were capable of reducing the perception of blue colours, scotopic sensitivities and circadian sensitivities by 5-36 per cent, 5-24 per cent, and 4-27 per cent, respectively depending on the brand and power of the lens. CONCLUSION: BBLs can provide some protection to the human eye from photochemical retinal damage by reducing a portion of blue light that may affect visual and non-visual performances, such as those critical to scotopic vision, blue perception, and circadian rhythm.
Address School of Optometry and Vision Science, The University of New South Wales, Sydney, Australia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0816-4622 ISBN Medium
Area Expedition Conference
Notes PMID:31441122 Approved no
Call Number GFZ @ kyba @ Serial 2654
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Author Lowden, A.; Lemos, N.; Gonçalves, B.; Öztürk, G.; Louzada, F.; Pedrazzoli, M.; Moreno, C.
Title Delayed Sleep in Winter Related to Natural Daylight Exposure among Arctic Day Workers Type Journal Article
Year 2018 Publication (up) Clocks & Sleep Abbreviated Journal Clocks & Sleep
Volume 1 Issue 1 Pages 105-116
Keywords Human Health
Abstract Natural daylight exposures in arctic regions vary substantially across seasons. Negative consequences have been observed in self-reports of sleep and daytime functions during the winter but have rarely been studied in detail. The focus of the present study set out to investigate sleep seasonality among indoor workers using objective and subjective measures. Sleep seasonality among daytime office workers (n = 32) in Kiruna (Sweden, 67.86° N, 20.23° E) was studied by comparing the same group of workers in a winter and summer week, including work and days off at the weekend, using actigraphs (motion loggers) and subjective ratings of alertness and mood. Actigraph analyses showed delayed sleep onset of 39 min in winter compared to the corresponding summer week (p < 0.0001) and shorter weekly sleep duration by 12 min (p = 0.0154). A delay of mid-sleep was present in winter at workdays (25 min, p < 0.0001) and more strongly delayed during days off (46 min, p < 0.0001). Sleepiness levels were higher in winter compared to summer (p < 0.05). Increased morning light exposure was associated with earlier mid-sleep (p < 0.001), while increased evening light exposure was associated with delay (p < 0.01). This study confirms earlier work that suggests that lack of natural daylight delays the sleep/wake cycle in a group of indoor workers, despite having access to electric lighting. Photic stimuli resulted in a general advanced sleep/wake rhythm during summer and increased alertness levels.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2624-5175 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2137
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Author Prayag, A.; Münch, M.; Aeschbach, D.; Chellappa, S.; Gronfier, C.
Title Light Modulation of Human Clocks, Wake, and Sleep Type Journal Article
Year 2019 Publication (up) Clocks & Sleep Abbreviated Journal Clocks & Sleep
Volume 1 Issue 1 Pages 193-208
Keywords Human Health; Review
Abstract Light, through its non-imaging forming effects, plays a dominant role on a myriad of physiological functions, including the human sleep–wake cycle. The non-image forming effects of light heavily rely on specific properties such as intensity, duration, timing, pattern, and wavelengths. Here, we address how specific properties of light influence sleep and wakefulness in humans through acute effects, e.g., on alertness, and/or effects on the circadian timing system. Of critical relevance, we discuss how different characteristics of light exposure across the 24-h day can lead to changes in sleep–wake timing, sleep propensity, sleep architecture, and sleep and wake electroencephalogram (EEG) power spectra. Ultimately, knowledge on how light affects sleep and wakefulness can improve light settings at home and at the workplace to improve health and well-being and optimize treatments of chronobiological disorders.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2624-5175 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2266
Permanent link to this record