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Author Walker, W.H. 2nd; Melendez-Fernandez, O.H.; Nelson, R.J.
Title Prior exposure to dim light at night impairs dermal wound healing in female C57BL/6 mice Type Journal Article
Year 2019 Publication (up) Archives of Dermatological Research Abbreviated Journal Arch Dermatol Res
Volume 311 Issue 7 Pages 573-576
Keywords Animals; mouse models; Skin; Human Health
Abstract Artificial light at night (LAN) is a pervasive phenomenon in today's society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effects of dim LAN (DLAN) on wound healing. Female C57BL/6 mice were housed for 3 weeks in DLAN or LD conditions prior to wounding. Following wounding, mice were maintained in either their previous light conditions or switched to the opposite lighting conditions for 3 weeks. DLAN prior to wounding impaired healing; specifically, mice in DLAN/DLAN had significantly larger wounds on day 8. Additionally, mice in DLAN/LD had significantly larger wounds on days 5, 7, 8, and 9, and increased average time to closure. These data demonstrate a potential harmful effect of DLAN on wound healing that should be considered and may represent a target for therapeutic intervention.
Address Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA
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ISSN 0340-3696 ISBN Medium
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Notes PMID:31144020 Approved no
Call Number GFZ @ kyba @ Serial 2515
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Author Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L.
Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
Year 2019 Publication (up) Archives of Toxicology Abbreviated Journal Arch Toxicol
Volume 93 Issue 5 Pages 1401-1415
Keywords Vision; age-related macular degeneration; Eye; Eye Diseases; blue light
Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.
Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar
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Language English Summary Language Original Title
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Series Volume Series Issue Edition
ISSN 0340-5761 ISBN Medium
Area Expedition Conference
Notes PMID:30778631 Approved no
Call Number GFZ @ kyba @ Serial 2229
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Author Jong, M. de; Eertwegh, L. van den; Beskers, R.E.; Vries, P.P. de; Spoelstra, K.; Visser, M.E.
Title Timing of Avian Breeding in an Urbanised World Type Journal Article
Year 2018 Publication (up) Ardea Abbreviated Journal Ardea
Volume 106 Issue 1 Pages 31-38
Keywords Animals
Abstract A large part of the world is urbanised, and the process of urbanisation is ongoing. This causes dramatic alterations of species' habitat such as increased night light, sound levels and temperature, along with direct disturbance by human activity. We used eight years of citizen science data from ten common bird species breeding in nest boxes throughout The Netherlands to study the relationship between urbanisation and a key life history trait, timing of breeding. We used nightly light levels in the form of sky brightness and light emission as a proxy for urbanisation as the dramatic change of the night-time environment is a prominent effect of urbanisation. We expected birds to lay earlier in areas with more light at night, i.e. in more urbanised areas. We found, however, no relationship between light levels and seasonal timing in the ten species studied. A limitation of our study is that there was only limited data for the areas that were urbanised most (e.g. inside cities). Most nest box study areas are located in areas with a limited level of urbanisation, and hence with relatively low light levels of light at night. The lack of data on breeding birds in more urbanised environments, which is a rapidly expanding habitat for an increasing number of species worldwide, should be the focus of attention and citizen science would be highly suitable to also provide data for such areas.
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ISSN 0373-2266 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 1893
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Author Barros, R.; Medrano, F.; Norambuena, H.V.; Peredo, R.; Silva, R.; de Groote, F.; Schmitt, F.
Title Breeding Phenology, Distribution and Conservation Status of Markham's Storm-Petrel Oceanodroma markhami in the Atacama Desert Type Journal Article
Year 2019 Publication (up) Ardea Abbreviated Journal Ardea
Volume 107 Issue 1 Pages 75
Keywords Animals
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ISSN 0373-2266 ISBN Medium
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Notes Approved no
Call Number GFZ @ kyba @ Serial 2434
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Author Marín-Gómez, O.H, & MacGregor-Fors, I.
Title How Early Do Birds Start Chirping? Dawn Chorus Onset and Peak Times in a Neotropical City Type Journal Article
Year 2019 Publication (up) Ardeola Abbreviated Journal
Volume 66 Issue 2 Pages 327-341
Keywords Animals
Abstract Urbanisation poses important challenges for animal communication. Avian dawn choruses are a prominent component of urban soundscapes and have received attention in recent urban ecology studies. Current evidence based on comparisons of urban and non-urban sites suggest that urbanisation is associated with earlier dawn chorus singing activity. However, this phenomenon remains mainly unexplored in tropical cities. We here assessed dawn chorus onset and peak times in two contrasting conditions of the urbanisation intensity gradient (i.e., intra-urban and peri-urban forested areas) of a Neotropical city, Xalapa in Mexico, assessing relationships with noise at sunrise and artificial light at night. We found no differences in dawn chorus onset or singing peak times when contrasting intra- and peri-urban areas. However, we found non-significant trends for earlier chorus onsets and peak times with increasing noise levels. Our results show no relationship between artificial light at night and dawn chorus timing, adding evidence to recent studies showing that light pollution does not seem to be determinant in the dawn choruses of tropical birds. Further research is needed to include a wider array of urbanisation conditions and drivers of the singing routines of urban tropical birds. —Marín-Gómez, O.H. & MacGregor-Fors, I. (2019). How early do birds start chirping? Dawn chorus onset and peak times in a Neotropical city.
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Notes Approved no
Call Number IDA @ intern @ Serial 2553
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