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Author Namgyal, D.; Chandan, K.; Sultan, A.; Aftab, M.; Ali, S.; Mehta, R.; El-Serehy, H.A.; Al-Misned, F.A.; Sarwat, M.
Title Dim Light at Night Induced Neurodegeneration and Ameliorative Effect of Curcumin Type Journal Article
Year 2020 Publication Cells Abbreviated Journal Cells
Volume 9 Issue 9 Pages
Keywords Human health; *brain-derived neurotrophic factor; *curcumin; *diurnal rhythm; *lipid peroxidation; *microRNA; *neurodegeneration; *neurogenesis; *neuroprotection; *oxidative stress
Abstract It is a well-known fact that following a proper routine light/dark or diurnal rhythm controls almost all biological processes. With the introduction of modern lighting and artificial illumination systems, continuous exposure to light at night may lead to the disruption of diurnal rhythm. However, the effect of light during the night on brain anatomy, physiology, and human body functions is less explored and poorly understood. In this study, we have evaluated the effect of exposure to dim light (5 lux) at night (dLAN) on Swiss Albino mice over a duration of three consecutive weeks. Results have revealed that exposure to dLAN led to an impairment of cognitive and non-cognitive behaviour, oxidative stress-mediated elevation of lipid peroxidation, and reduction of superoxide dismutase and catalase activity. It also led to the downregulation of hippocampal proteins (BDNF, Synapsin II and DCX) at both protein and mRNA level. Additionally, there was downregulation of CREB and SIRT1 mRNAs and neurodegeneration-associated miRNA21a-5p and miRNA34a-5p. The pyramidal and cortical neurons started showing pyknotic and chromatolysis characteristics. However, a dose of curcumin administered to the mice positively modulated these parameters in our experimental animals. We proposed the modulatory role of curcumin in addressing the deleterious effects of dLAN.
Address Amity Institute of Pharmacy, Amity University, Noida UP 201303, India; dhonamdhonam ( at ) gmail.com
Corporate Author Thesis
Publisher (down) MDPI Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2073-4409 ISBN Medium
Area Expedition Conference
Notes PMID:32933226; PMCID:PMC7565558 Approved no
Call Number IDA @ john @ Serial 3385
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Author Anand, A.; Kim, D.-H.
Title Pandemic Induced Changes in Economic Activity around African Protected Areas Captured through Night-Time Light Data Type Journal Article
Year 2021 Publication Remote Sensing Abbreviated Journal Remote Sensing
Volume 13 Issue 2 Pages 314
Keywords Economics; VIIRS; night-time lights; COVID-19; pandemic; protected areas; wildlife tourism
Abstract The importance of tourism for development is widely recognized. Travel restrictions imposed to contain the spread of COVID-19 have brought tourism to a halt. Tourism is one of the key sectors driving change in Africa and is based exclusively on natural assets, with wildlife being the main attraction. Economic activities, therefore, are clustered around conservation and protected areas. We used night-time light data as a proxy measure for economic activity to assess change due to the pandemic. Our analysis shows that overall, 75 percent of the 8427 protected areas saw a decrease in light intensity in varying degrees in all countries and across IUCN protected area categories, including in popular protected area destinations, indicating a reduction in tourism-related economic activities. As countries discuss COVID-19 recovery, the methods using spatially explicit data illustrated in this paper can assess the extent of change, inform decision-making, and prioritize recovery efforts.
Address Independent Evaluation Office, Global Environment Facility, Washington, DC 20006, USA; aanand2 ( at ) thegef.org
Corporate Author Thesis
Publisher (down) MDPI Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2072-4292 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 3390
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Author Okuliarova, M.; Rumanova, V.S.; Stebelova, K.; Zeman, M.
Title Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism Type Journal Article
Year 2020 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci
Volume 21 Issue 18 Pages
Keywords Human health; chronodisruption; circadian clocks; fatty acids; glucose; insulin; leptin; lipogenesis; liver; nuclear receptors; steatosis
Abstract Dim light at night (dLAN) is associated with metabolic risk but the specific effects on lipid metabolism have only been evaluated to a limited extent. Therefore, to explore whether dLAN can compromise lipid metabolic homeostasis in healthy individuals, we exposed Wistar rats to dLAN (~2 lx) for 2 and 5 weeks and analyzed the main lipogenic pathways in the liver and epididymal fat pad, including the control mechanisms at the hormonal and molecular level. We found that dLAN promoted hepatic triacylglycerol accumulation, upregulated hepatic genes involved in de novo synthesis of fatty acids, and elevated glucose and fatty acid uptake. These observations were paralleled with suppressed fatty acid synthesis in the adipose tissue and altered plasma adipokine levels, indicating disturbed adipocyte metabolic function with a potential negative impact on liver metabolism. Moreover, dLAN-exposed rats displayed an elevated expression of two peroxisome proliferator-activated receptor family members (Pparalpha and Ppargamma) in the liver and adipose tissue, suggesting the deregulation of important metabolic transcription factors. Together, our results demonstrate that an impaired balance of lipid biosynthetic pathways caused by dLAN can increase lipid storage in the liver, thereby accounting for a potential linking mechanism between dLAN and metabolic diseases.
Address Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia; monika.okuliarova ( at ) uniba.sk
Corporate Author Thesis
Publisher (down) MDPI Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1422-0067 ISBN Medium
Area Expedition Conference
Notes PMID:32967195; PMCID:PMC7555372 Approved no
Call Number IDA @ john @ Serial 3395
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Author Zissis, G.
Title Sustainable Lighting and Light Pollution: A Critical Issue for the Present Generation, a Challenge to the Future Type Journal Article
Year 2020 Publication Sustainability Abbreviated Journal Sustainability
Volume 12 Issue 11 Pages 4552
Keywords Society; light pollution measurement and modelling; light pollution impact on fauna and flora; light pollution impact on human health; policies to prevent/limit light pollution and territorial management; best practices for street lighting with low impact on light pollution; smart lighting and light pollution
Abstract Human beings’ poor night vision and primitive fear of the dark are reflected in an imperative need to use artificial light to illuminate their environment. Outdoor illumination undoubtedly contributes to the enhancement of practical opportunities for social and economic developments. Considered as a necessity, a means of security, and an attraction or valorization, city lighting growth has been literally exponential in the last half century. Beyond the financial and energy resources that it absorbs, the artificial lighting of urban spaces overflows its objective by polluting our nights to the point that, in our modern megacities, the stars disappear. Apart from the fact that stars are no longer visible, the scientific community is increasingly interested in the direct and indirect impacts of artificial lighting on biodiversity. In parallel, some studies have shown recently that stray light may have direct or indirect effects on human health and mood. The scope of this Special Issue, dedicated to the memory of Prof. Abraham Haim and Dr. Thomas Posch, is to put together a series of high-level papers treating light pollution in a holistic manner that goes from technological advances to policies, passing through impacts on biotopes and human health. Beyond its evident scientific interest, this Special Issue is also contributing to awareness raising, aimed at decision- and policy-makers.
Address LAPLACE UMR 5213 CNRS-INPT-UT3, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse, CEDEX 9, France; georges.zissis ( at ) laplace.univ-tlse.fr
Corporate Author Thesis
Publisher (down) MDPI Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2071-1050 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ john @ Serial 3398
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Author Zhang, S.; Wang, Y.; Zhu, Y.; Li, X.; Song, Y.; Yuan, J.
Title Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort Type Journal Article
Year 2020 Publication International Journal of Environmental Research and Public Health Abbreviated Journal Int J Environ Res Public Health
Volume 17 Issue 23 Pages
Keywords Human health; Adult; Asian Continental Ancestry Group; China/epidemiology; Circadian Rhythm; Female; *Glomerular Filtration Rate; Humans; Male; Middle Aged; Risk Factors; *Shift Work Schedule/adverse effects; Uric Acid; Work Schedule Tolerance; Young Adult; *light at night; *night shift work; *renal function
Abstract The misalignment between the circadian clock and behavioral cycles has been implicated in pathogenesis of many diseases. The main purpose of this study is to examine the association between rotating night shift work, exposure to light at night, and glomerular filtration rate among steelworkers in north China. A total of 6869 steelworkers, aged 22 to 60 years, were included in this study. Multivariable logistic regression was used to examine the association between night shift work, the brightness of bedroom ambient light at night (LAN), and estimated glomerular filtration rate (eGFR), with adjustment for potential confounders. Mediation analysis was performed to examine the mediation effect of potential mediators on the association of duration of night shifts and eGFR. Long duration of night shift work (>/=29 years) had elevated odds of decreased eGFR (</=89 mL/min/1.73 m(2)) (odds ratio (OR), 1.37, 95% confidence interval (CI) 1.09-1.73) compared with day work after adjustment for potential confounders. The association between duration of night shifts and eGFR (continuous) was partially modified by diastolic blood pressure (average causal mediation effect (ACME), -0.077, 95% CI -0.134 to -0.030, p < 0.001). No significant associations were observed among the different brightness of bedroom ambient light levels: middle level (OR, 0.90, 95% CI 0.77-1.05), lightest level (OR, 0.94, 95% CI 0.75-1.18), and decreased eGFR compared with the darkest level. Long-term night-shift work, rather than the brightness of bedroom ambient LAN, is associated with early stage of renal dysfunction in steelworkers, and blood pressure may mediate the relationship between night shift work and decreased eGFR.
Address Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China
Corporate Author Thesis
Publisher (down) MDPI Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1660-4601 ISBN Medium
Area Expedition Conference
Notes PMID:33291553; PMCID:PMC7730862 Approved no
Call Number IDA @ john @ Serial 3399
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