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Author Letzkus, L.
Title Red Light at Night: A Feasibility Study in Hospitalized Patients Type Journal Article
Year 2020 Publication MEDSURG Nursing Abbreviated Journal
Volume 29 Issue 1 Pages 38-42
Keywords Human Health
Abstract Light can be a noxious stimulus during hospitalization. The study evaluated use of a red night-light intervention for hospitalized adults. The red light was found to be a feasible intervention and well received by participants.
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Call Number GFZ @ kyba @ Serial (down) 2831
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Author Pan, Y.-R.; Song, J.-Y.; Fan, B.; Wang, Y.; Che, L.; Zhang, S.-M.; Chang, Y.-X.; He, C.; Li, G.-Y.
Title mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors Type Journal Article
Year 2020 Publication Cell Communication and Signaling : CCS Abbreviated Journal Cell Commun Signal
Volume 18 Issue 1 Pages 27
Keywords Health; Aif; Parp-1; Parthanatos; Retinal neuroprotection; Sirt1; mTOR
Abstract BACKGROUND: Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cells remains unclear. The mammalian/mechanistic target of rapamycin (mTOR) and Poly (ADP-ribose) polymerase-1 (PARP-1) have become the primary targets for treating many neurodegenerative disorders. The aim of this study was to elucidate the mechanisms underlying light-induced photoreceptor cell death and whether the neuroprotective effects of mTOR and PARP-1 inhibition against death are mediated through apoptosis-inducing factor (AIF). METHODS: Propidium iodide (PI)/Hoechst staining, lentiviral-mediated short hairpin RNA (shRNA), Western blot analysis, cellular fraction separation, plasmid transient transfection, laser confocal microscopy, a mice model, electroretinography (ERG), and hematoxylin-eosin (H & E) staining were employed to explore the mechanisms by which rapamycin/3-Aminobenzamide (3AB) exert neuroprotective effects of mTOR/PARP-1 inhibition in light-injured retinas. RESULTS: A parthanatos-like death mechanism was evaluated in light-injured 661 W cells that are an immortalized photoreceptor-like cell line that exhibit cellular and biochemical feature characteristics of cone photoreceptor cells. The death process featured over-activation of PARP-1 and AIF nuclear translocation. Either PARP-1 or AIF knockdown played a significantly protective role for light-damaged photoreceptors. More importantly, crosstalk was observed between mTOR and PARP-1 signaling and mTOR could have regulated parthanatos via the intermediate factor sirtuin 1 (SIRT1). The parthanatos-like injury was also verified in vivo, wherein either PARP-1 or mTOR inhibition provided significant neuroprotection against light-induced injury, which is evinced by both structural and functional retinal analysis. Overall, these results elucidate the mTOR-regulated parthanatos death mechanism in light-injured photoreceptors/retinas and may facilitate the development of novel neuroprotective therapies for retinal degeneration diseases. CONCLUSIONS: Our results demonstrate that inhibition of the mTOR/PARP-1 axis exerts protective effects on photoreceptors against visible-light-induced parthanatos. These protective effects are conducted by regulating the downstream factors of AIF, while mTOR possibly interacts with PARP-1 via SIRT1 to regulate parthanatos. Video Abstract Schematic diagram of mTOR interacting with PARP-1 to regulate visible light-induced parthanatos. Increased ROS caused by light exposure penetrates the nuclear membrane and causes nuclear DNA strand breaks. PARP-1 detects DNA breaks and synthesizes PAR polymers to initiate the DNA repair system that consumes a large amount of cellular NAD+. Over-production of PAR polymers prompts the release of AIF from the mitochondria and translocation to the nucleus, which leads to parthanatos. Activated mTOR may interact with PARP-1 via SIRT1 to regulate visible light-induced parthanatos.
Address Department of Ophthalmology, Second Hospital of JiLin University, No.218 Zi-Qiang St, ChangChun, 130041, China. liguangyu@aliyun.com
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ISSN 1478-811X ISBN Medium
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Notes PMID:32066462 Approved no
Call Number GFZ @ kyba @ Serial (down) 2830
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Author Yue, F.; Xia, K.; Wei, L.; Xing, L.; Wu, S.; Shi, Y.; Man, L.S.; Shui, G.; Xiang, X.; Russell, R.; Zhang, D.
Title Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats Type Journal Article
Year 2020 Publication Journal of Gastroenterology and Hepatology Abbreviated Journal J Gastroenterol Hepatol
Volume in press Issue Pages
Keywords Animals; apoptosis; ceramide; light pollution; non-alcoholic fatty liver disease; sphingolipids
Abstract BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern worldwide. With the progression of urbanization, light pollution is becoming an inevitable risk factor for NAFLD. However, the role of light pollution on NAFLD is insufficiently understood, and the underlying mechanism remains unclear. The present study explored effects of constant light exposure on NAFLD and elucidated its related mechanisms. METHODS: Thirty-two male SD rats were divided into 4 groups (n=8 each): 1) rats on a normal diet exposed to standard light-dark cycle (ND-LD); 2) rats on a normal diet exposed to constant light (ND-LL); 3) rats on a high fat diet exposed to standard light-dark cycle (HFD-LD); 4) and rats on a high fat diet exposed to constant light (HFD-LL). After 12 weeks treatment, rats were sacrificed and pathophysiological assessments were performed. Targeted lipidomics was used to measure sphingolipids, including ceramides, glucosylceramides and lactosylceramides, sphingomyelins and sphingosine-1-phosphates in plasma and liver tissues. RESULTS: In normal chow rats, constant light exposure led to glucose abnormalities and dyslipidemia. In high-fat fed rats, constant light exposure exacerbated glucose abnormalities, dyslipidemia, insulin resistance, inflammation and aggravated steatohepatitis. Compared to HFD-LD rats, HFD-LL had decreased plasma sphingosine-1-phosphate and elevated liver concentrations of total ceramides and specific ceramide species (ceramide d18:0/24:0, ceramide d18:1/22:0, ceramide d18:1/24:0 and ceramide d18:1/24:1), and which were associated with increased hepatocyte apoptosis. CONCLUSIONS: Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats.
Address Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China
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ISSN 0815-9319 ISBN Medium
Area Expedition Conference
Notes PMID:32027419 Approved no
Call Number GFZ @ kyba @ Serial (down) 2829
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Author Zhou, H.; Liu, L.; Lan, M.; Yang, B.; Wang, Z.
Title Assessing the Impact of Nightlight Gradients on Street Robbery and Burglary in Cincinnati of Ohio State, USA Type Journal Article
Year 2019 Publication Remote Sensing Abbreviated Journal Remote Sensing
Volume 11 Issue 17 Pages 1958
Keywords Remote Sensing; Public Safety; Crime
Abstract Previous research has recognized the importance of edges to crime. Various scholars have explored how one specific type of edges such as physical edges or social edges affect crime, but rarely investigated the importance of the composite edge effect. To address this gap, this study introduces nightlight data from the Visible Infrared Imaging Radiometer Suite sensor on the Suomi National Polar-orbiting Partnership Satellite (NPP-VIIRS) to measure composite edges. This study defines edges as nightlight gradients—the maximum change of nightlight from a pixel to its neighbors. Using nightlight gradients and other control variables at the tract level, this study applies negative binomial regression models to investigate the effects of edges on the street robbery rate and the burglary rate in Cincinnati. The Akaike Information Criterion (AIC) of models show that nightlight gradients improve the fitness of models of street robbery and burglary. Also, nightlight gradients make a positive impact on the street robbery rate whilst a negative impact on the burglary rate, both of which are statistically significant under the alpha level of 0.05. The different impacts on these two types of crimes may be explained by the nature of crimes and the in-situ characteristics, including nightlight.
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ISSN 2072-4292 ISBN Medium
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Notes Approved no
Call Number GFZ @ kyba @ Serial (down) 2828
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Author Kyba, C.C.M.; Conrad, J.; Shatwell, T.
Title Lunar illuminated fraction is a poor proxy for moonlight exposure Type Journal Article
Year 2020 Publication Nature Ecology & Evolution Abbreviated Journal Nat Ecol Evol
Volume 4 Issue Pages 318-319
Keywords Animals; Moonlight; Commentary
Abstract San-Jose et al. recently demonstrated that the colouration of barn owls impacts their hunting success under moonlit conditions, and therefore affects their reproductive success1. They found that near full-moon conditions, the youngest nestlings with white fathers were fed more and were likelier to survive than those with redder fathers. While the study is interesting, the percentage of the Moon that is illuminated (lunar illuminated fraction) is unfortunately a poor proxy for moonlight exposure. We suggest that lunar illluminated fraction should, in general, never be used in biological studies, as alternative variables such as horizontal illuminance better represent moonlight exposure, and therefore offer a greater chance of detecting the effects of moonlight. Here, we provide a brief explanation of how moonlight varies with season and time of night, and stress the need for greater collaboration between biologists and astronomers or physicists in such studies in the future.
Address Seenforschung, Helmholtz-Zentrum fur Umweltforschung-UFZ, Magdeburg, Germany
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Language English Summary Language Original Title
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ISSN 2397-334X ISBN Medium
Area Expedition Conference
Notes PMID:32015523 Approved no
Call Number GFZ @ kyba @ Serial (down) 2827
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