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Author Sharma, A.; Goyal, R.
Title Long-term exposure to constant light induces dementia, oxidative stress and promotes aggregation of sub-pathological Abeta42 in Wistar rats Type Journal Article
Year 2020 Publication Pharmacology, Biochemistry, and Behavior Abbreviated Journal Pharmacol Biochem Behav
Volume in press Issue Pages 172892
Keywords Animals; Amyloid beta; Behavior, fluoxetine, rifampicin; Oxidative stress
Abstract Constant exposure to light is prevalent in modern society where light noise, shift work, and jet lag is common. Constant light exposure disrupts circadian rhythm, induces stress and thus influences memory performance. We subjected adult male Wistar rats to a two-month exposure to constant light (LL), constant dark or normal light-dark cycles. Significant cognitive impairment and oxidative stress were observed in LL rats without a significant elevation in soluble Abeta1-42 levels. Next, we examined whether long-term exposure to constant light may accelerate dementia in a sub-pathological Abeta model of rats. Normal control rats received ACSF, AD rats received 440pmol, and sub-pathological Abeta rats (Abeta(s)) received 220pmol of human Abeta42 peptide in a single unilateral ICV administration. Sub-pathological Abeta rats exposed to constant light (LL+Abeta(s)) show significant memory deficits and oxidative damage, although not significantly different from LL rats. Additionally, constant light promoted aggregation of exogenous Abeta42 in LL+Abeta(s) rats shown by the presence of congophilic plaques. Furthermore, chronic fluoxetine treatment (5mg/kg/day) rescued rats from the behavioral deficits, oxidative damage and amyloid aggregation. Whereas, rifampicin treatment (20mg/kg/day) did not reverse the behavioral deficits or oxidative stress but rescued rats from amyloid plaque formation. It was concluded that constant light for two months induces behavioral deficits, oxidative stress, and accelerates aggregation of sub-pathological concentrations of human-Abeta42 peptides in Wistar rats, which is reversed by daily fluoxetine administration.
Address Neuropharmacology Laboratory, School of Pharmaceutical Sciences, Shoolini University, Solan 173 212, Himachal Pradesh, India. Electronic address: rohitgoyal@shooliniuniversity.com
Corporate Author Thesis
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0091-3057 ISBN Medium
Area Expedition Conference
Notes PMID:32142744 Approved no
Call Number GFZ @ kyba @ Serial (down) 2841
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Author Benito, B.; Guillamón, M.-D.; Martínez-Córdoba, P.-J.
Title Determinants of efficiency improvement in the Spanish public lighting sector Type Journal Article
Year 2020 Publication Utilities Policy Abbreviated Journal Utilities Policy
Volume 64 Issue Pages 101026
Keywords Lighting; Economics
Abstract This research analyzes the factors that can improve the efficiency of public lighting. First, the annual and inter-annual efficiency levels are calculated. Second, the effects of a set of environmental variables on these efficiency levels are checked with a truncated regression model. The results show that public management is more efficient than private or mixed management. Higher tourism, stronger local governments, and more hours of sunlight appear to improve efficiency. Local governments with the highest budgetary revenues and the most urbanized area experience the greatest improvement in efficiency year after year.
Address
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Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0957-1787 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial (down) 2840
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Author Fasciani, I.; Petragnano, F.; Aloisi, G.; Marampon, F.; Rossi, M.; Francesca Coppolino, M.; Rossi, R.; Longoni, B.; Scarselli, M.; Maggio, R.
Title A new threat to dopamine neurons: the downside of artificial light Type Journal Article
Year 2020 Publication Neuroscience Abbreviated Journal Neuroscience
Volume in press Issue Pages in press
Keywords Review; Human Health; Parkinson's disease; artificial light; dopamine neurons; melatonin; opsins; photoactivation
Abstract Growing awareness of adverse impacts of artificial light on human health has led to recognize light pollution as a significant global environmental issue. Despite, a large number of studies in rodent and monkey models of Parkinson's disease have reported that near infrared light has neuroprotective effects on dopaminergic neurons, recent findings have shown that prolonged exposure of rodents and birds to fluorescent artificial light results in an increase of neuromelanin granules in substantia nigra and loss of dopaminergic neurons. The observed detrimental effect seems to be dependent on a direct effect of light on the substantia nigra rather than a secondary effect of the alterations of circadian rhythms. Moreover, inferences from animal models to human studies have shown a positive correlation between the prevalence of Parkinson's disease and light pollution. The present article discusses experimental evidence supporting a potentially deleterious impact of light on dopaminergic neurons and highlights the mechanisms whereby light might damage neuronal tissue. Moreover, it analyses epidemiological evidence that suggests light pollution to be an environmental risk factor for Parkinson's disease.
Address Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address: roberto.maggio@univaq.it
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0306-4522 ISBN Medium
Area Expedition Conference
Notes PMID:32142863 Approved no
Call Number GFZ @ kyba @ Serial (down) 2839
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Author Puschnig, J.; Wallner, S.; Posch, T.
Title Circalunar variations of the night sky brightness – an FFT perspective on the impact of light pollution Type Journal Article
Year 2020 Publication Monthly Notices of the Royal Astronomical Society Abbreviated Journal
Volume 492 Issue 2 Pages 2622-2637
Keywords Skyglow; Moonlight
Abstract Circa-monthly activity conducted by moonlight is observed in many species on Earth. Given the vast amount of artificial light at night (ALAN) that pollutes large areas around the globe, the synchronization to the circalunar cycle is often strongly perturbed. Using 2-yr data from a network of 23 photometers (Sky Quality Meters; SQM) in Austria (latitude ∼48°), we quantify how light pollution impacts the recognition of the circalunar periodicity. We do so via frequency analysis of nightly mean sky brightnesses using Fast Fourier Transforms. A very tight linear relation between the mean zenithal night sky brightness (NSB) given in magSQMarcsec−2 and the amplitude of the circalunar signal is found, indicating that for sites with a mean zenithal NSB brighter than 16.5 magSQMarcsec−2 the lunar rhythm practically vanishes. This finding implies that the circalunar rhythm is still detectable (within the broad bandpass of the SQM) at most places around the globe, but its amplitude against the light polluted sky is strongly reduced. We find that the circalunar contrast in zenith is reduced compared to ALAN-free sites by factors of 19 in the state capital of Linz (∼200 000 inhabitants) and 13 in small towns, e.g. Freistadt and Mattighofen, with less than 10 000 inhabitants. Only two of our sites, both situated in national parks (Bodinggraben and Zöblboden), show natural circalunar amplitudes. At our urban sites, we further detect a strong seasonal signal that is linked to the amplification of anthropogenic skyglow during the winter months due to climatological conditions.
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Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0035-8711 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial (down) 2838
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Author Berge, J.; Geoffroy, M.; Daase, M.; Cottier, F.; Priou, P.; Cohen, J.H.; Johnsen, G.; McKee, D.; Kostakis, I.; Renaud, P.E.; Vogedes, D.; Anderson, P.; Last, K.S.; Gauthier, S.
Title Artificial light during the polar night disrupts Arctic fish and zooplankton behaviour down to 200 m depth Type Journal Article
Year 2020 Publication Communications Biology Abbreviated Journal Commun Biol
Volume 3 Issue 1 Pages article 102
Keywords Animals
Abstract For organisms that remain active in one of the last undisturbed and pristine dark environments on the planet—the Arctic Polar Night—the moon, stars and aurora borealis may provide important cues to guide distribution and behaviours, including predator-prey interactions. With a changing climate and increased human activities in the Arctic, such natural light sources will in many places be masked by the much stronger illumination from artificial light. Here we show that normal working-light from a ship may disrupt fish and zooplankton behaviour down to at least 200 m depth across an area of >0.125 km2 around the ship. Both the quantitative and qualitative nature of the disturbance differed between the examined regions. We conclude that biological surveys in the dark from illuminated ships may introduce biases on biological sampling, bioacoustic surveys, and possibly stock assessments of commercial and non-commercial species.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2399-3642 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial (down) 2837
Permanent link to this record