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Author Touitou, Y.; Reinberg, A.; Touitou, D. url  doi
openurl 
  Title (up) Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption Type Journal Article
  Year 2017 Publication Life Sciences Abbreviated Journal Life Sci  
  Volume 173 Issue Pages 94-106  
  Keywords Human Health; Review  
  Abstract Exposure to Artificial Light At Night (ALAN) results in a disruption of the circadian system, which is deleterious to health. In industrialized countries, 75% of the total workforce is estimated to have been involved in shift work and night work. Epidemiologic studies, mainly of nurses, have revealed an association between sustained night work and a 50-100% higher incidence of breast cancer. The potential and multifactorial mechanisms of the effects include the suppression of melatonin secretion by ALAN, sleep deprivation, and circadian disruption. Shift and/or night work generally decreases the time spent sleeping, and it disrupts the circadian time structure. In the long run, this desynchronization is detrimental to health, as underscored by a large number of epidemiological studies that have uncovered elevated rates of several diseases, including cancer, diabetes, cardiovascular risks, obesity, mood disorders and age-related macular degeneration. It amounts to a public health issue in the light of the very substantial number of individuals involved. The IARC has classified shift work in group 2A of “probable carcinogens to humans” since “they involve a circadian disorganization”. Countermeasures to the effects of ALAN, such as melatonin, bright light, or psychotropic drugs, have been proposed as a means to combat circadian clock disruption and improve adaptation to shift and night work. We review the evidence for the ALAN impacts on health. Furthermore, we highlight the importance of an in-depth mechanistic understanding to combat the detrimental properties of exposure to ALAN and develop strategies of prevention.  
  Address UHSA – Groupe Hospitalier Paul Guiraud, 54, avenue de la Republique, 94806 Villejuif, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0024-3205 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28214594 Approved no  
  Call Number GFZ @ kyba @ Serial 2455  
Permanent link to this record
 

 
Author Esaki, Y.; Obayashi, K.; Saeki, K.; Fujita, K.; Iwata, N.; Kitajima, T. url  doi
openurl 
  Title (up) Association between light exposure at night and manic symptoms in bipolar disorder: cross-sectional analysis of the APPLE cohort Type Journal Article
  Year 2020 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume in press Issue Pages in press  
  Keywords Human Health; Bipolar disorder; circadian rhythm; dark; light at night; manic symptom  
  Abstract Previous studies have found that keeping the room dark at night was associated with a decrease in manic symptoms for patients with bipolar disorder (BD). However, the association between light at night of real-life conditions and manic symptoms is unclear. We investigated the association between bedroom light exposure at night and manic symptoms in BD patients. One-hundred and eighty-four outpatients with BD participated in this cross-sectional study. The average light intensity at night during sleep was evaluated using a portable photometer for seven consecutive nights. Manic symptoms were assessed using the Young Mania Rating Scale (YMRS), and scores >/=5 were treated as a “hypomanic state.” The median (interquartile range) YMRS score was 2.0 (0-5.0), and 52 (28.2%) participants were in a hypomanic state. The prevalence of a hypomanic state was significantly higher in the participants with an average light intensity at night exposure of >/=3 lux than in those with <3 lux (36.7% versus 21.9%; P = .02). In multivariable logistic regression analysis adjusted for BD type, depressive symptoms, sleep duration, and daytime physical activity, the odds ratio (OR) for a hypomanic state was significantly higher for the participants with an average light intensity at night exposure of >/=3 lux than for those with <3 lux (OR: 2.15, 95% confidence interval: 1.09-4.22, P = .02). This association remained significant at the cutoff value of YMRS score >/=6 (OR: 2.51, 95% confidence interval: 1.15-5.46; P = .02). The findings of this study indicate bedroom light exposure at night is significantly associated with manic symptoms in BD patients. Although the results of this cross-sectional investigation do not necessarily imply causality, they may serve to inform beneficial nonpharmacological intervention and personalized treatment of BD patients.  
  Address Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32238002 Approved no  
  Call Number GFZ @ kyba @ Serial 2879  
Permanent link to this record
 

 
Author Esaki, Y.; Obayashi, K.; Saeki, K.; Fujita, K.; Iwata, N.; Kitajima, T. url  doi
openurl 
  Title (up) Association between light exposure at night and manic symptoms in bipolar disorder: cross-sectional analysis of the APPLE cohort Type Journal Article
  Year 2020 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume in press Issue Pages in press  
  Keywords Human Health; Bipolar disorder; circadian rhythm; dark; light at night; manic symptom  
  Abstract Previous studies have found that keeping the room dark at night was associated with a decrease in manic symptoms for patients with bipolar disorder (BD). However, the association between light at night of real-life conditions and manic symptoms is unclear. We investigated the association between bedroom light exposure at night and manic symptoms in BD patients. One-hundred and eighty-four outpatients with BD participated in this cross-sectional study. The average light intensity at night during sleep was evaluated using a portable photometer for seven consecutive nights. Manic symptoms were assessed using the Young Mania Rating Scale (YMRS), and scores >/=5 were treated as a “hypomanic state.” The median (interquartile range) YMRS score was 2.0 (0-5.0), and 52 (28.2%) participants were in a hypomanic state. The prevalence of a hypomanic state was significantly higher in the participants with an average light intensity at night exposure of >/=3 lux than in those with <3 lux (36.7% versus 21.9%; P = .02). In multivariable logistic regression analysis adjusted for BD type, depressive symptoms, sleep duration, and daytime physical activity, the odds ratio (OR) for a hypomanic state was significantly higher for the participants with an average light intensity at night exposure of >/=3 lux than for those with <3 lux (OR: 2.15, 95% confidence interval: 1.09-4.22, P = .02). This association remained significant at the cutoff value of YMRS score >/=6 (OR: 2.51, 95% confidence interval: 1.15-5.46; P = .02). The findings of this study indicate bedroom light exposure at night is significantly associated with manic symptoms in BD patients. Although the results of this cross-sectional investigation do not necessarily imply causality, they may serve to inform beneficial nonpharmacological intervention and personalized treatment of BD patients.  
  Address Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32238002 Approved no  
  Call Number GFZ @ kyba @ Serial 2924  
Permanent link to this record
 

 
Author Garcia-Saenz, A.; Sanchez de Miguel, A.; Espinosa, A.; Costas, L.; Aragones, N.; Tonne, C.; Moreno, V.; Perez-Gomez, B.; Valentin, A.; Pollan, M.; Castano-Vinyal, G.; Aube, M.; Kogevinas, M. url  doi
openurl 
  Title (up) Association between outdoor light-at-night exposure and colorectal cancer in Spain (MCC-Spain study) Type Journal Article
  Year 2020 Publication Epidemiology (Cambridge, Mass.) Abbreviated Journal Epidemiology  
  Volume in press Issue Pages  
  Keywords Human Health; Remote Sensing  
  Abstract BACKGROUND: Night shift work, exposure to artificial light-at-night and particularly blue light spectrum, and the consequent circadian disruption may increase the risk of breast and prostate cancer. Colorectal cancer risk may also be increased among night-shift workers. We investigated the association between exposure to artificial light at night according to light spectrum and colorectal cancer among subjects who had never worked at night in a general population case-control study in Spain. METHODS: We examined information on 661 incident histologically verified colorectal cancer cases and 1322 controls from Barcelona and Madrid, 2007-2013. Outdoor artificial light at night exposure was based on images from the International Space Station (ISS) including data on remotely sensed upward light intensity. We derived adjusted odds ratio (OR) estimates and confidence intervals (CI) for visual light, blue light, and spectral sensitivities of the five human photopigments assigned to participant's geocoded longest residence. RESULTS: : Exposure to blue light spectrum was positively associated with colorectal cancer (OR=1.6; 95%CI: 1.2-2.2; highest vs. lowest tertile). ORs were similar (OR=1.7; 95%CI: 1.3-2.3) when further adjusting for area socioeconomic status, diet patterns, smoking, sleep and family history. We observed no association for outdoor visual light (full spectrum) (OR = 1.0, 95%CI 0.7-1.2; highest vs. lowest tertile). Analysis of the five photopigments gave similar results with increased risks for shorter wavelengths overlapping with the blue spectrum and no association for longer wavelengths. CONCLUSIONS: Outdoor blue light spectrum exposure that is increasingly prevalent in recent years may be associated with colorectal cancer risk.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1044-3983 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32639250 Approved no  
  Call Number GFZ @ kyba @ Serial 3043  
Permanent link to this record
 

 
Author Park, Y.-M.M.; White, A.J.; Jackson, C.L.; Weinberg, C.R.; Sandler, D.P. url  doi
openurl 
  Title (up) Association of Exposure to Artificial Light at Night While Sleeping With Risk of Obesity in Women Type Journal Article
  Year 2019 Publication JAMA Internal Medicine Abbreviated Journal JAMA Intern Med  
  Volume 179 Issue 8 Pages 1061-1071  
  Keywords Human Health; Obesity; Sleep  
  Abstract Importance: Short sleep has been associated with obesity, but to date the association between exposure to artificial light at night (ALAN) while sleeping and obesity is unknown. Objective: To determine whether ALAN exposure while sleeping is associated with the prevalence and risk of obesity. Design, Setting, and Participants: This baseline and prospective analysis included women aged 35 to 74 years enrolled in the Sister Study in all 50 US states and Puerto Rico from July 2003 through March 2009. Follow-up was completed on August 14, 2015. A total of 43722 women with no history of cancer or cardiovascular disease who were not shift workers, daytime sleepers, or pregnant at baseline were included in the analysis. Data were analyzed from September 1, 2017, through December 31, 2018. Exposures: Artificial light at night while sleeping reported at enrollment, categorized as no light, small nightlight in the room, light outside the room, and light or television in the room. Main Outcomes and Measures: Prevalent obesity at baseline was based on measured general obesity (body mass index [BMI] >/=30.0) and central obesity (waist circumference [WC] >/=88 cm, waist-to-hip ratio [WHR] >/=0.85, or waist-to-height ratio [WHtR]>/=0.5). To evaluate incident overweight and obesity, self-reported BMI at enrollment was compared with self-reported BMI at follow-up (mean [SD] follow-up, 5.7 [1.0] years). Generalized log-linear models with robust error variance were used to estimate multivariable-adjusted prevalence ratios (PRs) and relative risks (RRs) with 95% CIs for prevalent and incident obesity. Results: Among the population of 43 722 women (mean [SD] age, 55.4 [8.9] years), having any ALAN exposure while sleeping was positively associated with a higher prevalence of obesity at baseline, as measured using BMI (PR, 1.03; 95% CI, 1.02-1.03), WC (PR, 1.12; 95% CI, 1.09-1.16), WHR (PR, 1.04; 95% CI, 1.00-1.08), and WHtR (PR, 1.07; 95% CI, 1.04-1.09), after adjusting for confounding factors, with P < .001 for trend for each measure. Having any ALAN exposure while sleeping was also associated with incident obesity (RR, 1.19; 95% CI, 1.06-1.34). Compared with no ALAN, sleeping with a television or a light on in the room was associated with gaining 5 kg or more (RR, 1.17; 95% CI, 1.08-1.27; P < .001 for trend), a BMI increase of 10% or more (RR, 1.13; 95% CI, 1.02-1.26; P = .04 for trend), incident overweight (RR, 1.22; 95% CI,1.06-1.40; P = .03 for trend), and incident obesity (RR, 1.33; 95% CI, 1.13-1.57; P < .001 for trend). Results were supported by sensitivity analyses and additional multivariable analyses including potential mediators such as sleep duration and quality, diet, and physical activity. Conclusions and Relevance: These results suggest that exposure to ALAN while sleeping may be a risk factor for weight gain and development of overweight or obesity. Further prospective and interventional studies could help elucidate this association and clarify whether lowering exposure to ALAN while sleeping can promote obesity prevention.  
  Address Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2168-6106 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31180469 Approved no  
  Call Number GFZ @ kyba @ Serial 2525  
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