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Author Point, S.
Title (up) Blue Light Hazard: are exposure limit values protective enough for newborn infants? Type Journal Article
Year 2018 Publication Radioprotection Abbreviated Journal
Volume 53 Issue 3 Pages 219-224
Keywords Human Health
Abstract Blue Light Hazard is an emerging concern for health of population. Nevertheless, acute exposure to blue rays from artificial light is well taken into account by normative requirements applicable to lamps engineering and risk for general population is low. There is also no evidence for a chronic effect of artificial lighting on retina for general population at radiance below exposure limit values. That said, children in the very first years of life constitute a specific population to consider. On one side, eye anatomy of very young infants is different from elder young people or adults. On the other side, infants can be in close contact with some luminous toys or night lights. This paper presents a first approach for taking into account the specific anatomy of newborn infants’ eyes in blue light hazard evaluation. Results show that differences of crystalline lens transparency, focal length and pupil diameter could induce a significantly higher retinal exposure than for adult.
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Call Number GFZ @ kyba @ Serial 1982
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Author Wang, H.-B.; Whittaker, D.S.; Truong, D.; Mulji, A.K.; Ghiani, C.A.; Loh, D.H.; Colwell, C.S.
Title (up) Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease Type Journal Article
Year 2017 Publication Neurobiology of Sleep and Circadian Rhythms Abbreviated Journal Neurobiology of Sleep and Circadian Rhythms
Volume 2 Issue Pages 39-52
Keywords animals; Human Health
Abstract Patients with Huntington's disease (HD) exhibit movement disorders, psychiatric disturbance and cognitive impairments as the disease progresses. Abnormal sleep/wake cycles are common among HD patients with reports of delayed sleep onset, fatigue during the day, and a delayed pattern of melatonin secretion all of which suggest circadian dysfunction. Mouse models of HD confirm disrupted circadian rhythms with pathophysiology found in the central circadian clock (suprachiasmatic nucleus). Importantly, circadian dysfunction manifests early in disease, even before the classic motor symptoms, in both patients and mouse models. Therefore, we hypothesize that the circadian dysfunction may interact with the disease pathology and exacerbate the HD symptoms. If correct, early intervention may benefit patients and delay disease progression. One test of this hypothesis is to determine whether light therapy designed to strengthen this intrinsic timing system can delay the disease progression in mouse models. Therefore, we determined the impact of blue wavelength-enriched light on two HD models: the BACHD and Q175 mice. Both models received 6 hours of blue-light at the beginning of their daily light cycle for 3 months. After treatment, both genotypes showed improvements in their locomotor activity rhythm without significant change to their sleep behavior. Critically, treated mice of both lines exhibited improved motor performance compared to untreated controls. Focusing on the Q175 genotype, we sought to determine whether the treatment altered signaling pathways in brain regions known to be impacted by HD using NanoString gene expression assays. We found that the expression of several HD relevant markers was altered in the striatum and cortex of the treated mice. Our study demonstrates that strengthening the circadian system can delay the progression of HD in pre-clinical models. This work suggests that lighting conditions should be considered when managing treatment of HD and other neurodegenerative disorders.
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ISSN 2451-9944 ISBN Medium
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Call Number LoNNe @ kyba @ Serial 1626
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Author Welz, P.-S.; Zinna, V.M.; Symeonidi, A.; Koronowski, K.B.; Kinouchi, K.; Smith, J.G.; Guillen, I.M.; Castellanos, A.; Crainiciuc, G.; Prats, N.; Caballero, J.M.; Hidalgo, A.; Sassone-Corsi, P.; Benitah, S.A.
Title (up) BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis Type Journal Article
Year 2019 Publication Cell Abbreviated Journal Cell
Volume 177 Issue 6 Pages 1436-1447.e12
Keywords Animals
Abstract Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues.
Address Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; ICREA, Catalan Institution for Research and Advanced Studies, 08010 Barcelona, Spain. Electronic address: salvador.aznar-benitah@irbbarcelona.org
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ISSN 0092-8674 ISBN Medium
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Notes PMID:31150620 Approved no
Call Number GFZ @ kyba @ Serial 2513
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Author Filho, C.R.D.S.; Zullo Jr, J.; Elvidge, C.
Title (up) Brazil's 2001 energy crisis monitored from space Type Journal Article
Year 2004 Publication International Journal of Remote Sensing Abbreviated Journal International Journal of Remote Sensing
Volume 25 Issue 12 Pages 2475-2482
Keywords Remote Sensing; Energy
Abstract Data sensed by the US Air Force Defence Meteorological Satellite Program (DMSP) Operational Linescan System (OLS) during the years 2000 and 2001 in Brazil were tested as a tool to monitor reduction of nocturnal lighting. This particular timing was examined as the Brazilian population and industry were forced to reduce electric power consumption by 20% during 2001, in relation to 2000, for a period of several months, starting officially on 1 June 2001. Large urban agglomerates were compelled to switch off city lights by at least the same amount. The Distrito Federal (DF), including the Brazilian capital, Brasilia, was one of the primary areas where the government actively sought electric power consumption reductions. Using the DF as a study case, we demonstrate that the mean grey levels derived from averaging DMSP-OLS data acquired over urban centres appear to be a useful index to monitor relative oscillations in energy consumption.
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ISSN 0143-1161 ISBN Medium
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Notes Approved no
Call Number GFZ @ kyba @ Serial 2362
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Author Shlesinger, T.; Loya, Y.
Title (up) Breakdown in spawning synchrony: A silent threat to coral persistence Type Journal Article
Year 2019 Publication Science (New York, N.Y.) Abbreviated Journal Science
Volume 365 Issue 6457 Pages 1002-1007
Keywords Animals; Coral
Abstract The impacts of human and natural disturbances on coral reefs are typically quantified through visible damage (e.g., reduced coral coverage as a result of bleaching events), but changes in environmental conditions may also cause damage in less visible ways. Despite the current paradigm, which suggests consistent, highly synchronized spawning events, corals that reproduce by broadcast spawning are particularly vulnerable because their reproductive phenology is governed by environmental cues. Here, we quantify coral spawning intensity during four annual reproductive seasons, alongside laboratory analyses at the polyp, colony, and population levels, and we demonstrate that, compared with historical data, several species from the Red Sea have lost their reproductive synchrony. Ultimately, such a synchrony breakdown reduces the probability of successful fertilization, leading to a dearth of new recruits, which may drive aging populations to extinction.
Address School of Zoology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel
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ISSN 0036-8075 ISBN Medium
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Notes PMID:31488683 Approved no
Call Number GFZ @ kyba @ Serial 2673
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