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Author Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L.
Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
Year (down) 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol
Volume in press Issue Pages
Keywords Vision
Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.
Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0340-5761 ISBN Medium
Area Expedition Conference
Notes PMID:30778631 Approved no
Call Number GFZ @ kyba @ Serial 2229
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Author Youngstedt, S.D.; Elliott, J.A.; Kripke, D.F.
Title Human Circadian Phase-Response Curves for Exercise Type Journal Article
Year (down) 2019 Publication The Journal of Physiology Abbreviated Journal J Physiol
Volume in press Issue Pages
Keywords Human Health
Abstract KEY POINTS: Exercise elicits circadian phase-shifting effects, but additional information is needed. The phase-response curve describing the magnitude and direction of circadian rhythm phase shifts depending on the time of the zeigeber (time cue) stimulus is the most fundamental chronobiological tool for alleviating circadian misalignment and related morbidity. 51 older and 48 young adults followed a circadian rhythms measurement protocol for up to 5.5 days, and performed 1 h of moderate treadmill exercise for 3 consecutive days at one of 8 times of day/night. Temporal changes in the phase of 6-sulphatoxymelatonin (aMT6s) were measured from evening onset, cosine acrophase, morning offset, and duration of excretion, establishing significant PRCs for aMT6 onset and acrophase with large phase delays from 7-10 PM and large phase advances at both 7 AM and 1-4 PM. Along with known synergism with bright light, the above PRCs with a second phase advance region (afternoon) could support both practical and clinical applications. ABSTRACT: Although bright light is regarded as the primary circadian zeitgeber, its limitations support exploring alternative zeitgebers. Exercise elicits significant circadian phase-shifting effects, but fundamental information regarding these effects is needed. The primary aim of this study was to establish phase-response curves (PRC) documenting the size and direction of phase shifts in relation to the circadian time of exercise. Aerobically fit older (n = 51, 59-75 y) and young adults (n = 48, 18-30 y) followed a 90-min laboratory ultra-short sleep wake cycle (60 min wake/30 min sleep) for up to 5 (1/2) days. At the same clock time on three consecutive days, each participant performed 60 min of moderate treadmill exercise (65-75% of heart rate reserve) at one of 8 times of day/night. To describe PRCs, phase shifts were measured for the cosine-fitted acrophase of urinary 6-sulphatoxymelatonin (aMT6s), as well as for the evening rise, morning decline, and change in duration of aMT6s excretion. Significant PRCs were found for aMT6s acrophase, onset and duration, with peak phase advances corresponding to clock times of 7 AM and 1PM-4PM, delays from 7 PM-10 PM, and minimal shifts around 4 PM and 2 AM. There were no significant age or sex differences. The amplitudes of the aMT6s onset and acrophase PRCs are comparable to expectations for bright light of equal duration. The phase advance to afternoon exercise and the exercise-induced PRC for change in aMT6s duration are novel findings. The results support further research exploring additive phase shifting effects of bright light and exercise and health benefits. This article is protected by copyright. All rights reserved.
Address Department of Psychiatry, University of California, San Diego, CA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-3751 ISBN Medium
Area Expedition Conference
Notes PMID:30784068 Approved no
Call Number GFZ @ kyba @ Serial 2230
Permanent link to this record
 

 
Author Clayson, Hollis
Title Illuminated Paris, Essays on Art and Lighting in the Belle Époque Type Book Whole
Year (down) 2019 Publication Abbreviated Journal
Volume Issue Pages
Keywords History; Society; Art
Abstract
Address Chicago
Corporate Author Thesis
Publisher University of Chicago Press Place of Publication Chicago Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 9780226593869 Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2231
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Author Canazei, M.; Pohl, W.; Weninger, J.; Bliem, H.; Weiss, E.M.; Koch, C.; Berger, A.; Firulovic, B.; Marth, C.
Title Effects of adjustable dynamic bedroom lighting in a maternity ward Type Journal Article
Year (down) 2019 Publication Journal of Environmental Psychology Abbreviated Journal Journal of Environmental Psychology
Volume 62 Issue Pages 59-66
Keywords Human Health
Abstract There exists initial evidence for beneficial daylight effects in hospital bedrooms. However, study results with automatically controlled dynamic bedroom lights were so far inconclusive. It can be hypothesized that inclusion of critically ill patients and unpleasant fixed bright light stimuli so far could have masked non-visual light effects on patient's sleep, mood and circadian physiology.

Therefore, a temporarily adjustable dynamic light was installed in double bedrooms in a maternity clinic. Although mothers were exposed to fixed morning bright light under dynamic light they were allowed to adjust light intensities the rest of the day. In contrast, light colours were automatically changed over 24 h and could not be altered. Double bedrooms with standard switchable light were utilized as active control condition.

A sample of 72 women, giving birth to healthy term babies, were randomly assigned to bedrooms with dynamic or standard light. Light conditions adjusted by mothers, sleep quality, mood and diurnal melatonin level, as well as physical activity levels of mothers and neonates, were recorded.

Mothers exposed themselves and their babies to higher daytime and lower evening light levels under dynamic light compared to standard light after the period of fixed morning bright light exposure had ended. Although no overall effects on maternal parameters could be observed under dynamic light, we could reveal an earlier daily onset of neonatal physical activity levels in these bedrooms.

To conclude, this study indicates that an adjustable dynamic light may substantially affect indoor light exposure in a maternity ward. Further studies are necessary to explore light effects on mothers and substantiate study results on neonates.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0272-4944 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2232
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Author Pagden, M.; Ngahane, K.; Amin, M.S.R.
Title Changing the colour of night on urban streets – LED vs. part-night lighting system Type Journal Article
Year (down) 2019 Publication Socio-Economic Planning Sciences Abbreviated Journal Socio-Economic Planning Sciences
Volume in press Issue Pages
Keywords Energy; Planning; Economics
Abstract Many cities in the United Kingdom are upgrading the streetlights to white light-emitting diode (LED) lamps for reducing the electricity costs and attaining the sustainable energy solutions. Installation of LED lamps on urban street requires higher installation costs and a long-term period to payback benefits of replacing outdated streetlights in terms of energy savings and costs. To achieve the short-term energy efficiency of urban street lighting, city councils sometimes adopt the part-night lighting system particularly in the residential areas. The Coventry City Council recently replaced 29,701 existing sodium lights with LED lamps. This paper performs the economic analyses to understand the feasibility of two street lighting systems: LED lamps and ‘part-night’ lightings on the Coventry streets during the twenty-year period assuming the return period of investment is twenty years. The projection of energy consumption and costs for LED lamps and part-night lighting systems shows that electricity can be saved by 44% and 21% comparing to current electricity usages, respectively. Considering the budgetary constraints of Coventry City Council, this paper concludes that the part-night lighting system may be beneficial in short-term period, but it is economically feasible to replace the existing lower efficiency lights with LED lamps.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0038-0121 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2234
Permanent link to this record