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Author (up) Walker, W.H. 2nd; Melendez-Fernandez, O.H.; Nelson, R.J.
Title Prior exposure to dim light at night impairs dermal wound healing in female C57BL/6 mice Type Journal Article
Year 2019 Publication Archives of Dermatological Research Abbreviated Journal Arch Dermatol Res
Volume 311 Issue 7 Pages 573-576
Keywords Animals; mouse models; Skin; Human Health
Abstract Artificial light at night (LAN) is a pervasive phenomenon in today's society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effects of dim LAN (DLAN) on wound healing. Female C57BL/6 mice were housed for 3 weeks in DLAN or LD conditions prior to wounding. Following wounding, mice were maintained in either their previous light conditions or switched to the opposite lighting conditions for 3 weeks. DLAN prior to wounding impaired healing; specifically, mice in DLAN/DLAN had significantly larger wounds on day 8. Additionally, mice in DLAN/LD had significantly larger wounds on days 5, 7, 8, and 9, and increased average time to closure. These data demonstrate a potential harmful effect of DLAN on wound healing that should be considered and may represent a target for therapeutic intervention.
Address Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0340-3696 ISBN Medium
Area Expedition Conference
Notes PMID:31144020 Approved no
Call Number GFZ @ kyba @ Serial 2515
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