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Author Schernhammer, E.S.; Schulmeister, K.
Title Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels? Type Journal Article
Year (up) 2004 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume 90 Issue 5 Pages 941-943
Keywords Human Health; Animals; Circadian Rhythm/*radiation effects; Humans; Light/*adverse effects; Melatonin/*blood; Neoplasms/blood/*etiology; Risk Factors
Abstract The suprachiasmatic nuclei in the hypothalamus, one of the most important physiological determinants of alertness and performance, drive a circadian pacemaker in mammals, with an intrinsic period averaging 24 h. Light is the primary stimulus to the disruption and resetting of this pacemaker, which is expressed in changing melatonin rhythms. Melatonin production in humans decreases when people are exposed to light at night. Since melatonin shows potential oncostatic action in a variety of tumours, it is possible that lowered serum melatonin levels caused by exposure to light at night enhance the general tumour development. Cancer is the second leading cause of death in industrialised countries like the United States, where a significant proportion of workers engage in shift work, making a hypothesised relation between light exposure at night and cancer risk relevant. Observational studies support an association between night work and cancer risk. We hypothesise that the potential primary culprit for this observed association is the lack of melatonin, a cancer-protective agent whose production is severely diminished in people exposed to light at night.
Address Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. eva.schernhammer@channing.harvard.edu
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ISSN 0007-0920 ISBN Medium
Area Expedition Conference
Notes PMID:14997186; PMCID:PMC2409637 Approved no
Call Number LoNNe @ kagoburian @ Serial 805
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Author Fritschi, L.; Erren, T.C.; Glass, D.C.; Girschik, J.; Thomson, A.K.; Saunders, C.; Boyle, T.; El-Zaemey, S.; Rogers, P.; Peters, S.; Slevin, T.; D'Orsogna, A.; de Vocht, F.; Vermeulen, R.; Heyworth, J.S.
Title The association between different night shiftwork factors and breast cancer: a case-control study Type Journal Article
Year (up) 2013 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume 109 Issue 9 Pages 2472-2480
Keywords Adult; Aged; Aged, 80 and over; Breast Neoplasms/*epidemiology/etiology; Case-Control Studies; Female; Humans; Life Style; Middle Aged; Questionnaires; Risk; Risk Factors; Western Australia/epidemiology; *Work Schedule Tolerance; Young Adult; oncogenesis
Abstract BACKGROUND: Research on the possible association between shiftwork and breast cancer is complicated because there are many different shiftwork factors, which might be involved including: light at night, phase shift, sleep disruption and changes in lifestyle factors while on shiftwork (diet, physical activity, alcohol intake and low sun exposure). METHODS: We conducted a population-based case-control study in Western Australia from 2009 to 2011 with 1205 incident breast cancer cases and 1789 frequency age-matched controls. A self-administered questionnaire was used to collect demographic, reproductive, and lifestyle factors and lifetime occupational history and a telephone interview was used to obtain further details about the shiftwork factors listed above. RESULTS: A small increase in risk was suggested for those ever doing the graveyard shift (work between midnight and 0500 hours) and breast cancer (odds ratio (OR)=1.16, 95% confidence interval (CI)=0.97-1.39). For phase shift, we found a 22% increase in breast cancer risk (OR=1.22, 95% CI=1.01-1.47) with a statistically significant dose-response relationship (P=0.04). For the other shiftwork factors, risks were marginally elevated and not statistically significant. CONCLUSION: We found some evidence that some of the factors involved in shiftwork may be associated with breast cancer but the ORs were low and there were inconsistencies in duration and dose-response relationships.
Address Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia
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ISSN 0007-0920 ISBN Medium
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Notes PMID:24022188; PMCID:PMC3817316 Approved no
Call Number IDA @ john @ Serial 153
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Author Johns, L.E.; Jones, M.E.; Schoemaker, M.J.; McFadden, E.; Ashworth, A.; Swerdlow, A.J.
Title Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study Type Journal Article
Year (up) 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume 118 Issue Pages 600-606
Keywords Human Health
Abstract BACKGROUND: Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed. METHODS: We investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire. Analyses were conducted on 105 866 participants with no prior history of breast cancer. During an average of 6.1 years of follow-up, 1775 cases of breast cancer were diagnosed. Cox proportional hazard models were used to calculate hazard ratios (HRs), adjusting for potential confounding factors. RESULTS: There was no association between LAN level and breast cancer risk overall (highest compared with lowest LAN level at recruitment: HR=1.01, 95% confidence interval (CI): 0.88-1.15), or for invasive (HR=0.98, 95% CI: 0.85-1.13) or in situ (HR=0.96, 95% CI: 0.83-1.11) breast cancer, or oestrogen-receptor (ER) positive (HR=0.98, 95% CI: 0.84-1.14); or negative (HR=1.16, 95% CI: 0.82-1.65) tumours separately. The findings did not differ by menopausal status. Adjusting for sleep duration, sleeping at unusual times (non-peak sleep) and history of night work did not affect the results. Night waking with exposure to light, occurring around age 20, was associated with a reduced risk of premenopausal breast cancer (HR for breast cancer overall=0.74, 95% CI: 0.55-0.99; HR for ER-positive breast cancer=0.69, 95% CI: 0.49-0.97). CONCLUSIONS: In this prospective cohort analysis of LAN, there was no evidence that LAN exposure increased the risk of subsequent breast cancer, although the suggestion of a lower breast cancer risk in pre-menopausal women with a history of night waking in their twenties may warrant further investigation.British Journal of Cancer advance online publication, 23 January 2018; doi:10.1038/bjc.2017.359 www.bjcancer.com.
Address Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK
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ISSN 0007-0920 ISBN Medium
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Notes PMID:29360812 Approved no
Call Number LoNNe @ kyba @ Serial 1803
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Author Mortazavi, S.M.J.
Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
Year (up) 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume 118 Issue 11 Pages 1536
Keywords Commentary
Abstract
Address Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran. S.M.Javad.Mortazavi@fccc.edu
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ISSN 0007-0920 ISBN Medium
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Notes PMID:29769746 Approved no
Call Number GFZ @ kyba @ Serial 1911
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Author Stevens, R.G.
Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
Year (up) 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume in press Issue Pages
Keywords Commentary; Human Health
Abstract
Address University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT, 06032, USA. bugs@uchc.edu
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ISSN 0007-0920 ISBN Medium
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Notes PMID:30283145 Approved no
Call Number GFZ @ kyba @ Serial 2035
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Author Kyba, C.C.M.; Spitschan, M.
Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105000 UK women in the Generations Study' Type Journal Article
Year (up) 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume in press Issue Pages
Keywords Human Health; Commentary
Abstract
Address Department of Experimental Psychology, University of Oxford, Oxford, UK
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Language English Summary Language Original Title
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ISSN 0007-0920 ISBN Medium
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Notes PMID:30584260 Approved no
Call Number GFZ @ kyba @ Serial 2145
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