|   | 
Details
   web
Records
Author Cajochen, C.; Munch, M.; Kobialka, S.; Krauchi, K.; Steiner, R.; Oelhafen, P.; Orgul, S.; Wirz-Justice, A.
Title High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light Type Journal Article
Year 2005 Publication (up) The Journal of Clinical Endocrinology and Metabolism Abbreviated Journal J Clin Endocrinol Metab
Volume 90 Issue 3 Pages 1311-1316
Keywords Human Health; Adult; Body Temperature Regulation/physiology/*radiation effects; Circadian Rhythm/physiology/radiation effects; Color; Heart Rate/physiology/*radiation effects; Humans; *Light; Male; Melatonin/*metabolism; Retinal Cone Photoreceptor Cells/physiology; Sleep Stages/physiology/radiation effects; Wakefulness/physiology/*radiation effects
Abstract Light can elicit acute physiological and alerting responses in humans, the magnitude of which depends on the timing, intensity, and duration of light exposure. Here, we report that the alerting response of light as well as its effects on thermoregulation and heart rate are also wavelength dependent. Exposure to 2 h of monochromatic light at 460 nm in the late evening induced a significantly greater melatonin suppression than occurred with 550-nm monochromatic light, concomitant with a significantly greater alerting response and increased core body temperature and heart rate ( approximately 2.8 x 10(13) photons/cm(2)/sec for each light treatment). Light diminished the distal-proximal skin temperature gradient, a measure of the degree of vasoconstriction, independent of wavelength. Nonclassical ocular photoreceptors with peak sensitivity around 460 nm have been found to regulate circadian rhythm function as measured by melatonin suppression and phase shifting. Our findings-that the sensitivity of the human alerting response to light and its thermoregulatory sequelae are blue-shifted relative to the three-cone visual photopic system-indicate an additional role for these novel photoreceptors in modifying human alertness, thermophysiology, and heart rate.
Address Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr. 27, CH-4025 Basel, Switzerland. christian.cajochen@pukbasel.ch
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0021-972X ISBN Medium
Area Expedition Conference
Notes PMID:15585546 Approved no
Call Number LoNNe @ kagoburian @ Serial 728
Permanent link to this record
 

 
Author Lockley, S.W.; Brainard, G.C.; Czeisler, C.A.
Title High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light Type Journal Article
Year 2003 Publication (up) The Journal of Clinical Endocrinology and Metabolism Abbreviated Journal J Clin Endocrinol Metab
Volume 88 Issue 9 Pages 4502-4505
Keywords Human Health; Adult; Area Under Curve; Circadian Rhythm/*radiation effects; Female; Humans; *Light; Male; Melatonin/*metabolism; Pineal Gland/metabolism/radiation effects; Saliva/metabolism; Non-programmatic
Abstract The endogenous circadian oscillator in mammals, situated in the suprachiasmatic nuclei, receives environmental photic input from specialized subsets of photoreceptive retinal ganglion cells. The human circadian pacemaker is exquisitely sensitive to ocular light exposure, even in some people who are otherwise totally blind. The magnitude of the resetting response to white light depends on the timing, intensity, duration, number and pattern of exposures. We report here that the circadian resetting response in humans, as measured by the pineal melatonin rhythm, is also wavelength dependent. Exposure to 6.5 h of monochromatic light at 460 nm induces a two-fold greater circadian phase delay than 6.5 h of 555 nm monochromatic light of equal photon density. Similarly, 460 nm monochromatic light causes twice the amount of melatonin suppression compared to 555 nm monochromatic light, and is dependent on the duration of exposure in addition to wavelength. These studies demonstrate that the peak of sensitivity of the human circadian pacemaker to light is blue-shifted relative to the three-cone visual photopic system, the sensitivity of which peaks at approximately 555 nm. Thus photopic lux, the standard unit of illuminance, is inappropriate when quantifying the photic drive required to reset the human circadian pacemaker.
Address Division of Sleep Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0021-972X ISBN Medium
Area Expedition Conference
Notes PMID:12970330 Approved no
Call Number LoNNe @ kagoburian @ Serial 778
Permanent link to this record
 

 
Author Obayashi, K.; Saeki, K.; Kurumatani, N.
Title Ambient Light Exposure and Changes in Obesity Parameters: A Longitudinal Study of the HEIJO-KYO Cohort Type Journal Article
Year 2016 Publication (up) The Journal of Clinical Endocrinology and Metabolism Abbreviated Journal J Clin Endocrinol Metab
Volume Issue Pages jc20154123
Keywords Human Health
Abstract CONTEXT: Previous epidemiological studies have suggested an association between nighttime light levels and the prevalence of obesity, although evidence is limited to cross-sectional studies. OBJECTIVE: To evaluate the longitudinal association between ambient light exposure and the subsequent changes in obesity parameters. DESIGN AND PARTCIPANTS: Data from 1,110 elderly participants at baseline (mean age, 71.9 years) and data from 766 at follow-up (median, 21 months) were included in this prospective population-based study. MEASURES: Time-dependent ambient light exposure based on objective measurements and changes in the waist-to-height ratio (WHtR) and body mass index (BMI) were measured. RESULTS: Multivariable mixed-effect linear regression models showed a significant association between light exposure and the %WHtR gain; this was independent of potential confounders (e.g., caloric intake, physical activity, and sleep/wake parameters). Nighttime or evening exposure to higher light intensity was significantly associated with subsequent %WHtR gain. Morning exposure to a longer time >/=500 lux or nighttime exposure to a longer time <3 lux was significantly associated with subsequent %WHtR loss. These association trends were nearly consistent when the BMI was used as an obesity parameter. Increased nighttime light exposure (mean >/=3 vs. <3 lux) was estimated to correspond to a 10.2% WHtR gain and 10.0% increase in BMI over 10 years. CONCLUSIONS: Ambient light exposure, such as increased nighttime or evening light exposure and decreased morning light exposure, was independently associated with subsequent increases in obesity parameters. Further interventional studies are warranted to establish an optimal controlled lighting environment as a preventive option against obesity.
Address Department of Community Health and Epidemiology, Nara Medical University School of Medicine, Nara, Japan
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0021-972X ISBN Medium
Area Expedition Conference
Notes PMID:27383113 Approved no
Call Number LoNNe @ kyba @ Serial 1483
Permanent link to this record
 

 
Author Sahar, S.; Sassone-Corsi, P.
Title Regulation of metabolism: the circadian clock dictates the time Type Journal Article
Year 2012 Publication (up) Trends in Endocrinology and Metabolism: TEM Abbreviated Journal Trends Endocrinol Metab
Volume 23 Issue 1 Pages 1-8
Keywords Animals; Chronobiology Disorders/metabolism; *Circadian Clocks; *Circadian Rhythm; Circadian Rhythm Signaling Peptides and Proteins/metabolism; *Energy Metabolism; Humans; Metabolome
Abstract Circadian rhythms occur with a periodicity of approximately 24h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders.
Address Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA 92697, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1043-2760 ISBN Medium
Area Expedition Conference
Notes PMID:22169754; PMCID:PMC3259741 Approved no
Call Number IDA @ john @ Serial 151
Permanent link to this record
 

 
Author Qian, J.; Scheer, F.A.J.L.
Title Circadian System and Glucose Metabolism: Implications for Physiology and Disease Type Journal Article
Year 2016 Publication (up) Trends in Endocrinology and Metabolism: TEM Abbreviated Journal Trends Endocrinol Metab
Volume 27 Issue 5 Pages 282-293
Keywords Human Health; circadian rhythms; food timing; glucose metabolism; melatonin; sleep; type 2 diabetes
Abstract The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-h rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Recent studies indicate that the circadian system is important in regulating the daily rhythm in glucose metabolism. Disturbance of this circadian control or of its coordination relative to the environmental/behavioral cycle, such as in shift work, eating late, or due to genetic changes, results in disturbed glucose control and increased type 2 diabetes risk. Therefore, an in-depth understanding of the mechanisms underlying glucose regulation by the circadian system and its disturbance may help in the development of therapeutic interventions against the deleterious health consequences of circadian disruption.
Address Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; fscheer(at)bwh.harvard.edu
Corporate Author Thesis
Publisher Cell Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1043-2760 ISBN Medium
Area Expedition Conference
Notes PMID:27079518; PMCID:PMC4842150 Approved no
Call Number IDA @ john @ Serial 1446
Permanent link to this record