| Records |
Author  |
Figueiro, M.G.; Rea, M.S.; Bullough, J.D. |
| Title |
Does architectural lighting contribute to breast cancer? |
Type |
Journal Article |
| Year |
2006 |
Publication |
Journal of Carcinogenesis |
Abbreviated Journal |
J Carcinog |
| Volume |
5 |
Issue |
|
Pages |
20 |
| Keywords |
Human Health |
| Abstract |
OBJECTIVES: There is a growing interest in the role that light plays on nocturnal melatonin production and, perhaps thereby, the incidence of breast cancer in modern societies. The direct causal relationships in this logical chain have not, however, been fully established and the weakest link is an inability to quantitatively specify architectural lighting as a stimulus for the circadian system. The purpose of the present paper is to draw attention to this weakness. DATA SOURCES AND EXTRACTION: We reviewed the literature on the relationship between melatonin, light at night, and cancer risk in humans and tumor growth in animals. More specifically, we focused on the impact of light on nocturnal melatonin suppression in humans and on the applicability of these data to women in real-life situations. Photometric measurement data from the lighted environment of women at work and at home is also reported. DATA SYNTHESIS: The literature review and measurement data demonstrate that more quantitative knowledge is needed about circadian light exposures actually experienced by women and girls in modern societies. CONCLUSION: Without such quantitative knowledge, limited insights can be gained about the causal relationship between melatonin and the etiology of breast cancer from epidemiological studies and from parametric studies using animal models. |
| Address |
Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street Troy, NY 12180 USA. figuem@rpi.edu |
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Place of Publication |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1477-3163 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16901343; PMCID:PMC1557490 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
746 |
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| Author |
Ishikawa, R.; Shinomura, T.; Takano, M.; Shimamoto, K. |
| Title |
Phytochrome dependent quantitative control of Hd3a transcription is the basis of the night break effect in rice flowering |
Type |
Journal Article |
| Year |
2009 |
Publication |
Genes & Genetic Systems |
Abbreviated Journal |
Genes Genet Syst |
| Volume |
84 |
Issue |
2 |
Pages |
179-184 |
| Keywords |
Plants; Flowers/*genetics/growth & development; Gene Expression Regulation, Developmental/drug effects; Gene Expression Regulation, Plant/drug effects; Light; Mutation; Oryza/*genetics/growth & development; Photoperiod; Phytochrome B/genetics/*physiology; Plant Proteins/*genetics; Transcription, Genetic |
| Abstract |
A short exposure to light during relative night (night break; NB) delays flowering in the short day plant rice. NB acts by downregulating Heading date 3a (Hd3a) expression. Because phytochrome B mutants do not respond to NB and their flowering time is not affected even under NB conditions, phyB is required for the suppression of Hd3a expression. The effect of NB is quantitatively controlled by light quality and by either light intensity or duration. However, the molecular mechanisms that regulate these interactions are poorly understood. Here, we examine the roles of phytochromes in the regulation of Hd3a transcription under NB conditions using monochromatic red, far-red and blue light. Red and blue light downregulated Hd3a expression, but far-red light NB did not. The effect of red light NB on Hd3a is dependent on photon fluence and is restored by subsequent far-red light irradiation. Our results suggest that quantitative effect of light on flowering in rice NB is mediated by the regulation of Hd3a transcription by phyB. |
| Address |
Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology, Takayama, Ikoma, Japan |
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Place of Publication |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1341-7568 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:19556711 |
Approved |
no |
| Call Number |
GFZ @ kyba @ |
Serial |
3345 |
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| Author |
Khan, S.; Yong, V.W.; Xue, M. |
| Title |
Circadian disruption in mice through chronic jetlag-like conditions modulates molecular profiles of cancer in nucleus accumbens and prefrontal cortex |
Type |
Journal Article |
| Year |
2021 |
Publication |
Carcinogenesis |
Abbreviated Journal |
Carcinogenesis |
| Volume |
in press |
Issue |
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Pages |
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| Keywords |
Animals; Brain activity; Cancer pathways; Chronic jetlag (CJL); Metabolic pathways; Shiftwork |
| Abstract |
Biological rhythms regulate physiological activities. Shiftwork disrupts normal circadian rhythms and may increase the risk of cancer through unknown mechanisms. To mimic environmental light/dark changes encountered by shift workers, a protocol called “chronic jet lag (CJL)” induced by repeatedly shifting light-dark cycles has been used. Here, we subjected mice to CJL by advancing light-dark cycle by 6 hours every 2 days, and conducted RNA sequencing to analyze the expression profile and molecular signature in the brain areas of prefrontal cortex and nucleus accumbens. We also performed positron emission tomography (PET) imaging to monitor changes related to glucose metabolism in brain. Our results reveal systematic reprogramming of gene expression associated with cancer related pathways and metabolic pathways in prefrontal cortex and nucleus accumbens. PET imaging indicates that glucose uptake level was significantly reduced in whole brain as well as the individual brain regions. Moreover, qPCR analysis describes that the expression levels of cancer related genes were altered in prefrontal cortex and nucleus accumbens. Overall, these results suggest a molecular and metabolic link with CJL mediated cancer risk, and generate hypotheses on how CJL increases the susceptibility to cancer. |
| Address |
Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, Henan, China |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0143-3334 |
ISBN |
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Expedition |
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Conference |
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| Notes |
PMID:33608694 |
Approved |
no |
| Call Number |
GFZ @ kyba @ |
Serial |
3421 |
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| Author |
Shor, E.; Potavskaya, R.; Kurtz, A.; Paik, I.; Huq, E.; Green, R. |
| Title |
PIF-mediated sucrose regulation of the circadian oscillator is light quality and temperature dependent |
Type |
Journal Article |
| Year |
2018 |
Publication |
Genes |
Abbreviated Journal |
Genes (Basel) |
| Volume |
9 |
Issue |
12 |
Pages |
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| Keywords |
Plants |
| Abstract |
Studies are increasingly showing that metabolic and circadian (~24 h) pathways are strongly interconnected, with the circadian system regulating the metabolic state of the cell, and metabolic products feeding back to entrain the oscillator. In plants, probably the most significant impact of the circadian system on metabolism is in its reciprocal regulation of photosynthesis; however, the pathways by which this occurs are still poorly understood. We have previously shown that members of the basic helix-loop-helix (bHLH) transcription factor PHYTOCHROME INTERACTING FACTOR (PIF) family are involved in the photosynthate entrainment of the circadian oscillator. In this paper, using Arabidopsis mutants and overexpression lines, we examine how temperature and light quality affect PIF-mediated sucrose signaling to the oscillator and examine the contributions of individual PIF members. Our results also show that the quality of light is important for PIF signaling, with red and blue lights having the opposite effects, and that temperature affects PIF-mediated sucrose signaling. We propose the light sensitivity of PIF-mediated sucrose entrainment of the oscillator may be important in enabling plants to distinguish between sucrose produced de novo from photosynthesis during the day and the sucrose products of starch degradation at the end of the night. |
| Address |
Department of Plant and Environmental Sciences, Institute for Life Sciences, Edmond J. Safra Campus, Givat Ram, Hebrew University, Jerusalem 91904, Israel. rgreen@mail.huji.ac.il |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
2073-4425 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:30551669; PMCID:PMC6316277 |
Approved |
no |
| Call Number |
GFZ @ kyba @ |
Serial |
2155 |
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| Author |
Stevens, R.G. |
| Title |
Working against our endogenous circadian clock: Breast cancer and electric lighting in the modern world |
Type |
Journal Article |
| Year |
2009 |
Publication |
Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
Abbreviated Journal |
Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Volume |
680 |
Issue |
1-2 |
Pages |
106-108 |
| Keywords |
Human Health |
| Abstract |
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Place of Publication |
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Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1383-5718 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
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Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
819 |
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