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Author (up) An, K.; Zhao, H.; Miao, Y.; Xu, Q.; Li, Y.-F.; Ma, Y.-Q.; Shi, Y.-M.; Shen, J.-W.; Meng, J.-J.; Yao, Y.-G.; Zhang, Z.; Chen, J.-T.; Bao, J.; Zhang, M.; Xue, T.
Title A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice Type Journal Article
Year 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci
Volume in press Issue Pages
Keywords Human Health
Abstract Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC-->dpHb-->NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.
Address Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. xuetian@ustc.edu.cn
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1097-6256 ISBN Medium
Area Expedition Conference
Notes PMID:32483349 Approved no
Call Number GFZ @ kyba @ Serial 2978
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Author (up) LeGates, T.A.; Kvarta, M.D.
Title Illuminating a path from light to depression Type Journal Article
Year 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci
Volume in press Issue Pages
Keywords Commentary; Animals; Human Health
Abstract Our light environment can strongly influence our mental health. Kai An and colleagues dissect the neuronal circuit mediating depression-related behaviors induced by mistimed light input in mice, implicating the nucleus accumbens as the downstream target of the neural pathway between intrinsically photosensitive retinal ganglion cells and the perihabenular nucleus.
Address Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1097-6256 ISBN Medium
Area Expedition Conference
Notes PMID:32555525 Approved no
Call Number GFZ @ kyba @ Serial 3015
Permanent link to this record