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Author Mindel, J.W.; Rojas, S.L.; Kline, D.; Bao, S.; Rezai, A.; Corrigan, J.D.; Nelson, R.J.; D, P.; Magalang, U.J.
Title 0038 Sleeping with Low Levels of Artificial Light at Night Increases Systemic Inflammation in Humans Type Journal Article
Year 2019 Publication Sleep Abbreviated Journal (down)
Volume 42 Issue Supplement_1 Pages A15-A16
Keywords Human Health
Abstract Introduction

Artificial light at night (ALAN) has become a ubiquitous part of our society. Animal studies have shown that ALAN exposure promotes a depressive-like mood and increases peripheral inflammation likely due to circadian disruption. We hypothesized that sleeping with ALAN will increase systemic inflammation in humans.

Methods

We enrolled 64 subjects [32 with obstructive sleep apnea (OSA) adherent to treatment and 32 without sleep disorders] in a randomized, crossover study to determine the effects of sleeping with ALAN (40 lux) or the usual dark condition (control) for 7 nights at home. Sleeping with ALAN was confirmed by an actigraph with an ambient light sensor. Outcome measurements were done at baseline and after sleeping in each condition. The primary outcome was changes in the high-sensitivity C-reactive protein (hsCRP) levels. Secondary outcomes include scores on the Pittsburgh Sleep Quality Index (PSQI), Center for Epidemiologic Studies Depression Scale (CES-D), Functional Outcomes of Sleep Questionnaire-10 (FOSQ-10), and Epworth Sleepiness Scale (ESS); Psychomotor Vigilance Testing (PVT); actigraphic sleep measures; and homeostatic model assessment of insulin resistance (HOMA-IR). A random effects linear regression model was used to assess differences adjusting for schedule, visit, and baseline levels. Post-hoc analyses combined results from OSA and non-OSA subjects.

Results

Fifty-eight (30 OSA and 28 non-OSA) subjects, aged 38.4±14.9 years, 33 of whom are male completed the protocol. A log transformation was used so the difference in hsCRP was expressed as a mean ratio. In the combined analysis, the mean hsCRP was 39% higher with ALAN than control (mean ratio=1.39; 95% CI: 1.08-1.80; p=0.012). The effects of ALAN for OSA and non-OSA subjects were not different. ALAN increased the CES-D score by 1.81 (p=0.017) and ESS score by 0.62 (p=0.071) points, and decreased the FOSQ-10 score by 0.36 (p=0.038) points while the PSQI score was unchanged (p=0.860). There were no significant differences in the PVT values, actigraphic sleep measures, or HOMA-IR.

Conclusion

Sleeping with ALAN for seven days significantly increased hsCRP levels and modestly increased depression scores in humans.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0161-8105 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2322
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Author Dhaliwal, S.S.; Keller, J.; Le, H.-N.; Lewin, D.S.
Title Sleep Disturbance among Pregnant Women: The Influence of Environmental and Contextual Factors Type Journal Article
Year 2019 Publication Sleep Abbreviated Journal (down)
Volume 42 Issue Supplement_1 Pages A270-A271
Keywords Human Health
Abstract Introduction

Disrupted sleep during pregnancy affects nearly 85% of women. This can contribute to psychological distress and antenatal depression. The aims of the current project were to test whether (a) poorer subjective sleep quality contributed to greater depression and anxiety symptoms, and (b) contextual factors predicted clinically significant sleep disturbance after adjusting for socioeconomic status (SES).

Methods

In a mixed-methods study, 418 pregnant women (age: M=32.4 years; gestation: M=28.4 weeks, SD=8.4 weeks; 58% Black) completed the Pittsburgh Sleep Quality Index (PSQI), measures of pregnancy-related physiological factors, and provided details about their sleep environment. They also rated perinatal depression, anxiety, and SES (Hollingshead and MacArthur Ladder). Sixty-two women completed these measures again later in pregnancy (gestation M = 34.2 weeks). A subset of seven women underwent actigraphy (9-nights) during their third trimester. Logistic regressions adjusted for age, BMI, race, sleep disordered breathing, and gestational week.

Results

Subjective sleep quality was significantly poorer among Black women and those with higher BMI. Physiological factors (i.e., restless leg syndrome, nocturnal urination, and acid reflux) explained subjective sleep disturbance after accounting for gestational week (ps<.01). Among women with history of psychopathology (n=221), sleep disturbance was significantly related to anxiety and depression symptoms (ps<.01), with greater sleep disturbance (PSQI score >5) predicting clinically significant antenatal depression (B = .38, p<.05). However, those who rated their social standing as higher reported lower sleep disturbance throughout pregnancy, even after adjusting for mood and anxiety (B= .86, SE =.41; p<.05). There was a dose-response positive association between sleep disturbance and depression severity among Black women only (B = .89; p<.05). Among lower SES Black women, environmental factors (greater ambient noise and light pollution) partially mediated this effect (B= .45, SE =.17; p<.01).

Conclusion

Sociocontextual factors may explain sleep disturbance severity among low-income pregnant Black women, above and beyond traditional metrics of SES. Higher subjective SES may be protective against sleep disturbance and psychiatric distress. Assessments of sleep during pregnancy should account for physiological considerations and environmental disruptions, alongside mood and anxiety.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0161-8105 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2323
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Author Choi, S. J., Park, H. R. & Joo, E. Y.
Title Effects of Light on Daytime Sleep in 12 Hours Night Shift Workers: A Field Study Type Journal Article
Year 2019 Publication Korean Sleep Research Society Abbreviated Journal (down)
Volume 16 Issue 1 Pages 26-35
Keywords Human Health; Sleep
Abstract Objectives: Night shift workers suffer from sleep and daytime disturbances due to circadian misalignment. To investigate the role of environmental light in daytime sleep following 12 h-night shift work. Methods: we enrolled 12 h-shift female nurses working at one university-affiliated hospital (n=10, mean age 26.6 years, shift work duration 3.8 years). This is a cross-over study to compare sleep between under light exposure (30 lux) and in the dark (<5 lux) following 12 h-night duty. Two sessions of experiments were underwent and the interval between sessions was about a month. Psychomotor vigilance test (PVT) had performed on awakening from sleep at each session and sleep-wake pattern had been monitored by actigraphy throughout the study period. Daytime sleep was also compared with night sleep of age-and gender matched daytime workers (n=10). Results: Sleep parameters and PVT scores were not different between two light conditions. Activities during sleep seemed to be more abundant under 30 lux condition than in the dark, which was not significant. Compared to night sleep, daytime sleep of shift workers was different in terms of rapid eye movement (REM) sleep. Three shift workers showed sleep onset REM sleep and first REM sleep period was the longest during daytime sleep. Conclusions: Unexpectedly, daytime sleep of 12 h night shift workers was well-maintained regardless of light exposure. Early occurrence of REM sleep and shorter sleep latency during daytime sleep suggest that shift workers meet with misalignment of circadian rhythm as well as increased homeostatic sleep pressure drive.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Korean Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ intern @ Serial 2635
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Author Woods, H. C., & Scott, H.
Title Merging the Biological and Cognitive Processes of Sleep and Screens Type Journal Article
Year 2019 Publication Current Sleep Medicine Reports Abbreviated Journal (down)
Volume 5 Issue 3 Pages 150-155
Keywords Human Health
Abstract Purpose of Review

Screens are a permanent feature of life today and we have reached an interesting juncture with different research agendas investigating the biological and cognitive aspects of screen use separately. This review argues that it is timely and indeed essential that we bring together these research areas to fully understand both positive and negative aspects of screen use.

Recent Findings

More recent work is starting to take a more cohesive approach to understanding how device use pre-bedtime can impact our sleep by including both light and content in their experimental protocols which is a welcome development leading to a more nuanced understanding of both biological and cognitive processes.

Summary

We call for an open and collaborative approach to gain momentum in this direction of acknowledging both biological and cognitive factors enabling us to understand the relative impacts of both whilst using screens with regard to both light and content.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ intern @ Serial 2640
Permanent link to this record