| Records |
| Author |
Sharkey, K.M.; Carskadon, M.A.; Figueiro, M.G.; Zhu, Y.; Rea, M.S. |
| Title |
Effects of an advanced sleep schedule and morning short wavelength light exposure on circadian phase in young adults with late sleep schedules |
Type |
Journal Article |
| Year |
2011 |
Publication |
Sleep Medicine |
Abbreviated Journal  |
Sleep Med |
| Volume |
12 |
Issue |
7 |
Pages |
685-692 |
| Keywords |
Affect/physiology/radiation effects; Circadian Rhythm/*physiology/*radiation effects; Color; Dose-Response Relationship, Radiation; Female; Humans; *Light; Male; Melatonin/metabolism; Photoperiod; Phototherapy/*methods; Saliva/metabolism; Sleep/physiology/radiation effects; Sleep Disorders, Circadian Rhythm/prevention & control/*therapy; Stress, Psychological/prevention & control/therapy; Treatment Outcome; Young Adult; blue light |
| Abstract |
OBJECTIVE: We examined the effects of an advanced sleep/wake schedule and morning short wavelength (blue) light in 25 adults (mean age+/-SD=21.8+/-3 years; 13 women) with late sleep schedules and subclinical features of delayed sleep phase disorder (DSPD). METHODS: After a baseline week, participants kept individualized, fixed, advanced 7.5-h sleep schedules for 6days. Participants were randomly assigned to groups to receive “blue” (470nm, approximately 225lux, n=12) or “dim” (<1lux, n=13) light for 1h after waking each day. Head-worn “Daysimeters” measured light exposure; actigraphs and sleep diaries confirmed schedule compliance. Salivary dim light melatonin onset (DLMO), self-reported sleep, and mood were examined with 2x2 ANOVA. RESULTS: After 6days, both groups showed significant circadian phase advances, but morning blue light was not associated with larger phase shifts than dim-light exposure. The average DLMO advances (mean+/-SD) were 1.5+/-1.1h in the dim light group and 1.4+/-0.7h in the blue light group. CONCLUSIONS: Adherence to a fixed advanced sleep/wake schedule resulted in significant circadian phase shifts in young adults with subclinical DSPD with or without morning blue light exposure. Light/dark exposures associated with fixed early sleep schedules are sufficient to advance circadian phase in young adults. |
| Address |
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Alpert Medical School of Brown University, Box G-RIH, Providence, RI 02912, USA. katherine_sharkey@brown.edu |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1389-9457 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:21704557; PMCID:PMC3145013 |
Approved |
no |
| Call Number |
IDA @ john @ |
Serial |
303 |
| Permanent link to this record |
| |
|
| |
| Author |
Dumont, M.; Beaulieu, C. |
| Title |
Light exposure in the natural environment: relevance to mood and sleep disorders |
Type |
Journal Article |
| Year |
2007 |
Publication |
Sleep Medicine |
Abbreviated Journal |
Sleep Med |
| Volume |
8 |
Issue |
6 |
Pages |
557-565 |
| Keywords |
Human Health; Affect; *Biological Clocks; *Circadian Rhythm; Humans; *Light; Mood Disorders/*etiology; Sleep Disorders, Circadian Rhythm/*complications; Wakefulness; Work Schedule Tolerance |
| Abstract |
In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at night. A misalignment between the endogenous circadian clock and the desired sleep schedule is the main cause of circadian sleep disorders; it may be involved in certain mood disorders as well. Since light is the main environmental cue used by the biological clock to set its own timing in relation to the day-night cycle, inappropriate light exposure can be involved in the physiopathology of circadian disorders. Conversely, when handled properly, controlled light exposure can be used to treat some mood and sleep disorders. While the earliest studies in the field focused solely on exposure to bright light, contemporary studies aim at understanding how the entire profile of light-dark exposure can influence the circadian clock and, consequently, mood, sleep, and vigilance quality. Following a brief summary of the main concepts underlying the non-visual effects of light, this paper presents some studies using ambulatory measurements of light exposure to illustrate how these concepts apply in real-life situations and discusses the clinical relevance of light exposure in the natural environment for mood, sleep, and circadian disorders. |
| Address |
Chronobiology Laboratory, Sacre-Coeur Hospital of Montreal, Montreal, Quebec, Canada H4J 1C5. marie.dumont@umontreal.ca |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1389-9457 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:17383230 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
736 |
| Permanent link to this record |
| |
|
| |
| Author |
Skene, D.J.; Arendt, J. |
| Title |
Circadian rhythm sleep disorders in the blind and their treatment with melatonin |
Type |
Journal Article |
| Year |
2007 |
Publication |
Sleep Medicine |
Abbreviated Journal |
Sleep Med |
| Volume |
8 |
Issue |
6 |
Pages |
651-655 |
| Keywords |
Human Health; Blindness/*complications; Chronotherapy; Circadian Rhythm/drug effects; Humans; Melatonin/*administration & dosage; Sleep/drug effects; Sleep Disorders, Circadian Rhythm/*drug therapy/*etiology; Treatment Outcome |
| Abstract |
People who are blind, in addition to having to cope with partial or no sight, have an added handicap; the transmission of ocular light from the retina to their circadian clock is impaired. At its worse, for example in people with both eyes enucleated, this lesion results in desynchronisation of the biological clock (located in the hypothalamic suprachiasmatic nuclei) from the 24h day/night environment. While in a desynchronised state, symptoms akin to jet lag are experienced (e.g., daytime sleepiness, poor night sleep, reduced alertness and performance during waking). This is a lifelong condition. Daily administration of exogenous melatonin is the current treatment of choice for this so-called “non-24h sleep/wake disorder”. Melatonin has been shown to correct the underlying circadian rhythm abnormality as well as improve sleep and reduce daytime napping. The effectiveness of melatonin therapy depends upon its time of administration relative to the timing of the person's circadian clock. If practicable, assessment of an individual's circadian phase (by measurement of the endogenous melatonin rhythm in plasma, saliva or urine) is recommended prior to commencing treatment to optimise melatonin's effectiveness. |
| Address |
Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK. d.skene@surrey.ac.uk |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1389-9457 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:17420154 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
811 |
| Permanent link to this record |
| |
|
| |
| Author |
Joo, E.Y.; Abbott, S.M.; Reid, K.J.; Wu, D.; Kang, J.; Wilson, J.; Zee, P.C. |
| Title |
Timing of light exposure and activity in adults with delayed sleep-wake phase disorder |
Type |
Journal Article |
| Year |
2016 |
Publication |
Sleep Medicine |
Abbreviated Journal |
Sleep Med |
| Volume |
32 |
Issue |
|
Pages |
259-265 |
| Keywords |
Human Health |
| Abstract |
OBJECTIVE: To characterize the patterns of light exposure and physical activity level and assess their relationship with sleep quality and depressive symptoms in adults with delayed sleep-wake phase disorder (DSWPD). METHODS: 42 DSWPD (22 female, mean age 34.5 y) and 26 (+/-4 years) age-and-sex-matched controls (12 female, mean age 33.4 y) underwent seven days of light and activity monitoring. RESULTS: Individuals with DSWPD had significantly delayed bed times and wake times, but similar sleep duration compared to controls. Subjective sleep quality (Pittsburgh Sleep Quality Index (PSQI)) was poorer in DSWPDs compared to controls. Those with DSWPD had significantly more activity and light exposure late at night (2:00-4:00) and significantly less activity and light exposure in the morning (8:00-11:00). Total 24 h levels of light and activity were not significantly different between DSWPD and controls. However, the DSWPD group had significantly more light exposure than controls 22 h after waking, during their sleep period. Later light exposure correlated with higher depression scores [Beck Depression Index (BDI)] and poorer sleep quality (PSQI). CONCLUSIONS: The light exposure patterns observed in DSWPD likely contribute to and perpetuate the chronically delayed sleep and wake phase in these patients. In addition, increased light exposure during the sleep period may also contribute to the poor sleep quality and mood disorders that are common in these individuals. |
| Address |
Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address: p-zee@northwestern.edu |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1389-9457 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:27964860 |
Approved |
no |
| Call Number |
LoNNe @ kyba @ |
Serial |
1639 |
| Permanent link to this record |
| |
|
| |
| Author |
Haus, E.L.; Smolensky, M.H. |
| Title |
Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation |
Type |
Journal Article |
| Year |
2013 |
Publication |
Sleep Medicine Reviews |
Abbreviated Journal |
Sleep Med Rev |
| Volume |
17 |
Issue |
4 |
Pages |
273-284 |
| Keywords |
Cell Cycle/physiology; Circadian Rhythm/*physiology; Epigenesis, Genetic/physiology; Humans; Light; Melatonin/physiology; Neoplasms/*etiology; Risk Factors; Sleep Deprivation/*complications; Work Schedule Tolerance/*physiology; oncogenesis |
| Abstract |
Shift work that includes a nighttime rotation has become an unavoidable attribute of today's 24-h society. The related disruption of the human circadian time organization leads in the short-term to an array of jet-lag-like symptoms, and in the long-run it may contribute to weight gain/obesity, metabolic syndrome/type II diabetes, and cardiovascular disease. Epidemiologic studies also suggest increased cancer risk, especially for breast cancer, in night and rotating female shift workers. If confirmed in more controlled and detailed studies, the carcinogenic effect of night and shift work will constitute additional serious medical, economic, and social problems for a substantial proportion of the working population. Here, we examine the possible multiple and interconnected cancer-promoting mechanisms as a consequence of shift work, i.e., repeated disruption of the circadian system, pineal hormone melatonin suppression by exposure to light at night, sleep-deprivation-caused impairment of the immune system, plus metabolic changes favoring obesity and generation of proinflammatory reactive oxygen species. |
| Address |
Department of Laboratory Medicine & Pathology, University of Minnesota and Health Partners Medical Group, Regions Hospital, 640 Jackson Street, St. Paul, Minnesota 55101, USA. Erhard.X.Haus@HealthPartners.com |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1087-0792 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:23137527 |
Approved |
no |
| Call Number |
IDA @ john @ |
Serial |
157 |
| Permanent link to this record |
