| Records |
| Author |
Wams, E.J.; Woelders, T.; Marring, I.; van Rosmalen, L.; Beersma, D.G.M.; Gordijn, M.C.M.; Hut, R.A. |
| Title |
Linking Light Exposure and Subsequent Sleep: A Field Polysomnography Study in Humans |
Type |
Journal Article |
| Year |
2017 |
Publication |
Sleep |
Abbreviated Journal |
Sleep |
| Volume |
40 |
Issue |
12 |
Pages |
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| Keywords |
actigraphy; chronobiology; circadian rhythms; scoring; sleep/wake mechanisms |
Abstract  |
Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory polysomnography (PSG) and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing, and architecture. Laboratory salivary dim-light melatonin onset was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2 = 0.34, chi2(1) = 7.19, p < .01), later light exposure (quadratic, controlling for daylength, R2 = 0.47, chi2(3) = 32.38, p < .0001), and to later sleep timing (R2 = 0.71, chi2(1) = 20.39, p < .0001). Those with later first exposure to more than 10 lux of light had more awakenings during subsequent sleep (controlled for daylength, R2 = 0.36, chi2(2) = 8.66, p < .05). Those with later light exposure subsequently had a shorter latency to first rapid eye movement (REM) sleep episode (R2 = 0.21, chi2(1) = 5.77, p < .05). Those with less light exposure subsequently had a higher percentage of REM sleep (R2 = 0.43, chi2(2) = 13.90, p < .001) in a clock phase modulated manner. Slow-wave sleep accumulation was observed to be larger after preceding exposure to high maximal intensity and early first light exposure (p < .05). Conclusions: The quality and architecture of sleep is associated with preceding light exposure. We propose that light exposure timing and intensity do not only modulate circadian-driven aspects of sleep but also homeostatic sleep pressure. These novel ambulatory PSG findings are the first to highlight the direct relationship between light and subsequent sleep, combining knowledge of homeostatic and circadian regulation of sleep by light. Upon confirmation by interventional studies, this hypothesis could change current understanding of sleep regulation and its relationship to prior light exposure. Clinical trial details: This study was not a clinical trial. The study was ethically approved and nationally registered (NL48468.042.14). |
| Address |
Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands |
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English |
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0161-8105 |
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| Notes |
PMID:29040758; PMCID:PMC5806586 |
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no |
| Call Number |
GFZ @ kyba @ |
Serial |
1885 |
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Peixoto, C.A.T.; da Silva, A.G.T.; Carskadon, M.A.; Louzada, F.M. |
| Title |
Adolescents living in homes without electric lighting have earlier sleep times |
Type |
Journal Article |
| Year |
2009 |
Publication |
Behavioral Sleep Medicine |
Abbreviated Journal |
Behav Sleep Med |
| Volume |
7 |
Issue |
2 |
Pages |
73-80 |
| Keywords |
Human Health; Sleep |
| Abstract |
The aim of this project was to compare circadian rhythmicity of a group of 37 adolescents (14 girls), aged 11 to 16 (mean age = 13.1 +/- 1.7 years), with and without electricity at home. Twenty students attended morning school (07:30-11:30), and 17 attended evening school classes (19:00-22:30). Eleven adolescents had no electric lighting at home (5 attended morning classes and 6 attended evening classes). They completed a sleep log and wore a wrist actigraph for 5 consecutive days. Saliva samples were collected to assess DLMO. Data were compared by ANOVA and showed later timing and a more extended sleep period for those who attended late classes. Those adolescents without electricity at home had significantly earlier sleep onset on school days. As to DLMO, a trend to a delay was observed in the groups who had electric lighting. |
| Address |
Department of Physiology, Universidade Federal do Parana, Brazil. pedatardelli@yahoo.com.br |
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English |
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1540-2002 |
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PMID:19330580 |
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no |
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LoNNe @ kyba @ |
Serial |
1481 |
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Komada, Y.; Aoki, K.; Gohshi, S.; Ichioka, H.; Shibata, S. |
| Title |
Effects of television luminance and wavelength at habitual bedtime on melatonin and cortisol secretion in humans: Blue light and melatonin secretion |
Type |
Journal Article |
| Year |
2015 |
Publication |
Sleep and Biological Rhythms |
Abbreviated Journal |
Sleep and Biological Rhythms |
| Volume |
13 |
Issue |
4 |
Pages |
316–322 |
| Keywords |
Human Health |
| Abstract |
The aim of this study was to examine the effect of exposure to different types of television displays at habitual bedtime on human melatonin and cortisol secretion. Thirteen male participants (mean age: 22.7 ± 0.85 years) were tested over three nights in one baseline and two experimental sessions. Participants were instructed to watch a movie on four different luminance- and wavelength-controlled television displays: normal luminance (450 candela [cd]/m2) or high luminance (1200 cd/m2) and normal blue light or half blue light. Salivary melatonin and cortisol levels were measured at two time points before and after television viewing. There was no significant difference in cortisol secretion due to the different displays. Melatonin suppression was significantly lower following the exposure to the half-blue light display compared with the normal blue light display. These results suggest that the use of half-blue light displays during night time may prevent circadian rhythm dysfunction. |
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1446-9235 |
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no |
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LoNNe @ christopher.kyba @ |
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1149 |
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Walbeek, T.J.; Harrison, E.M.; Soler, R.R.; Gorman, M.R. |
| Title |
Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules |
Type |
Journal Article |
| Year |
2019 |
Publication |
Clocks & Sleep |
Abbreviated Journal |
Clocks & Sleep |
| Volume |
1 |
Issue |
3 |
Pages |
394-413 |
| Keywords |
Animals |
| Abstract |
The circadian system is generally considered to be incapable of adjusting to rapid changes in sleep/work demands. In shiftworkers this leads to chronic circadian disruption and sleep loss, which together predict underperformance at work and negative health consequences. Two distinct experimental protocols have been proposed to increase circadian flexibility in rodents using dim light at night: rhythm bifurcation and T-cycle (i.e., day length) entrainment. Successful translation of such protocols to human shiftworkers could facilitate alignment of internal time with external demands. To assess entrainment flexibility following bifurcation and exposure to T-cycles, mice in Study 1 were repeatedly phase-shifted. Mice from experimental conditions rapidly phase-shifted their activity, while control mice showed expected transient misalignment. In Study 2 and 3, mice followed a several weeks-long intervention designed to model a modified DuPont or Continental shiftwork schedule, respectively. For both schedules, bifurcation and nocturnal dim lighting reduced circadian misalignment. Together, these studies demonstrate proof of concept that mammalian circadian systems can be rendered sufficiently flexible to adapt to multiple, rapidly changing shiftwork schedules. Flexible adaptation to exotic light-dark cycles likely relies on entrainment mechanisms that are distinct from traditional entrainment. |
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2624-5175 |
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no |
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GFZ @ kyba @ |
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2661 |
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Sletten, T.L.; Cappuccio, F.P.; Davidson, A.J.; Van Cauter, E.; Rajaratnam, S.M.W.; Scheer, F.A.J.L. |
| Title |
Health consequences of circadian disruption |
Type |
Journal Article |
| Year |
2020 |
Publication |
Sleep |
Abbreviated Journal |
Sleep |
| Volume |
43 |
Issue |
1 |
Pages |
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| Keywords |
Human Health; Circadian Rhythm; Chronobiology; Sleep; Review |
| Abstract |
The circadian system is key for optimal functioning by maintaining synchrony between internal circadian rhythms, behaviors, and external cues. Many clinicians are not fully aware, however, of the far-reaching implications of the circadian system for human health. Clinical attention to circadian rhythms has largely focused on sleep disturbances. The impact of the circadian system on health is, however, much broader. Clinical diagnoses are often based on single time point assessments during the day, ignoring circadian influences on physiology. Even when time is considered, using (external) clock time ignores the large interindividual differences in internal timing. |
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Division of Sleep Medicine, Harvard Medical School, Boston, MA |
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English |
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0161-8105 |
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PMID:31930347 |
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no |
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IDA @ john @ |
Serial |
2822 |
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