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Author Kessel, L.; Siganos, G.; Jorgensen, T.; Larsen, M. url  doi
openurl 
  Title Sleep disturbances are related to decreased transmission of blue light to the retina caused by lens yellowing Type Journal Article
  Year 2011 Publication Sleep Abbreviated Journal Sleep  
  Volume 34 Issue 9 Pages 1215-1219  
  Keywords Adult; Age Factors; Aging/*pathology/physiology; Circadian Rhythm/physiology; Cross-Sectional Studies; Female; Fluorometry; Humans; Lens, Crystalline/*pathology/physiopathology; *Light; Male; Middle Aged; Retina/*physiopathology; Risk Factors; *Scattering, Radiation; Sleep Disorders/*etiology; Circadian rhythm; cataract; melanopsin; sleep; blue light  
  Abstract (up) STUDY OBJECTIVES: Sleep pattern and circadian rhythms are regulated via the retinohypothalamic tract in response to stimulation of a subset of retinal ganglion cells, predominantly by blue light (450-490 nm). With age, the transmission of blue light to the retina is reduced because of the aging process of the human lens, and this may impair the photoentrainment of circadian rhythm leading to sleep disorders. The aim of the study was to examine the association between lens aging and sleep disorders. DESIGN: Cross-sectional population based study. SETTING: The study was performed at the Research Center for Prevention and Health, Glostrup Hospital, Denmark and at the Department of Ophthalmology, Herlev Hospital, Denmark. PARTICIPANTS: An age- and sex-stratified sample of 970 persons aged 30 to 60 years of age drawn from a sample randomly selected from the background population. INTERVENTIONS: Not applicable. MEASUREMENTS AND RESULTS: Sleep disturbances were evaluated by a combination of questionnaire and the use of prescription sleeping medication. Lens aging (transmission and yellowing) was measured objectively by lens autofluorometry. The risk of sleep disturbances was significantly increased when the transmission of blue light to the retina was low, even after correction for the effect of age and other confounding factors such as smoking habits, diabetes mellitus, gender, and the risk of ischemic heart disease (P < 0.0001). CONCLUSIONS: Filtration of blue light by the aging lens was significantly associated with an increased risk of sleep disturbances. We propose that this is a result of disturbance of photoentrainment of circadian rhythms.  
  Address Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark. line.kessel@dadlnet.dk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21886359; PMCID:PMC3157663 Approved no  
  Call Number IDA @ john @ Serial 344  
Permanent link to this record
 

 
Author Wams, E.J.; Woelders, T.; Marring, I.; van Rosmalen, L.; Beersma, D.G.M.; Gordijn, M.C.M.; Hut, R.A. url  doi
openurl 
  Title Linking Light Exposure and Subsequent Sleep: A Field Polysomnography Study in Humans Type Journal Article
  Year 2017 Publication Sleep Abbreviated Journal Sleep  
  Volume 40 Issue 12 Pages  
  Keywords actigraphy; chronobiology; circadian rhythms; scoring; sleep/wake mechanisms  
  Abstract (up) Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory polysomnography (PSG) and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing, and architecture. Laboratory salivary dim-light melatonin onset was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2 = 0.34, chi2(1) = 7.19, p < .01), later light exposure (quadratic, controlling for daylength, R2 = 0.47, chi2(3) = 32.38, p < .0001), and to later sleep timing (R2 = 0.71, chi2(1) = 20.39, p < .0001). Those with later first exposure to more than 10 lux of light had more awakenings during subsequent sleep (controlled for daylength, R2 = 0.36, chi2(2) = 8.66, p < .05). Those with later light exposure subsequently had a shorter latency to first rapid eye movement (REM) sleep episode (R2 = 0.21, chi2(1) = 5.77, p < .05). Those with less light exposure subsequently had a higher percentage of REM sleep (R2 = 0.43, chi2(2) = 13.90, p < .001) in a clock phase modulated manner. Slow-wave sleep accumulation was observed to be larger after preceding exposure to high maximal intensity and early first light exposure (p < .05). Conclusions: The quality and architecture of sleep is associated with preceding light exposure. We propose that light exposure timing and intensity do not only modulate circadian-driven aspects of sleep but also homeostatic sleep pressure. These novel ambulatory PSG findings are the first to highlight the direct relationship between light and subsequent sleep, combining knowledge of homeostatic and circadian regulation of sleep by light. Upon confirmation by interventional studies, this hypothesis could change current understanding of sleep regulation and its relationship to prior light exposure. Clinical trial details: This study was not a clinical trial. The study was ethically approved and nationally registered (NL48468.042.14).  
  Address Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29040758; PMCID:PMC5806586 Approved no  
  Call Number GFZ @ kyba @ Serial 1885  
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Author Peixoto, C.A.T.; da Silva, A.G.T.; Carskadon, M.A.; Louzada, F.M. url  doi
openurl 
  Title Adolescents living in homes without electric lighting have earlier sleep times Type Journal Article
  Year 2009 Publication Behavioral Sleep Medicine Abbreviated Journal Behav Sleep Med  
  Volume 7 Issue 2 Pages 73-80  
  Keywords Human Health; Sleep  
  Abstract (up) The aim of this project was to compare circadian rhythmicity of a group of 37 adolescents (14 girls), aged 11 to 16 (mean age = 13.1 +/- 1.7 years), with and without electricity at home. Twenty students attended morning school (07:30-11:30), and 17 attended evening school classes (19:00-22:30). Eleven adolescents had no electric lighting at home (5 attended morning classes and 6 attended evening classes). They completed a sleep log and wore a wrist actigraph for 5 consecutive days. Saliva samples were collected to assess DLMO. Data were compared by ANOVA and showed later timing and a more extended sleep period for those who attended late classes. Those adolescents without electricity at home had significantly earlier sleep onset on school days. As to DLMO, a trend to a delay was observed in the groups who had electric lighting.  
  Address Department of Physiology, Universidade Federal do Parana, Brazil. pedatardelli@yahoo.com.br  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1540-2002 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19330580 Approved no  
  Call Number LoNNe @ kyba @ Serial 1481  
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Author Komada, Y.; Aoki, K.; Gohshi, S.; Ichioka, H.; Shibata, S. url  doi
openurl 
  Title Effects of television luminance and wavelength at habitual bedtime on melatonin and cortisol secretion in humans: Blue light and melatonin secretion Type Journal Article
  Year 2015 Publication Sleep and Biological Rhythms Abbreviated Journal Sleep and Biological Rhythms  
  Volume 13 Issue 4 Pages 316–322  
  Keywords Human Health  
  Abstract (up) The aim of this study was to examine the effect of exposure to different types of television displays at habitual bedtime on human melatonin and cortisol secretion. Thirteen male participants (mean age: 22.7 ± 0.85 years) were tested over three nights in one baseline and two experimental sessions. Participants were instructed to watch a movie on four different luminance- and wavelength-controlled television displays: normal luminance (450 candela [cd]/m2) or high luminance (1200&#8201;cd/m2) and normal blue light or half blue light. Salivary melatonin and cortisol levels were measured at two time points before and after television viewing. There was no significant difference in cortisol secretion due to the different displays. Melatonin suppression was significantly lower following the exposure to the half-blue light display compared with the normal blue light display. These results suggest that the use of half-blue light displays during night time may prevent circadian rhythm dysfunction.  
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  Series Volume Series Issue Edition  
  ISSN 1446-9235 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1149  
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Author Walbeek, T.J.; Harrison, E.M.; Soler, R.R.; Gorman, M.R. url  doi
openurl 
  Title Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules Type Journal Article
  Year 2019 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 1 Issue 3 Pages 394-413  
  Keywords Animals  
  Abstract (up) The circadian system is generally considered to be incapable of adjusting to rapid changes in sleep/work demands. In shiftworkers this leads to chronic circadian disruption and sleep loss, which together predict underperformance at work and negative health consequences. Two distinct experimental protocols have been proposed to increase circadian flexibility in rodents using dim light at night: rhythm bifurcation and T-cycle (i.e., day length) entrainment. Successful translation of such protocols to human shiftworkers could facilitate alignment of internal time with external demands. To assess entrainment flexibility following bifurcation and exposure to T-cycles, mice in Study 1 were repeatedly phase-shifted. Mice from experimental conditions rapidly phase-shifted their activity, while control mice showed expected transient misalignment. In Study 2 and 3, mice followed a several weeks-long intervention designed to model a modified DuPont or Continental shiftwork schedule, respectively. For both schedules, bifurcation and nocturnal dim lighting reduced circadian misalignment. Together, these studies demonstrate proof of concept that mammalian circadian systems can be rendered sufficiently flexible to adapt to multiple, rapidly changing shiftwork schedules. Flexible adaptation to exotic light-dark cycles likely relies on entrainment mechanisms that are distinct from traditional entrainment.  
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  Series Volume Series Issue Edition  
  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2661  
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