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Author Dumont, M.; Beaulieu, C.
Title Light exposure in the natural environment: relevance to mood and sleep disorders Type Journal Article
Year 2007 Publication Sleep Medicine Abbreviated Journal Sleep Med
Volume 8 Issue 6 Pages 557-565
Keywords Human Health; Affect; *Biological Clocks; *Circadian Rhythm; Humans; *Light; Mood Disorders/*etiology; Sleep Disorders, Circadian Rhythm/*complications; Wakefulness; Work Schedule Tolerance
Abstract In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at night. A misalignment between the endogenous circadian clock and the desired sleep schedule is the main cause of circadian sleep disorders; it may be involved in certain mood disorders as well. Since light is the main environmental cue used by the biological clock to set its own timing in relation to the day-night cycle, inappropriate light exposure can be involved in the physiopathology of circadian disorders. Conversely, when handled properly, controlled light exposure can be used to treat some mood and sleep disorders. While the earliest studies in the field focused solely on exposure to bright light, contemporary studies aim at understanding how the entire profile of light-dark exposure can influence the circadian clock and, consequently, mood, sleep, and vigilance quality. Following a brief summary of the main concepts underlying the non-visual effects of light, this paper presents some studies using ambulatory measurements of light exposure to illustrate how these concepts apply in real-life situations and discusses the clinical relevance of light exposure in the natural environment for mood, sleep, and circadian disorders.
Address (up) Chronobiology Laboratory, Sacre-Coeur Hospital of Montreal, Montreal, Quebec, Canada H4J 1C5. marie.dumont@umontreal.ca
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1389-9457 ISBN Medium
Area Expedition Conference
Notes PMID:17383230 Approved no
Call Number LoNNe @ kagoburian @ Serial 736
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Author Wams, E.J.; Woelders, T.; Marring, I.; van Rosmalen, L.; Beersma, D.G.M.; Gordijn, M.C.M.; Hut, R.A.
Title Linking Light Exposure and Subsequent Sleep: A Field Polysomnography Study in Humans Type Journal Article
Year 2017 Publication Sleep Abbreviated Journal Sleep
Volume 40 Issue 12 Pages
Keywords actigraphy; chronobiology; circadian rhythms; scoring; sleep/wake mechanisms
Abstract Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory polysomnography (PSG) and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing, and architecture. Laboratory salivary dim-light melatonin onset was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2 = 0.34, chi2(1) = 7.19, p < .01), later light exposure (quadratic, controlling for daylength, R2 = 0.47, chi2(3) = 32.38, p < .0001), and to later sleep timing (R2 = 0.71, chi2(1) = 20.39, p < .0001). Those with later first exposure to more than 10 lux of light had more awakenings during subsequent sleep (controlled for daylength, R2 = 0.36, chi2(2) = 8.66, p < .05). Those with later light exposure subsequently had a shorter latency to first rapid eye movement (REM) sleep episode (R2 = 0.21, chi2(1) = 5.77, p < .05). Those with less light exposure subsequently had a higher percentage of REM sleep (R2 = 0.43, chi2(2) = 13.90, p < .001) in a clock phase modulated manner. Slow-wave sleep accumulation was observed to be larger after preceding exposure to high maximal intensity and early first light exposure (p < .05). Conclusions: The quality and architecture of sleep is associated with preceding light exposure. We propose that light exposure timing and intensity do not only modulate circadian-driven aspects of sleep but also homeostatic sleep pressure. These novel ambulatory PSG findings are the first to highlight the direct relationship between light and subsequent sleep, combining knowledge of homeostatic and circadian regulation of sleep by light. Upon confirmation by interventional studies, this hypothesis could change current understanding of sleep regulation and its relationship to prior light exposure. Clinical trial details: This study was not a clinical trial. The study was ethically approved and nationally registered (NL48468.042.14).
Address (up) Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0161-8105 ISBN Medium
Area Expedition Conference
Notes PMID:29040758; PMCID:PMC5806586 Approved no
Call Number GFZ @ kyba @ Serial 1885
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Author Escobar, C.; Salgado-Delgado, R.; Gonzalez-Guerra, E.; Tapia Osorio, A.; Angeles-Castellanos, M.; Buijs, R.M.
Title Circadian disruption leads to loss of homeostasis and disease Type Journal Article
Year 2011 Publication Sleep Disorders Abbreviated Journal Sleep Disord
Volume 2011 Issue Pages 964510
Keywords Human Health
Abstract The relevance of a synchronized temporal order for adaptation and homeostasis is discussed in this review. We present evidence suggesting that an altered temporal order between the biological clock and external temporal signals leads to disease. Evidence mainly based on a rodent model of “night work” using forced activity during the sleep phase suggests that altered activity and feeding schedules, out of phase from the light/dark cycle, may be the main cause for the loss of circadian synchrony and disease. It is proposed that by avoiding food intake during sleep hours the circadian misalignment and adverse consequences can be prevented. This review does not attempt to present a thorough revision of the literature, but instead it aims to highlight the association between circadian disruption and disease with special emphasis on the contribution of feeding schedules in circadian synchrony.
Address (up) Departamento de Anatomia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, 04360 Mexico City, DF, Mexico
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2090-3553 ISBN Medium
Area Expedition Conference
Notes PMID:23471148; PMCID:PMC3581131 Approved no
Call Number LoNNe @ kagoburian @ Serial 745
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Author Obayashi, K.; Yamagami, Y.; Kurumatani, N.; Saeki, K.
Title Bedroom lighting environment and incident diabetes mellitus: a longitudinal study of the HEIJO-KYO cohort Type Journal Article
Year 2019 Publication Sleep Medicine Abbreviated Journal Sleep Medicine
Volume 65 Issue Pages 1-3
Keywords Human Health; Metabolic disorders; diabetes; geriatrics
Abstract Objectives

Light information received by the brain influences human circadian timing and metabolism; low-level light at night (LAN) significantly increased body mass and led to prediabetes in mice. We hypothesized that LAN exposure increases the diabetes risk in humans. The aim of the present study was to evaluate a longitudinal association between LAN exposure and the incidence of diabetes in a general population.

Methods

In our prospective cohort study, bedroom light intensity was measured at 1-min intervals in 678 elderly participants without diabetes at baseline. The average light intensity recorded between bedtimes and rise times over two consecutive nights was used in the analysis.

Results

During follow-up (median, 42 months), 19 of the 678 participants (mean age, 70.6 years) developed diabetes. Poisson regression models revealed that the incidence rate for diabetes was significantly higher in the LAN group (average ≥5 lux, N = 128) than the dark group (average <5 lux, N = 550) (incidence rate ratio, 3.74; 95% confidence interval (CI), 1.55–9.05; p=0.003). Further propensity score adjustments in relation to LAN produced consistent results (incidence rate ratio, 3.19; 95% CI, 1.38–7.35; p=0.007). When the cut-off value of LAN was decreased to 3 lux, the relationship remained significant (incidence rate ratio 2.74; 95% CI, 1.19–6.33; p=0.018).

Conclusions

Our findings suggest that LAN exposure increases the incidence of diabetes in a general elderly population. Further research involving a large cohort with new-onset diabetes is warranted to elucidate these findings.
Address (up) Department of Epidemiology, Nara Medical University School of Medicine, 840 Shijocho, Kashiharashi, Nara, 634-8521, Japan; obayashi(at)naramed-u.ac.jp
Corporate Author Thesis
Publisher Elsevier Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1389-9457 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2605
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Author Haus, E.L.; Smolensky, M.H.
Title Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation Type Journal Article
Year 2013 Publication Sleep Medicine Reviews Abbreviated Journal Sleep Med Rev
Volume 17 Issue 4 Pages 273-284
Keywords Cell Cycle/physiology; Circadian Rhythm/*physiology; Epigenesis, Genetic/physiology; Humans; Light; Melatonin/physiology; Neoplasms/*etiology; Risk Factors; Sleep Deprivation/*complications; Work Schedule Tolerance/*physiology; oncogenesis
Abstract Shift work that includes a nighttime rotation has become an unavoidable attribute of today's 24-h society. The related disruption of the human circadian time organization leads in the short-term to an array of jet-lag-like symptoms, and in the long-run it may contribute to weight gain/obesity, metabolic syndrome/type II diabetes, and cardiovascular disease. Epidemiologic studies also suggest increased cancer risk, especially for breast cancer, in night and rotating female shift workers. If confirmed in more controlled and detailed studies, the carcinogenic effect of night and shift work will constitute additional serious medical, economic, and social problems for a substantial proportion of the working population. Here, we examine the possible multiple and interconnected cancer-promoting mechanisms as a consequence of shift work, i.e., repeated disruption of the circadian system, pineal hormone melatonin suppression by exposure to light at night, sleep-deprivation-caused impairment of the immune system, plus metabolic changes favoring obesity and generation of proinflammatory reactive oxygen species.
Address (up) Department of Laboratory Medicine & Pathology, University of Minnesota and Health Partners Medical Group, Regions Hospital, 640 Jackson Street, St. Paul, Minnesota 55101, USA. Erhard.X.Haus@HealthPartners.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1087-0792 ISBN Medium
Area Expedition Conference
Notes PMID:23137527 Approved no
Call Number IDA @ john @ Serial 157
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