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| Author | Wams, E.J.; Woelders, T.; Marring, I.; van Rosmalen, L.; Beersma, D.G.M.; Gordijn, M.C.M.; Hut, R.A. | ||||
| Title | Linking Light Exposure and Subsequent Sleep: A Field Polysomnography Study in Humans | Type | Journal Article | ||
| Year | 2017 | Publication | Sleep | Abbreviated Journal | Sleep |
| Volume | 40 | Issue | 12 | Pages  |
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| Keywords | actigraphy; chronobiology; circadian rhythms; scoring; sleep/wake mechanisms | ||||
| Abstract | Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory polysomnography (PSG) and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing, and architecture. Laboratory salivary dim-light melatonin onset was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2 = 0.34, chi2(1) = 7.19, p < .01), later light exposure (quadratic, controlling for daylength, R2 = 0.47, chi2(3) = 32.38, p < .0001), and to later sleep timing (R2 = 0.71, chi2(1) = 20.39, p < .0001). Those with later first exposure to more than 10 lux of light had more awakenings during subsequent sleep (controlled for daylength, R2 = 0.36, chi2(2) = 8.66, p < .05). Those with later light exposure subsequently had a shorter latency to first rapid eye movement (REM) sleep episode (R2 = 0.21, chi2(1) = 5.77, p < .05). Those with less light exposure subsequently had a higher percentage of REM sleep (R2 = 0.43, chi2(2) = 13.90, p < .001) in a clock phase modulated manner. Slow-wave sleep accumulation was observed to be larger after preceding exposure to high maximal intensity and early first light exposure (p < .05). Conclusions: The quality and architecture of sleep is associated with preceding light exposure. We propose that light exposure timing and intensity do not only modulate circadian-driven aspects of sleep but also homeostatic sleep pressure. These novel ambulatory PSG findings are the first to highlight the direct relationship between light and subsequent sleep, combining knowledge of homeostatic and circadian regulation of sleep by light. Upon confirmation by interventional studies, this hypothesis could change current understanding of sleep regulation and its relationship to prior light exposure. Clinical trial details: This study was not a clinical trial. The study was ethically approved and nationally registered (NL48468.042.14). | ||||
| Address | Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands | ||||
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| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:29040758; PMCID:PMC5806586 | Approved | no | ||
| Call Number | GFZ @ kyba @ | Serial | 1885 | ||
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| Author | Wilson IV, J.; Reid, K.J.; Braun, R.I.; Abbott, S.M.; Zee, P.C. | ||||
| Title | Habitual Light Exposure Relative to Circadian Timing in Delayed Sleep-Wake Phase Disorder | Type | Journal Article | ||
| Year | 2018 | Publication | Sleep | Abbreviated Journal | |
| Volume | in press | Issue | Pages |
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| Keywords | Human Health | ||||
| Abstract | Study Objectives To compare melatonin timing, a well validated marker for endogenous circadian phase, and habitual light exposure patterns in adults with delayed sleep-wake phase disorder (DSWPD) and intermediate chronotype controls. Methods 12 individuals with DSWPD (5 females, mean age 31.1) and 12 age matched controls (6 females, mean age 33.6) underwent a minimum of seven days of light and activity monitoring followed by an inpatient hospital stay, where blood was taken to assess melatonin timing (calculated as dim light melatonin onset – DLMO). Habitual light exposure patterns were then compared to a human phase response curve (PRC) to light. Results Relative to clock time, individuals with DSWPD had a later light exposure pattern compared to controls, but their light exposure pattern was earlier relative to DLMO. According to the human phase response curve (PRC) to light, individuals with DSWPD had less daily advancing light exposure compared to controls. The primary difference was seen in the late portion of the advancing window, in which individuals with DSWPD were exposed to fewer pulses of light of equivalent duration and intensity compared to controls. Conclusions Diminished advancing light exposure may play a role in the development and perpetuation of delayed sleep-wake timing in individuals with DSWPD. Enhancing light exposure during the later portion of the advancing window represents an innovative and complementary strategy that has the potential to improve the effectiveness of bright light therapy in DSWPD. |
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| Language | Summary Language | Original Title | |||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | GFZ @ kyba @ | Serial | 1990 | ||
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| Author | Sletten, T.L.; Cappuccio, F.P.; Davidson, A.J.; Van Cauter, E.; Rajaratnam, S.M.W.; Scheer, F.A.J.L. | ||||
| Title | Health consequences of circadian disruption | Type | Journal Article | ||
| Year | 2020 | Publication | Sleep | Abbreviated Journal | Sleep |
| Volume | 43 | Issue | 1 | Pages |
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| Keywords | Human Health; Circadian Rhythm; Chronobiology; Sleep; Review | ||||
| Abstract | The circadian system is key for optimal functioning by maintaining synchrony between internal circadian rhythms, behaviors, and external cues. Many clinicians are not fully aware, however, of the far-reaching implications of the circadian system for human health. Clinical attention to circadian rhythms has largely focused on sleep disturbances. The impact of the circadian system on health is, however, much broader. Clinical diagnoses are often based on single time point assessments during the day, ignoring circadian influences on physiology. Even when time is considered, using (external) clock time ignores the large interindividual differences in internal timing. | ||||
| Address | Division of Sleep Medicine, Harvard Medical School, Boston, MA | ||||
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| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:31930347 | Approved | no | ||
| Call Number | IDA @ john @ | Serial | 2822 | ||
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