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Author | Savarese, M.; Di Perri, M.C. | ||||
Title | Excessive sleepiness in shift work disorder: a narrative review of the last 5 years | Type | Journal Article | ||
Year | 2019 | Publication | Sleep & Breathing = Schlaf & Atmung | Abbreviated Journal | Sleep Breath |
Volume | Issue | Pages ![]() |
1-14 | ||
Keywords | Human Health; Alertness; Armodafinil; Insomnia; Performance; Shift work disorder; excessive sleepiness; StimulaCentral Nervous System Stimulants; Review | ||||
Abstract | INTRODUCTION: Shift work sleep disorder (SWSD), also known as shift work disorder (SWD), is a circadian rhythm sleep disorder characterized by insomnia and/or excessive sleepiness, associated with a recurring work schedule that overlaps the usual time designated for sleeping. PURPOSE: This article aims to provide a narrative review of the pharmacological trials conducted on SWD in the last 5 years, to better address safety and health issues inherent to this disorder. METHODS: An electronic literature search was conducted using PubMed. All eligible randomized controlled trials (RCTs) and cross-over RCTs with employees undertaking shift work (including night shifts) were considered, yielding three articles. RESULTS: All three studies showed the efficacy of armodafinil in improving subjective and objective sleepiness, clinical conditions, and global functioning regardless of shift duration. Both performance and driving simulator performance tests administered during the night shift bore better results following armodafinil administration than after placebo. However, armodafinil only reduced subjective disability in individuals working more than 9 h; furthermore, even after armodafinil, alertness was reduced but not normalized. CONCLUSION: These studies underscore the importance of preventing and/or minimizing disturbances due to shift work. This may be achieved through various strategies, such as the employer's commitment to adopt ergonomic criteria in shift design and to implement work-environment interventions like controlled bright light. Health personnel is of pivotal importance to detect potential factors of intolerance to shift work or early symptoms of SWD. Additional and improved studies are needed to further evaluate the effectiveness and safety of both pharmacological and non-pharmacological interventions. | ||||
Address | Center of Sleep Medicine, UOSD of Neurophysiopathology and Disorders of Movement, AOU G Martino, Department of Clinical and Experimental Medicine, University of Messina, 98121, Messina, Italy. mdiperri@wesleyan.edu | ||||
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Language | English | Summary Language | Original Title | ||
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ISSN | 1520-9512 | ISBN | Medium | ||
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Notes | PMID:31471831 | Approved | no | ||
Call Number | GFZ @ kyba @ | Serial | 2662 | ||
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Author | Paul, M.A.; Love, R.J.; Hawton, A.; Brett, K.; McCreary, D.R.; Arendt, J. | ||||
Title | Sleep deficits in the high Arctic summer in relation to light exposure and behaviour: use of melatonin as a countermeasure | Type | Journal Article | ||
Year | 2015 | Publication | Sleep Medicine | Abbreviated Journal | Sleep Medicine |
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Keywords | Human Health; Sleep | ||||
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ISSN | 1389-9457 | ISBN | Medium | ||
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Notes | Approved | no | |||
Call Number | LoNNe @ christopher.kyba @ | Serial | 1093 | ||
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Author | WDS Killgore | ||||
Title | Lighting the Way to Better Sleep and Health | Type | Journal Article | ||
Year | 2016 | Publication | Journal of Sleep Disorders: Treatment and Care | Abbreviated Journal | J Sleep Disor: Treat Care |
Volume | 05 | Issue | 01 | Pages ![]() |
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Keywords | Health; Editorial | ||||
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ISSN | 2325-9639 | ISBN | Medium | ||
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Notes | Approved | no | |||
Call Number | LoNNe @ kyba @ | Serial | 1442 | ||
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Author | Wams, E.J.; Woelders, T.; Marring, I.; van Rosmalen, L.; Beersma, D.G.M.; Gordijn, M.C.M.; Hut, R.A. | ||||
Title | Linking Light Exposure and Subsequent Sleep: A Field Polysomnography Study in Humans | Type | Journal Article | ||
Year | 2017 | Publication | Sleep | Abbreviated Journal | Sleep |
Volume | 40 | Issue | 12 | Pages ![]() |
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Keywords | actigraphy; chronobiology; circadian rhythms; scoring; sleep/wake mechanisms | ||||
Abstract | Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory polysomnography (PSG) and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing, and architecture. Laboratory salivary dim-light melatonin onset was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2 = 0.34, chi2(1) = 7.19, p < .01), later light exposure (quadratic, controlling for daylength, R2 = 0.47, chi2(3) = 32.38, p < .0001), and to later sleep timing (R2 = 0.71, chi2(1) = 20.39, p < .0001). Those with later first exposure to more than 10 lux of light had more awakenings during subsequent sleep (controlled for daylength, R2 = 0.36, chi2(2) = 8.66, p < .05). Those with later light exposure subsequently had a shorter latency to first rapid eye movement (REM) sleep episode (R2 = 0.21, chi2(1) = 5.77, p < .05). Those with less light exposure subsequently had a higher percentage of REM sleep (R2 = 0.43, chi2(2) = 13.90, p < .001) in a clock phase modulated manner. Slow-wave sleep accumulation was observed to be larger after preceding exposure to high maximal intensity and early first light exposure (p < .05). Conclusions: The quality and architecture of sleep is associated with preceding light exposure. We propose that light exposure timing and intensity do not only modulate circadian-driven aspects of sleep but also homeostatic sleep pressure. These novel ambulatory PSG findings are the first to highlight the direct relationship between light and subsequent sleep, combining knowledge of homeostatic and circadian regulation of sleep by light. Upon confirmation by interventional studies, this hypothesis could change current understanding of sleep regulation and its relationship to prior light exposure. Clinical trial details: This study was not a clinical trial. The study was ethically approved and nationally registered (NL48468.042.14). | ||||
Address | Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands | ||||
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Language | English | Summary Language | Original Title | ||
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ISSN | 0161-8105 | ISBN | Medium | ||
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Notes | PMID:29040758; PMCID:PMC5806586 | Approved | no | ||
Call Number | GFZ @ kyba @ | Serial | 1885 | ||
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Author | Wilson IV, J.; Reid, K.J.; Braun, R.I.; Abbott, S.M.; Zee, P.C. | ||||
Title | Habitual Light Exposure Relative to Circadian Timing in Delayed Sleep-Wake Phase Disorder | Type | Journal Article | ||
Year | 2018 | Publication | Sleep | Abbreviated Journal | |
Volume | in press | Issue | Pages ![]() |
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Keywords | Human Health | ||||
Abstract | Study Objectives To compare melatonin timing, a well validated marker for endogenous circadian phase, and habitual light exposure patterns in adults with delayed sleep-wake phase disorder (DSWPD) and intermediate chronotype controls. Methods 12 individuals with DSWPD (5 females, mean age 31.1) and 12 age matched controls (6 females, mean age 33.6) underwent a minimum of seven days of light and activity monitoring followed by an inpatient hospital stay, where blood was taken to assess melatonin timing (calculated as dim light melatonin onset – DLMO). Habitual light exposure patterns were then compared to a human phase response curve (PRC) to light. Results Relative to clock time, individuals with DSWPD had a later light exposure pattern compared to controls, but their light exposure pattern was earlier relative to DLMO. According to the human phase response curve (PRC) to light, individuals with DSWPD had less daily advancing light exposure compared to controls. The primary difference was seen in the late portion of the advancing window, in which individuals with DSWPD were exposed to fewer pulses of light of equivalent duration and intensity compared to controls. Conclusions Diminished advancing light exposure may play a role in the development and perpetuation of delayed sleep-wake timing in individuals with DSWPD. Enhancing light exposure during the later portion of the advancing window represents an innovative and complementary strategy that has the potential to improve the effectiveness of bright light therapy in DSWPD. |
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ISSN | 0161-8105 | ISBN | Medium | ||
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Notes | Approved | no | |||
Call Number | GFZ @ kyba @ | Serial | 1990 | ||
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