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| Author | Wams, E.J.; Woelders, T.; Marring, I.; van Rosmalen, L.; Beersma, D.G.M.; Gordijn, M.C.M.; Hut, R.A. | ||||
| Title | Linking Light Exposure and Subsequent Sleep: A Field Polysomnography Study in Humans | Type | Journal Article | ||
| Year | 2017 | Publication | Sleep | Abbreviated Journal | Sleep |
| Volume | 40 | Issue | 12 | Pages | |
| Keywords | actigraphy; chronobiology; circadian rhythms; scoring; sleep/wake mechanisms | ||||
| Abstract | Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory polysomnography (PSG) and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing, and architecture. Laboratory salivary dim-light melatonin onset was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2 = 0.34, chi2(1) = 7.19, p < .01), later light exposure (quadratic, controlling for daylength, R2 = 0.47, chi2(3) = 32.38, p < .0001), and to later sleep timing (R2 = 0.71, chi2(1) = 20.39, p < .0001). Those with later first exposure to more than 10 lux of light had more awakenings during subsequent sleep (controlled for daylength, R2 = 0.36, chi2(2) = 8.66, p < .05). Those with later light exposure subsequently had a shorter latency to first rapid eye movement (REM) sleep episode (R2 = 0.21, chi2(1) = 5.77, p < .05). Those with less light exposure subsequently had a higher percentage of REM sleep (R2 = 0.43, chi2(2) = 13.90, p < .001) in a clock phase modulated manner. Slow-wave sleep accumulation was observed to be larger after preceding exposure to high maximal intensity and early first light exposure (p < .05). Conclusions: The quality and architecture of sleep is associated with preceding light exposure. We propose that light exposure timing and intensity do not only modulate circadian-driven aspects of sleep but also homeostatic sleep pressure. These novel ambulatory PSG findings are the first to highlight the direct relationship between light and subsequent sleep, combining knowledge of homeostatic and circadian regulation of sleep by light. Upon confirmation by interventional studies, this hypothesis could change current understanding of sleep regulation and its relationship to prior light exposure. Clinical trial details: This study was not a clinical trial. The study was ethically approved and nationally registered (NL48468.042.14). | ||||
| Address | Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands | ||||
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| Language | English | Summary Language | Original Title | ||
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0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:29040758; PMCID:PMC5806586 | Approved | no | ||
| Call Number | GFZ @ kyba @ | Serial | 1885 | ||
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| Author | Wilson IV, J.; Reid, K.J.; Braun, R.I.; Abbott, S.M.; Zee, P.C. | ||||
| Title | Habitual Light Exposure Relative to Circadian Timing in Delayed Sleep-Wake Phase Disorder | Type | Journal Article | ||
| Year | 2018 | Publication | Sleep | Abbreviated Journal | |
| Volume | in press | Issue | Pages | ||
| Keywords | Human Health | ||||
| Abstract | Study Objectives To compare melatonin timing, a well validated marker for endogenous circadian phase, and habitual light exposure patterns in adults with delayed sleep-wake phase disorder (DSWPD) and intermediate chronotype controls. Methods 12 individuals with DSWPD (5 females, mean age 31.1) and 12 age matched controls (6 females, mean age 33.6) underwent a minimum of seven days of light and activity monitoring followed by an inpatient hospital stay, where blood was taken to assess melatonin timing (calculated as dim light melatonin onset – DLMO). Habitual light exposure patterns were then compared to a human phase response curve (PRC) to light. Results Relative to clock time, individuals with DSWPD had a later light exposure pattern compared to controls, but their light exposure pattern was earlier relative to DLMO. According to the human phase response curve (PRC) to light, individuals with DSWPD had less daily advancing light exposure compared to controls. The primary difference was seen in the late portion of the advancing window, in which individuals with DSWPD were exposed to fewer pulses of light of equivalent duration and intensity compared to controls. Conclusions Diminished advancing light exposure may play a role in the development and perpetuation of delayed sleep-wake timing in individuals with DSWPD. Enhancing light exposure during the later portion of the advancing window represents an innovative and complementary strategy that has the potential to improve the effectiveness of bright light therapy in DSWPD. |
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0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | GFZ @ kyba @ | Serial | 1990 | ||
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| Author | Mindel, J.W.; Rojas, S.L.; Kline, D.; Bao, S.; Rezai, A.; Corrigan, J.D.; Nelson, R.J.; D, P.; Magalang, U.J. | ||||
| Title | 0038 Sleeping with Low Levels of Artificial Light at Night Increases Systemic Inflammation in Humans | Type | Journal Article | ||
| Year | 2019 | Publication | Sleep | Abbreviated Journal | |
| Volume | 42 | Issue | Supplement_1 | Pages | A15-A16 |
| Keywords | Human Health | ||||
| Abstract | Introduction Artificial light at night (ALAN) has become a ubiquitous part of our society. Animal studies have shown that ALAN exposure promotes a depressive-like mood and increases peripheral inflammation likely due to circadian disruption. We hypothesized that sleeping with ALAN will increase systemic inflammation in humans. Methods We enrolled 64 subjects [32 with obstructive sleep apnea (OSA) adherent to treatment and 32 without sleep disorders] in a randomized, crossover study to determine the effects of sleeping with ALAN (40 lux) or the usual dark condition (control) for 7 nights at home. Sleeping with ALAN was confirmed by an actigraph with an ambient light sensor. Outcome measurements were done at baseline and after sleeping in each condition. The primary outcome was changes in the high-sensitivity C-reactive protein (hsCRP) levels. Secondary outcomes include scores on the Pittsburgh Sleep Quality Index (PSQI), Center for Epidemiologic Studies Depression Scale (CES-D), Functional Outcomes of Sleep Questionnaire-10 (FOSQ-10), and Epworth Sleepiness Scale (ESS); Psychomotor Vigilance Testing (PVT); actigraphic sleep measures; and homeostatic model assessment of insulin resistance (HOMA-IR). A random effects linear regression model was used to assess differences adjusting for schedule, visit, and baseline levels. Post-hoc analyses combined results from OSA and non-OSA subjects. Results Fifty-eight (30 OSA and 28 non-OSA) subjects, aged 38.4±14.9 years, 33 of whom are male completed the protocol. A log transformation was used so the difference in hsCRP was expressed as a mean ratio. In the combined analysis, the mean hsCRP was 39% higher with ALAN than control (mean ratio=1.39; 95% CI: 1.08-1.80; p=0.012). The effects of ALAN for OSA and non-OSA subjects were not different. ALAN increased the CES-D score by 1.81 (p=0.017) and ESS score by 0.62 (p=0.071) points, and decreased the FOSQ-10 score by 0.36 (p=0.038) points while the PSQI score was unchanged (p=0.860). There were no significant differences in the PVT values, actigraphic sleep measures, or HOMA-IR. Conclusion Sleeping with ALAN for seven days significantly increased hsCRP levels and modestly increased depression scores in humans. |
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| ISSN |
0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | GFZ @ kyba @ | Serial | 2322 | ||
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| Author | Dhaliwal, S.S.; Keller, J.; Le, H.-N.; Lewin, D.S. | ||||
| Title | Sleep Disturbance among Pregnant Women: The Influence of Environmental and Contextual Factors | Type | Journal Article | ||
| Year | 2019 | Publication | Sleep | Abbreviated Journal | |
| Volume | 42 | Issue | Supplement_1 | Pages | A270-A271 |
| Keywords | Human Health | ||||
| Abstract | Introduction Disrupted sleep during pregnancy affects nearly 85% of women. This can contribute to psychological distress and antenatal depression. The aims of the current project were to test whether (a) poorer subjective sleep quality contributed to greater depression and anxiety symptoms, and (b) contextual factors predicted clinically significant sleep disturbance after adjusting for socioeconomic status (SES). Methods In a mixed-methods study, 418 pregnant women (age: M=32.4 years; gestation: M=28.4 weeks, SD=8.4 weeks; 58% Black) completed the Pittsburgh Sleep Quality Index (PSQI), measures of pregnancy-related physiological factors, and provided details about their sleep environment. They also rated perinatal depression, anxiety, and SES (Hollingshead and MacArthur Ladder). Sixty-two women completed these measures again later in pregnancy (gestation M = 34.2 weeks). A subset of seven women underwent actigraphy (9-nights) during their third trimester. Logistic regressions adjusted for age, BMI, race, sleep disordered breathing, and gestational week. Results Subjective sleep quality was significantly poorer among Black women and those with higher BMI. Physiological factors (i.e., restless leg syndrome, nocturnal urination, and acid reflux) explained subjective sleep disturbance after accounting for gestational week (ps<.01). Among women with history of psychopathology (n=221), sleep disturbance was significantly related to anxiety and depression symptoms (ps<.01), with greater sleep disturbance (PSQI score >5) predicting clinically significant antenatal depression (B = .38, p<.05). However, those who rated their social standing as higher reported lower sleep disturbance throughout pregnancy, even after adjusting for mood and anxiety (B= .86, SE =.41; p<.05). There was a dose-response positive association between sleep disturbance and depression severity among Black women only (B = .89; p<.05). Among lower SES Black women, environmental factors (greater ambient noise and light pollution) partially mediated this effect (B= .45, SE =.17; p<.01). Conclusion Sociocontextual factors may explain sleep disturbance severity among low-income pregnant Black women, above and beyond traditional metrics of SES. Higher subjective SES may be protective against sleep disturbance and psychiatric distress. Assessments of sleep during pregnancy should account for physiological considerations and environmental disruptions, alongside mood and anxiety. |
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| ISSN |
0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | GFZ @ kyba @ | Serial | 2323 | ||
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| Author | Ohayon, M.M.; Milesi, C. | ||||
| Title | Artificial Outdoor Nighttime Lights Associate with Altered Sleep Behavior in the American General Population | Type | Journal Article | ||
| Year | 2016 | Publication | Sleep | Abbreviated Journal | Sleep |
| Volume | 39 | Issue | 6 | Pages | 1311-1320 |
| Keywords | Human Health; Remote Sensing; Sleep | ||||
| Abstract | STUDY OBJECTIVES: Our study aims to explore the associations between outdoor nighttime lights (ONL) and sleep patterns in the human population. METHODS: Cross-sectional telephone study of a representative sample of the general US population age 18 y or older. 19,136 noninstitutionalized individuals (participation rate: 83.2%) were interviewed by telephone. The Sleep-EVAL expert system administered questions on life and sleeping habits; health; sleep, mental and organic disorders (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision; International Classification of Sleep Disorders, Second Edition; International Classification of Diseases, 10(th) Edition). Individuals were geolocated by longitude and latitude. Outdoor nighttime light measurements were obtained from the Defense Meteorological Satellite Program's Operational Linescan System (DMSP/OLS), with nighttime passes taking place between 19:30 and 22:30 local time. Light data were correlated precisely to the geolocation of each participant of the general population sample. RESULTS: Living in areas with greater ONL was associated with delayed bedtime (P < 0.0001) and wake up time (P < 0.0001), shorter sleep duration (P < 0.01), and increased daytime sleepiness (P < 0.0001). Living in areas with greater ONL also increased the dissatisfaction with sleep quantity and quality (P < 0.0001) and the likelihood of having a diagnostic profile congruent with a circadian rhythm disorder (P < 0.0001). CONCLUSIONS: Although they improve the overall safety of people and traffic, nighttime lights in our streets and cities are clearly linked with modifications in human sleep behaviors and also impinge on the daytime functioning of individuals living in areas with greater ONL. | ||||
| Address | NASA Ames Research Center, Moffett Field, CA | ||||
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| Language | English | Summary Language | Original Title | ||
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| Series Volume | Series Issue | Edition | |||
| ISSN |
0161-8105 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:27091523; PMCID:PMC4863221 | Approved | no | ||
| Call Number | GFZ @ kyba @ | Serial | 2551 | ||
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