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Author Mindel, J.W.; Rojas, S.L.; Kline, D.; Bao, S.; Rezai, A.; Corrigan, J.D.; Nelson, R.J.; D, P.; Magalang, U.J. url  doi
openurl 
  Title 0038 Sleeping with Low Levels of Artificial Light at Night Increases Systemic Inflammation in Humans Type Journal Article
  Year 2019 Publication Sleep Abbreviated Journal  
  Volume 42 Issue Supplement_1 Pages A15-A16  
  Keywords Human Health  
  Abstract Introduction

Artificial light at night (ALAN) has become a ubiquitous part of our society. Animal studies have shown that ALAN exposure promotes a depressive-like mood and increases peripheral inflammation likely due to circadian disruption. We hypothesized that sleeping with ALAN will increase systemic inflammation in humans.

Methods

We enrolled 64 subjects [32 with obstructive sleep apnea (OSA) adherent to treatment and 32 without sleep disorders] in a randomized, crossover study to determine the effects of sleeping with ALAN (40 lux) or the usual dark condition (control) for 7 nights at home. Sleeping with ALAN was confirmed by an actigraph with an ambient light sensor. Outcome measurements were done at baseline and after sleeping in each condition. The primary outcome was changes in the high-sensitivity C-reactive protein (hsCRP) levels. Secondary outcomes include scores on the Pittsburgh Sleep Quality Index (PSQI), Center for Epidemiologic Studies Depression Scale (CES-D), Functional Outcomes of Sleep Questionnaire-10 (FOSQ-10), and Epworth Sleepiness Scale (ESS); Psychomotor Vigilance Testing (PVT); actigraphic sleep measures; and homeostatic model assessment of insulin resistance (HOMA-IR). A random effects linear regression model was used to assess differences adjusting for schedule, visit, and baseline levels. Post-hoc analyses combined results from OSA and non-OSA subjects.

Results

Fifty-eight (30 OSA and 28 non-OSA) subjects, aged 38.4±14.9 years, 33 of whom are male completed the protocol. A log transformation was used so the difference in hsCRP was expressed as a mean ratio. In the combined analysis, the mean hsCRP was 39% higher with ALAN than control (mean ratio=1.39; 95% CI: 1.08-1.80; p=0.012). The effects of ALAN for OSA and non-OSA subjects were not different. ALAN increased the CES-D score by 1.81 (p=0.017) and ESS score by 0.62 (p=0.071) points, and decreased the FOSQ-10 score by 0.36 (p=0.038) points while the PSQI score was unchanged (p=0.860). There were no significant differences in the PVT values, actigraphic sleep measures, or HOMA-IR.

Conclusion

Sleeping with ALAN for seven days significantly increased hsCRP levels and modestly increased depression scores in humans.
 
  Address  
  Corporate Author Thesis  
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  Language (up) Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2322  
Permanent link to this record
 

 
Author Dhaliwal, S.S.; Keller, J.; Le, H.-N.; Lewin, D.S. url  doi
openurl 
  Title Sleep Disturbance among Pregnant Women: The Influence of Environmental and Contextual Factors Type Journal Article
  Year 2019 Publication Sleep Abbreviated Journal  
  Volume 42 Issue Supplement_1 Pages A270-A271  
  Keywords Human Health  
  Abstract Introduction

Disrupted sleep during pregnancy affects nearly 85% of women. This can contribute to psychological distress and antenatal depression. The aims of the current project were to test whether (a) poorer subjective sleep quality contributed to greater depression and anxiety symptoms, and (b) contextual factors predicted clinically significant sleep disturbance after adjusting for socioeconomic status (SES).

Methods

In a mixed-methods study, 418 pregnant women (age: M=32.4 years; gestation: M=28.4 weeks, SD=8.4 weeks; 58% Black) completed the Pittsburgh Sleep Quality Index (PSQI), measures of pregnancy-related physiological factors, and provided details about their sleep environment. They also rated perinatal depression, anxiety, and SES (Hollingshead and MacArthur Ladder). Sixty-two women completed these measures again later in pregnancy (gestation M = 34.2 weeks). A subset of seven women underwent actigraphy (9-nights) during their third trimester. Logistic regressions adjusted for age, BMI, race, sleep disordered breathing, and gestational week.

Results

Subjective sleep quality was significantly poorer among Black women and those with higher BMI. Physiological factors (i.e., restless leg syndrome, nocturnal urination, and acid reflux) explained subjective sleep disturbance after accounting for gestational week (ps<.01). Among women with history of psychopathology (n=221), sleep disturbance was significantly related to anxiety and depression symptoms (ps<.01), with greater sleep disturbance (PSQI score >5) predicting clinically significant antenatal depression (B = .38, p<.05). However, those who rated their social standing as higher reported lower sleep disturbance throughout pregnancy, even after adjusting for mood and anxiety (B= .86, SE =.41; p<.05). There was a dose-response positive association between sleep disturbance and depression severity among Black women only (B = .89; p<.05). Among lower SES Black women, environmental factors (greater ambient noise and light pollution) partially mediated this effect (B= .45, SE =.17; p<.01).

Conclusion

Sociocontextual factors may explain sleep disturbance severity among low-income pregnant Black women, above and beyond traditional metrics of SES. Higher subjective SES may be protective against sleep disturbance and psychiatric distress. Assessments of sleep during pregnancy should account for physiological considerations and environmental disruptions, alongside mood and anxiety.
 
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  Language (up) Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2323  
Permanent link to this record
 

 
Author Woods, H. C., & Scott, H. url  doi
openurl 
  Title Merging the Biological and Cognitive Processes of Sleep and Screens Type Journal Article
  Year 2019 Publication Current Sleep Medicine Reports Abbreviated Journal  
  Volume 5 Issue 3 Pages 150-155  
  Keywords Human Health  
  Abstract Purpose of Review

Screens are a permanent feature of life today and we have reached an interesting juncture with different research agendas investigating the biological and cognitive aspects of screen use separately. This review argues that it is timely and indeed essential that we bring together these research areas to fully understand both positive and negative aspects of screen use.

Recent Findings

More recent work is starting to take a more cohesive approach to understanding how device use pre-bedtime can impact our sleep by including both light and content in their experimental protocols which is a welcome development leading to a more nuanced understanding of both biological and cognitive processes.

Summary

We call for an open and collaborative approach to gain momentum in this direction of acknowledging both biological and cognitive factors enabling us to understand the relative impacts of both whilst using screens with regard to both light and content.
 
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  Notes Approved no  
  Call Number IDA @ intern @ Serial 2640  
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Author Walbeek, T.J.; Harrison, E.M.; Soler, R.R.; Gorman, M.R. url  doi
openurl 
  Title Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules Type Journal Article
  Year 2019 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 1 Issue 3 Pages 394-413  
  Keywords Animals  
  Abstract The circadian system is generally considered to be incapable of adjusting to rapid changes in sleep/work demands. In shiftworkers this leads to chronic circadian disruption and sleep loss, which together predict underperformance at work and negative health consequences. Two distinct experimental protocols have been proposed to increase circadian flexibility in rodents using dim light at night: rhythm bifurcation and T-cycle (i.e., day length) entrainment. Successful translation of such protocols to human shiftworkers could facilitate alignment of internal time with external demands. To assess entrainment flexibility following bifurcation and exposure to T-cycles, mice in Study 1 were repeatedly phase-shifted. Mice from experimental conditions rapidly phase-shifted their activity, while control mice showed expected transient misalignment. In Study 2 and 3, mice followed a several weeks-long intervention designed to model a modified DuPont or Continental shiftwork schedule, respectively. For both schedules, bifurcation and nocturnal dim lighting reduced circadian misalignment. Together, these studies demonstrate proof of concept that mammalian circadian systems can be rendered sufficiently flexible to adapt to multiple, rapidly changing shiftwork schedules. Flexible adaptation to exotic light-dark cycles likely relies on entrainment mechanisms that are distinct from traditional entrainment.  
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  Language (up) Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2661  
Permanent link to this record
 

 
Author Cho, J.R.; Joo, E.Y.; Koo, D.L.; Hong, S.B. url  doi
openurl 
  Title Let there be no light: the effect of bedside light on sleep quality and background electroencephalographic rhythms Type Journal Article
  Year 2013 Publication Sleep Medicine Abbreviated Journal Sleep Med  
  Volume 14 Issue 12 Pages 1422-1425  
  Keywords Eeg; Light; Polysomnography; Sleep; Sleep spindle; Slow oscillation  
  Abstract OBJECTIVES: Artificial lighting has been beneficial to society, but unnecessary light exposure at night may cause various health problems. We aimed to investigate how whole-night bedside light can affect sleep quality and brain activity. PATIENTS AND METHODS: Ten healthy sleepers underwent two polysomnography (PSG) sessions, one with the lights off and one with the lights on. PSG variables related to sleep quality were extracted and compared between lights-off and lights-on sleep. Spectral analysis was performed to rapid eye movement (REM) sleep and non-REM (NREM) sleep epochs to reveal any light-induced differences in background brain rhythms. RESULTS: Lights-on sleep was associated with increased stage 1 sleep (N1), decreased slow-wave sleep (SWS), and increased arousal index. Spectral analysis revealed that theta power (4-8Hz) during REM sleep and slow oscillation (0.5-1Hz), delta (1-4Hz), and spindle (10-16Hz) power during NREM sleep were decreased in lights-on sleep conditions. CONCLUSIONS: Sleeping with the light on not only causes shallow sleep and frequent arousals but also has a persistent effect on brain oscillations, especially those implicated in sleep depth and stability. Our study demonstrates additional hazardous effect of light pollution on health.  
  Address Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Samsung Biomedical Research Institute, Seoul, Republic of Korea; Division of Computation and Neural Systems, California Institute of Technology, Pasadena, California, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language (up) English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1389-9457 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24210607 Approved no  
  Call Number IDA @ john @ Serial 141  
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