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Author Kessel, L.; Siganos, G.; Jorgensen, T.; Larsen, M. url  doi
openurl 
  Title Sleep disturbances are related to decreased transmission of blue light to the retina caused by lens yellowing Type Journal Article
  Year 2011 Publication Sleep Abbreviated Journal Sleep  
  Volume 34 Issue 9 Pages 1215-1219  
  Keywords Adult; Age Factors; Aging/*pathology/physiology; Circadian Rhythm/physiology; Cross-Sectional Studies; Female; Fluorometry; Humans; Lens, Crystalline/*pathology/physiopathology; *Light; Male; Middle Aged; Retina/*physiopathology; Risk Factors; *Scattering, Radiation; Sleep Disorders/*etiology; Circadian rhythm; cataract; melanopsin; sleep; blue light  
  Abstract STUDY OBJECTIVES: Sleep pattern and circadian rhythms are regulated via the retinohypothalamic tract in response to stimulation of a subset of retinal ganglion cells, predominantly by blue light (450-490 nm). With age, the transmission of blue light to the retina is reduced because of the aging process of the human lens, and this may impair the photoentrainment of circadian rhythm leading to sleep disorders. The aim of the study was to examine the association between lens aging and sleep disorders. DESIGN: Cross-sectional population based study. SETTING: The study was performed at the Research Center for Prevention and Health, Glostrup Hospital, Denmark and at the Department of Ophthalmology, Herlev Hospital, Denmark. PARTICIPANTS: An age- and sex-stratified sample of 970 persons aged 30 to 60 years of age drawn from a sample randomly selected from the background population. INTERVENTIONS: Not applicable. MEASUREMENTS AND RESULTS: Sleep disturbances were evaluated by a combination of questionnaire and the use of prescription sleeping medication. Lens aging (transmission and yellowing) was measured objectively by lens autofluorometry. The risk of sleep disturbances was significantly increased when the transmission of blue light to the retina was low, even after correction for the effect of age and other confounding factors such as smoking habits, diabetes mellitus, gender, and the risk of ischemic heart disease (P < 0.0001). CONCLUSIONS: Filtration of blue light by the aging lens was significantly associated with an increased risk of sleep disturbances. We propose that this is a result of disturbance of photoentrainment of circadian rhythms.  
  Address Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark. line.kessel@dadlnet.dk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:21886359; PMCID:PMC3157663 Approved no  
  Call Number IDA @ john @ Serial 344  
Permanent link to this record
 

 
Author Haus, E.L.; Smolensky, M.H. url  doi
openurl 
  Title Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation Type Journal Article
  Year 2013 Publication Sleep Medicine Reviews Abbreviated Journal Sleep Med Rev  
  Volume 17 Issue 4 Pages 273-284  
  Keywords Cell Cycle/physiology; Circadian Rhythm/*physiology; Epigenesis, Genetic/physiology; Humans; Light; Melatonin/physiology; Neoplasms/*etiology; Risk Factors; Sleep Deprivation/*complications; Work Schedule Tolerance/*physiology; oncogenesis  
  Abstract Shift work that includes a nighttime rotation has become an unavoidable attribute of today's 24-h society. The related disruption of the human circadian time organization leads in the short-term to an array of jet-lag-like symptoms, and in the long-run it may contribute to weight gain/obesity, metabolic syndrome/type II diabetes, and cardiovascular disease. Epidemiologic studies also suggest increased cancer risk, especially for breast cancer, in night and rotating female shift workers. If confirmed in more controlled and detailed studies, the carcinogenic effect of night and shift work will constitute additional serious medical, economic, and social problems for a substantial proportion of the working population. Here, we examine the possible multiple and interconnected cancer-promoting mechanisms as a consequence of shift work, i.e., repeated disruption of the circadian system, pineal hormone melatonin suppression by exposure to light at night, sleep-deprivation-caused impairment of the immune system, plus metabolic changes favoring obesity and generation of proinflammatory reactive oxygen species.  
  Address Department of Laboratory Medicine & Pathology, University of Minnesota and Health Partners Medical Group, Regions Hospital, 640 Jackson Street, St. Paul, Minnesota 55101, USA. Erhard.X.Haus@HealthPartners.com  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1087-0792 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:23137527 Approved no  
  Call Number IDA @ john @ Serial 157  
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Author Escobar, C.; Salgado-Delgado, R.; Gonzalez-Guerra, E.; Tapia Osorio, A.; Angeles-Castellanos, M.; Buijs, R.M. url  doi
openurl 
  Title Circadian disruption leads to loss of homeostasis and disease Type Journal Article
  Year 2011 Publication Sleep Disorders Abbreviated Journal Sleep Disord  
  Volume 2011 Issue Pages 964510  
  Keywords Human Health  
  Abstract The relevance of a synchronized temporal order for adaptation and homeostasis is discussed in this review. We present evidence suggesting that an altered temporal order between the biological clock and external temporal signals leads to disease. Evidence mainly based on a rodent model of “night work” using forced activity during the sleep phase suggests that altered activity and feeding schedules, out of phase from the light/dark cycle, may be the main cause for the loss of circadian synchrony and disease. It is proposed that by avoiding food intake during sleep hours the circadian misalignment and adverse consequences can be prevented. This review does not attempt to present a thorough revision of the literature, but instead it aims to highlight the association between circadian disruption and disease with special emphasis on the contribution of feeding schedules in circadian synchrony.  
  Address Departamento de Anatomia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, 04360 Mexico City, DF, Mexico  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2090-3553 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:23471148; PMCID:PMC3581131 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 745  
Permanent link to this record
 

 
Author Chellappa, S.L.; Steiner, R.; Oelhafen, P.; Lang, D.; Gotz, T.; Krebs, J.; Cajochen, C. url  doi
openurl 
  Title Acute exposure to evening blue-enriched light impacts on human sleep Type Journal Article
  Year 2013 Publication Journal of Sleep Research Abbreviated Journal J Sleep Res  
  Volume 22 Issue 5 Pages 573-580  
  Keywords Human Health  
  Abstract Light in the short wavelength range (blue light: 446-483 nm) elicits direct effects on human melatonin secretion, alertness and cognitive performance via non-image-forming photoreceptors. However, the impact of blue-enriched polychromatic light on human sleep architecture and sleep electroencephalographic activity remains fairly unknown. In this study we investigated sleep structure and sleep electroencephalographic characteristics of 30 healthy young participants (16 men, 14 women; age range 20-31 years) following 2 h of evening light exposure to polychromatic light at 6500 K, 2500 K and 3000 K. Sleep structure across the first three non-rapid eye movement non-rapid eye movement – rapid eye movement sleep cycles did not differ significantly with respect to the light conditions. All-night non-rapid eye movement sleep electroencephalographic power density indicated that exposure to light at 6500 K resulted in a tendency for less frontal non-rapid eye movement electroencephalographic power density, compared to light at 2500 K and 3000 K. The dynamics of non-rapid eye movement electroencephalographic slow wave activity (2.0-4.0 Hz), a functional index of homeostatic sleep pressure, were such that slow wave activity was reduced significantly during the first sleep cycle after light at 6500 K compared to light at 2500 K and 3000 K, particularly in the frontal derivation. Our data suggest that exposure to blue-enriched polychromatic light at relatively low room light levels impacts upon homeostatic sleep regulation, as indexed by reduction in frontal slow wave activity during the first non-rapid eye movement episode.  
  Address Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland; Cyclotron Research Center, University of Liege, Liege, Belgium  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0962-1105 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:23509952 Approved no  
  Call Number GFZ @ kyba @ Serial 2201  
Permanent link to this record
 

 
Author Shochat, T. url  doi
openurl 
  Title Impact of lifestyle and technology developments on sleep Type Journal Article
  Year 2012 Publication Nature and Science of Sleep Abbreviated Journal Nat Sci Sleep  
  Volume 4 Issue Pages 19-31  
  Keywords Human Health; behavior; lifestyle; sleep; technology  
  Abstract Although the physiological and psychological mechanisms involved in the development of sleep disorders remain similar throughout history, factors that potentiate these mechanisms are closely related to the “zeitgeist”, ie, the sociocultural, technological and lifestyle trends which characterize an era. Technological advancements have afforded modern society with 24-hour work operations, transmeridian travel and exposure to a myriad of electronic devices such as televisions, computers and cellular phones. Growing evidence suggests that these advancements take their toll on human functioning and health via their damaging effects on sleep quality, quantity and timing. Additional behavioral lifestyle factors associated with poor sleep include weight gain, insufficient physical exercise and consumption of substances such as caffeine, alcohol and nicotine. Some of these factors have been implicated as self-help aids used to combat daytime sleepiness and impaired daytime functioning. This review aims to highlight current lifestyle trends that have been shown in scientific investigations to be associated with sleep patterns, sleep duration and sleep quality. Current understanding of the underlying mechanisms of these associations will be presented, as well as some of the reported consequences. Available therapies used to treat some lifestyle related sleep disorders will be discussed. Perspectives will be provided for further investigation of lifestyle factors that are associated with poor sleep, including developing theoretical frameworks, identifying underlying mechanisms, and establishing appropriate therapies and public health interventions aimed to improve sleep behaviors in order to enhance functioning and health in modern society.  
  Address Department of Nursing, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1179-1608 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:23616726; PMCID:PMC3630968 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 515  
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