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Crowley, S.J.; Suh, C.; Molina, T.A.; Fogg, L.F.; Sharkey, K.M.; Carskadon, M.A. |
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Estimating the dim light melatonin onset of adolescents within a 6-h sampling window: the impact of sampling rate and threshold method |
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Journal Article |
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2015 |
Publication |
Sleep Medicine |
Abbreviated Journal |
Sleep Medicine |
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20 |
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59-66 |
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Human Health |
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1389-9457 |
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LoNNe @ kyba @ |
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1324 |
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Author |
WDS Killgore |
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Title |
Lighting the Way to Better Sleep and Health |
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Journal Article |
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Year |
2016 |
Publication |
Journal of Sleep Disorders: Treatment and Care |
Abbreviated Journal |
J Sleep Disor: Treat Care |
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05 |
Issue |
01 |
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Keywords |
Health; Editorial |
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2325-9639 |
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LoNNe @ kyba @ |
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1442 |
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Author |
Pereira, É.F.; Louzada, F.M.; Moreno, C.R.C. |
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Title |
Not all adolescents are sleep deprived: A study of rural populations: Sleep duration in rural populations |
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Journal Article |
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Year |
2010 |
Publication |
Sleep and Biological Rhythms |
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8 |
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4 |
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267-273 |
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Human Health; Sleep |
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Abstract |
The objective of this study was to investigate the role of environmental factors in sleep duration among adolescents living in rural areas. A total of 1140 students (569 males), aged 10–19 years, and attending two schools in rural regions in southern Brazil, completed a questionnaire about their sleep habits. Demographic data were also obtained. Prevalence ratios (PR) were estimated for the cases of more than 9 h of sleep on weekdays. Sleep duration in adolescents with and without electric lighting at home was analyzed. Average sleep duration at night was 9.63 (1.64) h on school-going days and 10.14 (2.42) h on weekends. The prevalence of adolescents sleeping for more than 9 h at night on school-going days was 58.3%. Older adolescents showed a tendency to delay their sleep onset times, which is associated with a reduction of sleep duration. Adolescents without electric lighting at home slept longer on school-going days (P < 0.001) and on weekends (P= 0.013) when compared to those with electric lighting at home. From multivariate analysis, age (P < 0.001), school schedule (P= 0.007) and work (0.042) were factors affecting sleep duration. In contrast to the data previously reported for urban populations, we found a high prevalence of adolescents sleeping for more than 9 h on school nights. Data on populations living in less industrialized regions reinforce the idea that technological advances are associated with the negative impact of sleep phase delay in adolescents. |
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1446-9235 |
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LoNNe @ kyba @ |
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1482 |
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Wang, H.-B.; Whittaker, D.S.; Truong, D.; Mulji, A.K.; Ghiani, C.A.; Loh, D.H.; Colwell, C.S. |
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Title |
Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease |
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Journal Article |
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Year |
2017 |
Publication |
Neurobiology of Sleep and Circadian Rhythms |
Abbreviated Journal |
Neurobiology of Sleep and Circadian Rhythms |
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2 |
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39-52 |
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Keywords |
animals; Human Health |
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Abstract |
Patients with Huntington's disease (HD) exhibit movement disorders, psychiatric disturbance and cognitive impairments as the disease progresses. Abnormal sleep/wake cycles are common among HD patients with reports of delayed sleep onset, fatigue during the day, and a delayed pattern of melatonin secretion all of which suggest circadian dysfunction. Mouse models of HD confirm disrupted circadian rhythms with pathophysiology found in the central circadian clock (suprachiasmatic nucleus). Importantly, circadian dysfunction manifests early in disease, even before the classic motor symptoms, in both patients and mouse models. Therefore, we hypothesize that the circadian dysfunction may interact with the disease pathology and exacerbate the HD symptoms. If correct, early intervention may benefit patients and delay disease progression. One test of this hypothesis is to determine whether light therapy designed to strengthen this intrinsic timing system can delay the disease progression in mouse models. Therefore, we determined the impact of blue wavelength-enriched light on two HD models: the BACHD and Q175 mice. Both models received 6 hours of blue-light at the beginning of their daily light cycle for 3 months. After treatment, both genotypes showed improvements in their locomotor activity rhythm without significant change to their sleep behavior. Critically, treated mice of both lines exhibited improved motor performance compared to untreated controls. Focusing on the Q175 genotype, we sought to determine whether the treatment altered signaling pathways in brain regions known to be impacted by HD using NanoString gene expression assays. We found that the expression of several HD relevant markers was altered in the striatum and cortex of the treated mice. Our study demonstrates that strengthening the circadian system can delay the progression of HD in pre-clinical models. This work suggests that lighting conditions should be considered when managing treatment of HD and other neurodegenerative disorders. |
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2451-9944 |
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LoNNe @ kyba @ |
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1626 |
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Wilson IV, J.; Reid, K.J.; Braun, R.I.; Abbott, S.M.; Zee, P.C. |
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Title |
Habitual Light Exposure Relative to Circadian Timing in Delayed Sleep-Wake Phase Disorder |
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Journal Article |
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2018 |
Publication |
Sleep |
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in press |
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Human Health |
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Abstract |
Study Objectives
To compare melatonin timing, a well validated marker for endogenous circadian phase, and habitual light exposure patterns in adults with delayed sleep-wake phase disorder (DSWPD) and intermediate chronotype controls.
Methods
12 individuals with DSWPD (5 females, mean age 31.1) and 12 age matched controls (6 females, mean age 33.6) underwent a minimum of seven days of light and activity monitoring followed by an inpatient hospital stay, where blood was taken to assess melatonin timing (calculated as dim light melatonin onset – DLMO). Habitual light exposure patterns were then compared to a human phase response curve (PRC) to light.
Results
Relative to clock time, individuals with DSWPD had a later light exposure pattern compared to controls, but their light exposure pattern was earlier relative to DLMO. According to the human phase response curve (PRC) to light, individuals with DSWPD had less daily advancing light exposure compared to controls. The primary difference was seen in the late portion of the advancing window, in which individuals with DSWPD were exposed to fewer pulses of light of equivalent duration and intensity compared to controls.
Conclusions
Diminished advancing light exposure may play a role in the development and perpetuation of delayed sleep-wake timing in individuals with DSWPD. Enhancing light exposure during the later portion of the advancing window represents an innovative and complementary strategy that has the potential to improve the effectiveness of bright light therapy in DSWPD. |
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0161-8105 |
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GFZ @ kyba @ |
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1990 |
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