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Author Skene, D.J.; Arendt, J.
Title Circadian rhythm sleep disorders in the blind and their treatment with melatonin Type Journal Article
Year 2007 Publication Sleep Medicine Abbreviated Journal Sleep Med
Volume 8 Issue 6 Pages 651-655
Keywords Human Health; Blindness/*complications; Chronotherapy; Circadian Rhythm/drug effects; Humans; Melatonin/*administration & dosage; Sleep/drug effects; Sleep Disorders, Circadian Rhythm/*drug therapy/*etiology; Treatment Outcome
Abstract People who are blind, in addition to having to cope with partial or no sight, have an added handicap; the transmission of ocular light from the retina to their circadian clock is impaired. At its worse, for example in people with both eyes enucleated, this lesion results in desynchronisation of the biological clock (located in the hypothalamic suprachiasmatic nuclei) from the 24h day/night environment. While in a desynchronised state, symptoms akin to jet lag are experienced (e.g., daytime sleepiness, poor night sleep, reduced alertness and performance during waking). This is a lifelong condition. Daily administration of exogenous melatonin is the current treatment of choice for this so-called “non-24h sleep/wake disorder”. Melatonin has been shown to correct the underlying circadian rhythm abnormality as well as improve sleep and reduce daytime napping. The effectiveness of melatonin therapy depends upon its time of administration relative to the timing of the person's circadian clock. If practicable, assessment of an individual's circadian phase (by measurement of the endogenous melatonin rhythm in plasma, saliva or urine) is recommended prior to commencing treatment to optimise melatonin's effectiveness.
Address Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK. d.skene@surrey.ac.uk
Corporate Author Thesis
Publisher (up) Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1389-9457 ISBN Medium
Area Expedition Conference
Notes PMID:17420154 Approved no
Call Number LoNNe @ kagoburian @ Serial 811
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Author Paul, M.A.; Love, R.J.; Hawton, A.; Brett, K.; McCreary, D.R.; Arendt, J.
Title Sleep deficits in the high Arctic summer in relation to light exposure and behaviour: use of melatonin as a countermeasure Type Journal Article
Year 2015 Publication Sleep Medicine Abbreviated Journal Sleep Medicine
Volume Issue Pages
Keywords Human Health; Sleep
Abstract
Address
Corporate Author Thesis
Publisher (up) Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1389-9457 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ christopher.kyba @ Serial 1093
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Author Crowley, S.J.; Suh, C.; Molina, T.A.; Fogg, L.F.; Sharkey, K.M.; Carskadon, M.A.
Title Estimating the dim light melatonin onset of adolescents within a 6-h sampling window: the impact of sampling rate and threshold method Type Journal Article
Year 2015 Publication Sleep Medicine Abbreviated Journal Sleep Medicine
Volume 20 Issue Pages 59-66
Keywords Human Health
Abstract
Address
Corporate Author Thesis
Publisher (up) Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1389-9457 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1324
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Author WDS Killgore
Title Lighting the Way to Better Sleep and Health Type Journal Article
Year 2016 Publication Journal of Sleep Disorders: Treatment and Care Abbreviated Journal J Sleep Disor: Treat Care
Volume 05 Issue 01 Pages
Keywords Health; Editorial
Abstract
Address
Corporate Author Thesis
Publisher (up) Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2325-9639 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kyba @ Serial 1442
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Author Peixoto, C.A.T.; da Silva, A.G.T.; Carskadon, M.A.; Louzada, F.M.
Title Adolescents living in homes without electric lighting have earlier sleep times Type Journal Article
Year 2009 Publication Behavioral Sleep Medicine Abbreviated Journal Behav Sleep Med
Volume 7 Issue 2 Pages 73-80
Keywords Human Health; Sleep
Abstract The aim of this project was to compare circadian rhythmicity of a group of 37 adolescents (14 girls), aged 11 to 16 (mean age = 13.1 +/- 1.7 years), with and without electricity at home. Twenty students attended morning school (07:30-11:30), and 17 attended evening school classes (19:00-22:30). Eleven adolescents had no electric lighting at home (5 attended morning classes and 6 attended evening classes). They completed a sleep log and wore a wrist actigraph for 5 consecutive days. Saliva samples were collected to assess DLMO. Data were compared by ANOVA and showed later timing and a more extended sleep period for those who attended late classes. Those adolescents without electricity at home had significantly earlier sleep onset on school days. As to DLMO, a trend to a delay was observed in the groups who had electric lighting.
Address Department of Physiology, Universidade Federal do Parana, Brazil. pedatardelli@yahoo.com.br
Corporate Author Thesis
Publisher (up) Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1540-2002 ISBN Medium
Area Expedition Conference
Notes PMID:19330580 Approved no
Call Number LoNNe @ kyba @ Serial 1481
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