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Author Sletten, T.L.; Cappuccio, F.P.; Davidson, A.J.; Van Cauter, E.; Rajaratnam, S.M.W.; Scheer, F.A.J.L. url  doi
openurl 
  Title Health consequences of circadian disruption Type Journal Article
  Year 2020 Publication Sleep Abbreviated Journal Sleep  
  Volume 43 Issue 1 Pages  
  Keywords Human Health; Circadian Rhythm; Chronobiology; Sleep; Review  
  Abstract The circadian system is key for optimal functioning by maintaining synchrony between internal circadian rhythms, behaviors, and external cues. Many clinicians are not fully aware, however, of the far-reaching implications of the circadian system for human health. Clinical attention to circadian rhythms has largely focused on sleep disturbances. The impact of the circadian system on health is, however, much broader. Clinical diagnoses are often based on single time point assessments during the day, ignoring circadian influences on physiology. Even when time is considered, using (external) clock time ignores the large interindividual differences in internal timing.  
  Address Division of Sleep Medicine, Harvard Medical School, Boston, MA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language (up) Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31930347 Approved no  
  Call Number IDA @ john @ Serial 2822  
Permanent link to this record
 

 
Author Dautovich, N.D.; Schreiber, D.R.; Imel, J.L.; Tighe, C.A.; Shoji, K.D.; Cyrus, J.; Bryant, N.; Lisech, A.; O'Brien, C.; Dzierzewski, J.M. url  doi
openurl 
  Title A systematic review of the amount and timing of light in association with objective and subjective sleep outcomes in community-dwelling adults Type Journal Article
  Year 2019 Publication Sleep Health Abbreviated Journal Sleep Health  
  Volume 5 Issue 1 Pages 31–48  
  Keywords Human Health; Review; light timing; Sleep  
  Abstract Light is considered the dominant environmental cue, or zeitgeber, influencing the sleep-wake cycle. Despite recognizing the importance of light for our well-being, less is known about the specific conditions under which light is optimally associated with better sleep. Therefore, a systematic review was conducted to examine the association between the amount and timing of light exposure in relation to sleep outcomes in healthy, community-dwelling adults. A systematic search was conducted of four databases from database inception to June 2016. In total, 45 studies met the review eligibility criteria with generally high study quality excepting for the specification of eligibility criteria and the justification of sample size. The majority of studies involved experimental manipulation of light (n = 32) vs observational designs (n = 13). Broad trends emerged suggesting that (1) bright light (>1000 lux) has positive implications for objectively assessed sleep outcomes compared to dim (<100 lux) and moderate light (100-1000 lux) and (2) bright light (>1000 lux) has positive implications for subjectively assessed sleep outcomes compared to moderate light (100-1000 lux). Effects due to the amount of light are moderated by the timing of light exposure such that, for objectively assessed sleep outcomes, brighter morning and evening light exposure are consistent with a shift in the timing of the sleep period to earlier and later in the day, respectively. For subjectively assessed sleep outcomes, brighter light delivered in the morning was associated with self-reported sleep improvements and brighter evening light exposure was associated with worse self-reported sleep.  
  Address Psychology Department, Virginia Commonwealth University, 800 W Franklin St, Room 203, PO Box 842018, Richmond, VA 23284-2018 USA; ndautovich(at)vcu.edu  
  Corporate Author Thesis  
  Publisher National Sleep Foundation Place of Publication Editor  
  Language English Summary Language (up) English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2352-7218 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2050  
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Author Obayashi, K.; Yamagami, Y.; Kurumatani, N.; Saeki, K. url  doi
openurl 
  Title Bedroom lighting environment and incident diabetes mellitus: a longitudinal study of the HEIJO-KYO cohort Type Journal Article
  Year 2019 Publication Sleep Medicine Abbreviated Journal Sleep Medicine  
  Volume 65 Issue Pages 1-3  
  Keywords Human Health; Metabolic disorders; diabetes; geriatrics  
  Abstract Objectives

Light information received by the brain influences human circadian timing and metabolism; low-level light at night (LAN) significantly increased body mass and led to prediabetes in mice. We hypothesized that LAN exposure increases the diabetes risk in humans. The aim of the present study was to evaluate a longitudinal association between LAN exposure and the incidence of diabetes in a general population.

Methods

In our prospective cohort study, bedroom light intensity was measured at 1-min intervals in 678 elderly participants without diabetes at baseline. The average light intensity recorded between bedtimes and rise times over two consecutive nights was used in the analysis.

Results

During follow-up (median, 42 months), 19 of the 678 participants (mean age, 70.6 years) developed diabetes. Poisson regression models revealed that the incidence rate for diabetes was significantly higher in the LAN group (average ≥5 lux, N = 128) than the dark group (average <5 lux, N = 550) (incidence rate ratio, 3.74; 95% confidence interval (CI), 1.55–9.05; p=0.003). Further propensity score adjustments in relation to LAN produced consistent results (incidence rate ratio, 3.19; 95% CI, 1.38–7.35; p=0.007). When the cut-off value of LAN was decreased to 3 lux, the relationship remained significant (incidence rate ratio 2.74; 95% CI, 1.19–6.33; p=0.018).

Conclusions

Our findings suggest that LAN exposure increases the incidence of diabetes in a general elderly population. Further research involving a large cohort with new-onset diabetes is warranted to elucidate these findings.
 
  Address Department of Epidemiology, Nara Medical University School of Medicine, 840 Shijocho, Kashiharashi, Nara, 634-8521, Japan; obayashi(at)naramed-u.ac.jp  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language English Summary Language (up) English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1389-9457 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2605  
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