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Author Panagiotou, M.; Rohling, J.H.T.; Deboer, T. url  doi
openurl 
  Title Sleep Network Deterioration as a Function of Dim-Light-At-Night Exposure Duration in a Mouse Model Type Journal Article
  Year 2020 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 2 Issue 3 Pages 308-324  
  Keywords Animals  
  Abstract Artificial light, despite its widespread and valuable use, has been associated withdeterioration of health and well-being, including altered circadian timing and sleep disturbances,particularly in nocturnal exposure. Recent findings from our lab reveal significant sleep andsleep electroencephalogram (EEG) changes owing to three months exposure to dim-light-at-night(DLAN). Aiming to further explore the detrimental effects of DLAN exposure, in the present study,we continuously recorded sleep EEG and the electromyogram for baseline 24-h and following 6-h sleepdeprivation in a varied DLAN duration scheme. C57BL/6J mice were exposed to a 12:12 h light:DLANcycle (75lux:5lux) vs. a 12:12 h light:dark cycle (75lux:0lux) for one day, one week, and one month.Our results show that sleep was already affected by a mere day of DLAN exposure with additionalcomplications emerging with increasing DLAN exposure duration, such as the gradual delay ofthe daily 24-h vigilance state rhythms. We conducted detrended fluctuation analysis (DFA) on thelocomotor activity data following 1-month and 3-month DLAN exposure, and a significantly lesshealthy rest-activity pattern, based on the decreased alpha values, was found in both conditionscompared to the control light-dark. Taking into account the behavioral, sleep and the sleep EEGparameters, our data suggest that DLAN exposure, even in the shortest duration, induces deleteriouseffects; nevertheless, potential compensatory mechanisms render the organism partly adjustable andable to cope. We think that, for this reason, our data do not always depict linear divergence amonggroups, as compared with control conditions. Chronic DLAN exposure impacts the sleep regulatorysystem, but also brain integrity, diminishing its adaptability and reactivity, especially apparent in thesleep EEG alterations and particular low alpha values following DFA.  
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  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 3078  
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Author Aarts, M.P.J.; Hartmeyer, S.L.; Morsink, K.; Kort, H.S.M.; de Kort, Y.A.W. url  doi
openurl 
  Title Can Special Light Glasses Reduce Sleepiness and Improve Sleep of Nightshift Workers? A Placebo-Controlled Explorative Field Study Type Journal Article
  Year 2020 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 2 Issue 2 Pages 225-245  
  Keywords Human Health  
  Abstract Nightshift workers go against the natural sleep–wake rhythm. Light can shift the circadian clock but can also induce acute alertness. This placebo-controlled exploratory field study examined the effectiveness of light glasses to improve alertness while reducing the sleep complaints of hospital nurses working nightshifts. In a crossover within-subjects design, 23 nurses participated, using treatment glasses and placebo glasses. Sleepiness and sleep parameters were measured. A linear mixed model analysis on sleepiness revealed no significant main effect of the light intervention. An interaction effect was found indicating that under the placebo condition, sleepiness was significantly higher on the first nightshift than on the last night, while under the treatment condition, sleepiness remained stable across nightshift sessions. Sleepiness during the commute home also showed a significant interaction effect, demonstrating that after the first nightshift, driver sleepiness was higher for placebo than for treatment. Subjective sleep quality showed a negative main effect of treatment vs. placebo, particularly after the first nightshift. In retrospect, both types of light glasses were self-rated as effective. The use of light glasses during the nightshift may help to reduce driver sleepiness during the commute home, which is relevant, as all participants drove home by car or (motor) bike.  
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  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2977  
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Author Walbeek, T.J.; Harrison, E.M.; Soler, R.R.; Gorman, M.R. url  doi
openurl 
  Title Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules Type Journal Article
  Year 2019 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 1 Issue 3 Pages 394-413  
  Keywords Animals  
  Abstract The circadian system is generally considered to be incapable of adjusting to rapid changes in sleep/work demands. In shiftworkers this leads to chronic circadian disruption and sleep loss, which together predict underperformance at work and negative health consequences. Two distinct experimental protocols have been proposed to increase circadian flexibility in rodents using dim light at night: rhythm bifurcation and T-cycle (i.e., day length) entrainment. Successful translation of such protocols to human shiftworkers could facilitate alignment of internal time with external demands. To assess entrainment flexibility following bifurcation and exposure to T-cycles, mice in Study 1 were repeatedly phase-shifted. Mice from experimental conditions rapidly phase-shifted their activity, while control mice showed expected transient misalignment. In Study 2 and 3, mice followed a several weeks-long intervention designed to model a modified DuPont or Continental shiftwork schedule, respectively. For both schedules, bifurcation and nocturnal dim lighting reduced circadian misalignment. Together, these studies demonstrate proof of concept that mammalian circadian systems can be rendered sufficiently flexible to adapt to multiple, rapidly changing shiftwork schedules. Flexible adaptation to exotic light-dark cycles likely relies on entrainment mechanisms that are distinct from traditional entrainment.  
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  Series Editor Series Title Abbreviated Series Title  
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  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2661  
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Author Prayag, A.; Münch, M.; Aeschbach, D.; Chellappa, S.; Gronfier, C. url  doi
openurl 
  Title Light Modulation of Human Clocks, Wake, and Sleep Type Journal Article
  Year 2019 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 1 Issue 1 Pages 193-208  
  Keywords Human Health; Review  
  Abstract Light, through its non-imaging forming effects, plays a dominant role on a myriad of physiological functions, including the human sleep–wake cycle. The non-image forming effects of light heavily rely on specific properties such as intensity, duration, timing, pattern, and wavelengths. Here, we address how specific properties of light influence sleep and wakefulness in humans through acute effects, e.g., on alertness, and/or effects on the circadian timing system. Of critical relevance, we discuss how different characteristics of light exposure across the 24-h day can lead to changes in sleep–wake timing, sleep propensity, sleep architecture, and sleep and wake electroencephalogram (EEG) power spectra. Ultimately, knowledge on how light affects sleep and wakefulness can improve light settings at home and at the workplace to improve health and well-being and optimize treatments of chronobiological disorders.  
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  Series Editor Series Title Abbreviated Series Title  
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  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2266  
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Author Choi, S. J., Park, H. R. & Joo, E. Y. url  doi
openurl 
  Title Effects of Light on Daytime Sleep in 12 Hours Night Shift Workers: A Field Study Type Journal Article
  Year 2019 Publication Korean Sleep Research Society Abbreviated Journal  
  Volume 16 Issue 1 Pages 26-35  
  Keywords Human Health; Sleep  
  Abstract Objectives: Night shift workers suffer from sleep and daytime disturbances due to circadian misalignment. To investigate the role of environmental light in daytime sleep following 12 h-night shift work. Methods: we enrolled 12 h-shift female nurses working at one university-affiliated hospital (n=10, mean age 26.6 years, shift work duration 3.8 years). This is a cross-over study to compare sleep between under light exposure (30 lux) and in the dark (<5 lux) following 12 h-night duty. Two sessions of experiments were underwent and the interval between sessions was about a month. Psychomotor vigilance test (PVT) had performed on awakening from sleep at each session and sleep-wake pattern had been monitored by actigraphy throughout the study period. Daytime sleep was also compared with night sleep of age-and gender matched daytime workers (n=10). Results: Sleep parameters and PVT scores were not different between two light conditions. Activities during sleep seemed to be more abundant under 30 lux condition than in the dark, which was not significant. Compared to night sleep, daytime sleep of shift workers was different in terms of rapid eye movement (REM) sleep. Three shift workers showed sleep onset REM sleep and first REM sleep period was the longest during daytime sleep. Conclusions: Unexpectedly, daytime sleep of 12 h night shift workers was well-maintained regardless of light exposure. Early occurrence of REM sleep and shorter sleep latency during daytime sleep suggest that shift workers meet with misalignment of circadian rhythm as well as increased homeostatic sleep pressure drive.  
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  Language Korean Summary Language Original Title  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ intern @ Serial 2635  
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