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Author Lowden, A.; Lemos, N.; Gonçalves, B.; Öztürk, G.; Louzada, F.; Pedrazzoli, M.; Moreno, C. url  doi
openurl 
  Title Delayed Sleep in Winter Related to Natural Daylight Exposure among Arctic Day Workers Type Journal Article
  Year 2018 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 1 Issue 1 Pages 105-116  
  Keywords Human Health  
  Abstract Natural daylight exposures in arctic regions vary substantially across seasons. Negative consequences have been observed in self-reports of sleep and daytime functions during the winter but have rarely been studied in detail. The focus of the present study set out to investigate sleep seasonality among indoor workers using objective and subjective measures. Sleep seasonality among daytime office workers (n = 32) in Kiruna (Sweden, 67.86° N, 20.23° E) was studied by comparing the same group of workers in a winter and summer week, including work and days off at the weekend, using actigraphs (motion loggers) and subjective ratings of alertness and mood. Actigraph analyses showed delayed sleep onset of 39 min in winter compared to the corresponding summer week (p < 0.0001) and shorter weekly sleep duration by 12 min (p = 0.0154). A delay of mid-sleep was present in winter at workdays (25 min, p < 0.0001) and more strongly delayed during days off (46 min, p < 0.0001). Sleepiness levels were higher in winter compared to summer (p < 0.05). Increased morning light exposure was associated with earlier mid-sleep (p < 0.001), while increased evening light exposure was associated with delay (p < 0.01). This study confirms earlier work that suggests that lack of natural daylight delays the sleep/wake cycle in a group of indoor workers, despite having access to electric lighting. Photic stimuli resulted in a general advanced sleep/wake rhythm during summer and increased alertness levels.  
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  ISSN 2624-5175 ISBN Medium  
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  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2137  
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Author Wang, H.-B.; Whittaker, D.S.; Truong, D.; Mulji, A.K.; Ghiani, C.A.; Loh, D.H.; Colwell, C.S. url  doi
openurl 
  Title Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease Type Journal Article
  Year 2017 Publication Neurobiology of Sleep and Circadian Rhythms Abbreviated Journal Neurobiology of Sleep and Circadian Rhythms  
  Volume 2 Issue Pages 39-52  
  Keywords animals; Human Health  
  Abstract Patients with Huntington's disease (HD) exhibit movement disorders, psychiatric disturbance and cognitive impairments as the disease progresses. Abnormal sleep/wake cycles are common among HD patients with reports of delayed sleep onset, fatigue during the day, and a delayed pattern of melatonin secretion all of which suggest circadian dysfunction. Mouse models of HD confirm disrupted circadian rhythms with pathophysiology found in the central circadian clock (suprachiasmatic nucleus). Importantly, circadian dysfunction manifests early in disease, even before the classic motor symptoms, in both patients and mouse models. Therefore, we hypothesize that the circadian dysfunction may interact with the disease pathology and exacerbate the HD symptoms. If correct, early intervention may benefit patients and delay disease progression. One test of this hypothesis is to determine whether light therapy designed to strengthen this intrinsic timing system can delay the disease progression in mouse models. Therefore, we determined the impact of blue wavelength-enriched light on two HD models: the BACHD and Q175 mice. Both models received 6 hours of blue-light at the beginning of their daily light cycle for 3 months. After treatment, both genotypes showed improvements in their locomotor activity rhythm without significant change to their sleep behavior. Critically, treated mice of both lines exhibited improved motor performance compared to untreated controls. Focusing on the Q175 genotype, we sought to determine whether the treatment altered signaling pathways in brain regions known to be impacted by HD using NanoString gene expression assays. We found that the expression of several HD relevant markers was altered in the striatum and cortex of the treated mice. Our study demonstrates that strengthening the circadian system can delay the progression of HD in pre-clinical models. This work suggests that lighting conditions should be considered when managing treatment of HD and other neurodegenerative disorders.  
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  ISSN 2451-9944 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1626  
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Author Crowley, S.J.; Suh, C.; Molina, T.A.; Fogg, L.F.; Sharkey, K.M.; Carskadon, M.A. url  doi
openurl 
  Title Estimating the dim light melatonin onset of adolescents within a 6-h sampling window: the impact of sampling rate and threshold method Type Journal Article
  Year 2015 Publication Sleep Medicine Abbreviated Journal Sleep Medicine  
  Volume 20 Issue Pages 59-66  
  Keywords Human Health  
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  Series Volume Series Issue Edition  
  ISSN 1389-9457 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1324  
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Author Paul, M.A.; Love, R.J.; Hawton, A.; Brett, K.; McCreary, D.R.; Arendt, J. url  doi
openurl 
  Title Sleep deficits in the high Arctic summer in relation to light exposure and behaviour: use of melatonin as a countermeasure Type Journal Article
  Year 2015 Publication Sleep Medicine Abbreviated Journal Sleep Medicine  
  Volume Issue Pages  
  Keywords Human Health; Sleep  
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  ISSN 1389-9457 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1093  
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Author Kim, J.; Hwang, K.; Cho, J.; Koo, D.; Joo, E.; Hong, S. url  doi
openurl 
  Title Effect of bedside light on sleep quality and background eeg rhythms Type Journal Article
  Year 2013 Publication Sleep Medicine Abbreviated Journal Sleep Medicine  
  Volume 14 Issue Pages e170  
  Keywords Human Health  
  Abstract Artificial lighting has benefited society by extending the length of a productive day, but it can be ”light pollution” when it becomes excessive. Unnecessary exposure to artificial light at night can cause myopia, obesity, metabolic disorders and even some type of cancers.  
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  ISSN 1389-9457 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 502  
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