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Author (up) He, C.; Anand, S.T.; Ebell, M.H.; Vena, J.E.; Robb, S.W. url  doi
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  Title Circadian disrupting exposures and breast cancer risk: a meta-analysis Type Journal Article
  Year 2014 Publication International Archives of Occupational and Environmental Health Abbreviated Journal Int Arch Occup Environ Health  
  Volume 88 Issue 5 Pages 533-547  
  Keywords Human Health; Circadian disruption; Breast cancer; Meta-analysis; Oncogenesis; BrCA; shift work; meta-analysis  
  Abstract PURPOSE: Shift work, short sleep duration, employment as a flight attendant, and exposure to light at night, all potential causes of circadian disruption, have been inconsistently associated with breast cancer (BrCA) risk. The aim of this meta-analysis is to quantitatively evaluate the combined and independent effects of exposure to different sources of circadian disruption on BrCA risk in women. METHODS: Relevant studies published through January 2014 were identified by searching the PubMed database. The pooled relative risks (RRs) and corresponding 95 % confidence intervals (CIs) were estimated using fixed- or random effects models as indicated by heterogeneity tests. Generalized least squares trend test was used to assess dose-response relationships. RESULTS: A total of 28 studies, 15 on shift work, 7 on short sleep duration, 3 on flight attendants, and 6 on light at night were included in the analysis. The combined analysis suggested a significantly positive association between circadian disruption and BrCA risk (RR = 1.14; 95 % CI 1.08-1.21). Separate analyses showed that the RR for BrCA was 1.19 (95 % CI 1.08-1.32) for shift work, 1.120 (95 % CI 1.119-1.121) for exposure to light at night, 1.56 (95 % CI 1.10-2.21) for employment as a flight attendant, and 0.96 (95 % CI 0.86-1.06) for short sleep duration. A dose-response analysis showed that each 10-year increment of shift work was associated with 16 % higher risk of BrCA (95 % CI 1.06-1.27) based on selected case-control studies. No significant dose-response effects of exposure to light at night and sleep deficiency were found on BrCA risk. CONCLUSIONS: Our meta-analysis demonstrates that circadian disruption is associated with an increased BrCA risk in women. This association varied by specific sources of circadian disrupting exposures, and a dose-response relationship remains uncertain. Therefore, future rigorous prospective studies are needed to confirm these relationships.  
  Address Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 101 Buck Road, Health Sciences Campus, B.S. Miller Hall, Athens, GA, 30602, USA, willahe@uga.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0340-0131 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25261318 Approved no  
  Call Number IDA @ john @ Serial 1064  
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