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Author Fernandez, F.; Lu, D.; Ha, P.; Costacurta, P.; Chavez, R.; Heller, H.C.; Ruby, N.F.
Title Circadian rhythm. Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing Type Journal Article
Year 2014 Publication Science (New York, N.Y.) Abbreviated Journal Science
Volume 346 Issue 6211 Pages 854-857
Keywords Animals; circadian rhythm; circadian disruption; memory; suprachiasmatic nucleus; Biological Clocks; dysrhythmia; Siberian hamster; Phodopus sungorus; sleep
Abstract (up) Chronic circadian dysfunction impairs declarative memory in humans but has little effect in common rodent models of arrhythmia caused by clock gene knockouts or surgical ablation of the suprachiasmatic nucleus (SCN). An important problem overlooked in these translational models is that human dysrhythmia occurs while SCN circuitry is genetically and neurologically intact. Siberian hamsters (Phodopus sungorus) are particularly well suited for translational studies because they can be made arrhythmic by a one-time photic treatment that severely impairs spatial and recognition memory. We found that once animals are made arrhythmic, subsequent SCN ablation completely rescues memory processing. These data suggest that the inhibitory effects of a malfunctioning SCN on cognition require preservation of circuitry between the SCN and downstream targets that are lost when these connections are severed.
Address Biology Department, Stanford University, Stanford CA, USA. ruby@stanford.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0036-8075 ISBN Medium
Area Expedition Conference
Notes PMID:25395537 Approved no
Call Number IDA @ john @ Serial 1069
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